BRD-A45498368_WYE-125132_HA1E_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

180 genes differentially expressed following the BRD-A45498368_WYE-125132_HA1E_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ADCY1 adenylate cyclase 1 (brain)
ADGRG6 adhesion G protein-coupled receptor G6
ADIRF adipogenesis regulatory factor
AHNAK2 AHNAK nucleoprotein 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ATP9A ATPase, class II, type 9A
C2CD5 C2 calcium-dependent domain containing 5
C6ORF48 chromosome 6 open reading frame 48
CALML5 calmodulin-like 5
CAMLG calcium modulating ligand
CD44 CD44 molecule (Indian blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEP57 centrosomal protein 57kDa
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CIRBP cold inducible RNA binding protein
CRTC3 CREB regulated transcription coactivator 3
CXADR coxsackie virus and adenovirus receptor
DCLK1 doublecortin-like kinase 1
DHRS3 dehydrogenase/reductase (SDR family) member 3
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF3F eukaryotic translation initiation factor 3, subunit F
ETHE1 ethylmalonic encephalopathy 1
FAR2 fatty acyl CoA reductase 2
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
GAA glucosidase, alpha; acid
GALC galactosylceramidase
GLTSCR2 glioma tumor suppressor candidate region gene 2
GPM6B glycoprotein M6B
GPX4 glutathione peroxidase 4
GRIA2 glutamate receptor, ionotropic, AMPA 2
HES1 hes family bHLH transcription factor 1
HIST3H2A histone cluster 3, H2a
HMGA1 high mobility group AT-hook 1
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
INSM1 insulinoma-associated 1
IRS2 insulin receptor substrate 2
ITGA6 integrin, alpha 6
ITGB4 integrin, beta 4
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
LETMD1 LETM1 domain containing 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MMP3 matrix metallopeptidase 3
NPEPL1 aminopeptidase-like 1
OSBPL1A oxysterol binding protein-like 1A
PARP6 poly (ADP-ribose) polymerase family, member 6
PCSK1 proprotein convertase subtilisin/kexin type 1
PGLS 6-phosphogluconolactonase
PLCB4 phospholipase C, beta 4
POSTN periostin, osteoblast specific factor
PPAP2C phosphatidic acid phosphatase type 2C
PTEN phosphatase and tensin homolog
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SPRY2 sprouty homolog 2 (Drosophila)
SSFA2 sperm specific antigen 2
SULF1 sulfatase 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
SYNE2 spectrin repeat containing, nuclear envelope 2
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TMSB15A thymosin beta 15a
TRIP6 thyroid hormone receptor interactor 6
WDR19 WD repeat domain 19

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ADGRG1 adhesion G protein-coupled receptor G1
ADI1 acireductone dioxygenase 1
AK4 adenylate kinase 4
ALDOC aldolase C, fructose-bisphosphate
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
ANXA6 annexin A6
ARF4 ADP-ribosylation factor 4
ASNS asparagine synthetase (glutamine-hydrolyzing)
AURKA aurora kinase A
BAMBI BMP and activin membrane-bound inhibitor
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BST2 bone marrow stromal cell antigen 2
C7 complement component 7
CA12 carbonic anhydrase XII
CAB39 calcium binding protein 39
CCL2 chemokine (C-C motif) ligand 2
CD24 CD24 molecule
CFI complement factor I
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
COL5A1 collagen, type V, alpha 1
CRELD2 cysteine-rich with EGF-like domains 2
CTSC cathepsin C
CYB5A cytochrome b5 type A (microsomal)
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EMP3 epithelial membrane protein 3
ENO1 enolase 1, (alpha)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAM162A family with sequence similarity 162, member A
FASTKD5 FAST kinase domains 5
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FKBP11 FK506 binding protein 11, 19 kDa
FKBP14 FK506 binding protein 14, 22 kDa
GBE1 glucan (1,4-alpha-), branching enzyme 1
GCLM glutamate-cysteine ligase, modifier subunit
GPX3 glutathione peroxidase 3
GSTM3 glutathione S-transferase mu 3 (brain)
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPB8 heat shock 22kDa protein 8
HYOU1 hypoxia up-regulated 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
INSIG1 insulin induced gene 1
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JCHAIN joining chain of multimeric IgA and IgM
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
LDLR low density lipoprotein receptor
LRRC59 leucine rich repeat containing 59
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAL mal, T-cell differentiation protein
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MIR22HG MIR22 host gene
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MSMO1 methylsterol monooxygenase 1
MT1E metallothionein 1E
MT1X metallothionein 1X
MYCBP MYC binding protein
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NQO1 NAD(P)H dehydrogenase, quinone 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDIA6 protein disulfide isomerase family A, member 6
PFN2 profilin 2
PGK1 phosphoglycerate kinase 1
PHGDH phosphoglycerate dehydrogenase
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSPH phosphoserine phosphatase
PTGDS prostaglandin D2 synthase 21kDa (brain)
PYCR1 pyrroline-5-carboxylate reductase 1
QPRT quinolinate phosphoribosyltransferase
RGS2 regulator of G-protein signaling 2
S100A10 S100 calcium binding protein A10
S100A8 S100 calcium binding protein A8
SC5D sterol-C5-desaturase
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC1 syndecan 1
SEC24D SEC24 family member D
SELT selenoprotein T
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLPI secretory leukocyte peptidase inhibitor
SNX11 sorting nexin 11
SQLE squalene epoxidase
SRPRB signal recognition particle receptor, B subunit
SUSD4 sushi domain containing 4
TCL1A T-cell leukemia/lymphoma 1A
THBS1 thrombospondin 1
TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast)
TMED9 transmembrane emp24 protein transport domain containing 9
TNNT1 troponin T type 1 (skeletal, slow)
TSPAN13 tetraspanin 13
VDAC1 voltage-dependent anion channel 1
VLDLR very low density lipoprotein receptor
WT1 Wilms tumor 1
XBP1 X-box binding protein 1