BRD-A45498368_WYE-125132_HA1E_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

291 genes differentially expressed following the BRD-A45498368_WYE-125132_HA1E_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABHD11 abhydrolase domain containing 11
ADAM28 ADAM metallopeptidase domain 28
AHNAK2 AHNAK nucleoprotein 2
AMDHD2 amidohydrolase domain containing 2
ANGPTL2 angiopoietin-like 2
ANKRD36B ankyrin repeat domain 36B
ANXA1 annexin A1
ANXA4 annexin A4
ARG1 arginase 1
ARL4C ADP-ribosylation factor-like 4C
ATP9A ATPase, class II, type 9A
C6ORF48 chromosome 6 open reading frame 48
CAMLG calcium modulating ligand
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK19 cyclin-dependent kinase 19
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEP57 centrosomal protein 57kDa
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHMP6 charged multivesicular body protein 6
CIRBP cold inducible RNA binding protein
CLEC2B C-type lectin domain family 2, member B
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSNK1D casein kinase 1, delta
CSNK2A2 casein kinase 2, alpha prime polypeptide
CTSD cathepsin D
CTSK cathepsin K
CUTA cutA divalent cation tolerance homolog (E. coli)
CYBRD1 cytochrome b reductase 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP6 dual specificity phosphatase 6
EIF3E eukaryotic translation initiation factor 3, subunit E
EIF3F eukaryotic translation initiation factor 3, subunit F
EIF3L eukaryotic translation initiation factor 3, subunit L
EIF4B eukaryotic translation initiation factor 4B
ENOSF1 enolase superfamily member 1
ETV1 ets variant 1
EVI2A ecotropic viral integration site 2A
EXOC1 exocyst complex component 1
FBXO21 F-box protein 21
FXR1 fragile X mental retardation, autosomal homolog 1
GATAD1 GATA zinc finger domain containing 1
GLRX glutaredoxin (thioltransferase)
GLTSCR2 glioma tumor suppressor candidate region gene 2
GNB5 guanine nucleotide binding protein (G protein), beta 5
GNPDA1 glucosamine-6-phosphate deaminase 1
GPR137B G protein-coupled receptor 137B
GPX4 glutathione peroxidase 4
GSDMB gasdermin B
GUSB glucuronidase, beta
HEBP2 heme binding protein 2
HIST3H2A histone cluster 3, H2a
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
HOXA5 homeobox A5
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
IGBP1 immunoglobulin (CD79A) binding protein 1
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
INSR insulin receptor
IPO7 importin 7
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITGB4 integrin, beta 4
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KLHDC2 kelch domain containing 2
KYNU kynureninase
LETMD1 LETM1 domain containing 1
LINC00342 long intergenic non-protein coding RNA 342
LXN latexin
MAP2K5 mitogen-activated protein kinase kinase 5
MET MET proto-oncogene, receptor tyrosine kinase
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
MLPH melanophilin
N4BP2L1 NEDD4 binding protein 2-like 1
N4BP2L2 NEDD4 binding protein 2-like 2
NELL2 NEL-like 2 (chicken)
NPC1 Niemann-Pick disease, type C1
NSUN5P2 NOP2/Sun domain family, member 5 pseudogene 2
NT5E 5'-nucleotidase, ecto (CD73)
OPHN1 oligophrenin 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PARP6 poly (ADP-ribose) polymerase family, member 6
PGLS 6-phosphogluconolactonase
PHYH phytanoyl-CoA 2-hydroxylase
POSTN periostin, osteoblast specific factor
PPAP2C phosphatidic acid phosphatase type 2C
PTPRO protein tyrosine phosphatase, receptor type, O
PXMP2 peroxisomal membrane protein 2, 22kDa
QARS glutaminyl-tRNA synthetase
RAB4A RAB4A, member RAS oncogene family
RAD50 RAD50 homolog (S. cerevisiae)
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RGS17 regulator of G-protein signaling 17
SCD5 stearoyl-CoA desaturase 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC35E2B solute carrier family 35, member E2B
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOX11 SRY (sex determining region Y)-box 11
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
STX1A syntaxin 1A (brain)
SYNE2 spectrin repeat containing, nuclear envelope 2
TCEA2 transcription elongation factor A (SII), 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TM4SF4 transmembrane 4 L six family member 4
TPP1 tripeptidyl peptidase I
VAT1 vesicle amine transport 1
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae)
WDR13 WD repeat domain 13
WDR19 WD repeat domain 19
WDR45 WD repeat domain 45
WWOX WW domain containing oxidoreductase
XIST X inactive specific transcript (non-protein coding)
YBX3 Y box binding protein 3

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ACAT2 acetyl-CoA acetyltransferase 2
ACKR3 atypical chemokine receptor 3
ACTB actin, beta
ADAM19 ADAM metallopeptidase domain 19
ADGRG1 adhesion G protein-coupled receptor G1
AK4 adenylate kinase 4
ALB albumin
ALDOC aldolase C, fructose-bisphosphate
ALOX15B arachidonate 15-lipoxygenase, type B
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
AQP3 aquaporin 3 (Gill blood group)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
BAMBI BMP and activin membrane-bound inhibitor
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BIRC3 baculoviral IAP repeat containing 3
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C1ORF116 chromosome 1 open reading frame 116
CALB1 calbindin 1, 28kDa
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CD58 CD58 molecule
CDC20 cell division cycle 20
CDC42 cell division cycle 42
CFLAR CASP8 and FADD-like apoptosis regulator
CNN3 calponin 3, acidic
COL4A5 collagen, type IV, alpha 5
CRYAB crystallin, alpha B
CSRP2 cysteine and glycine-rich protein 2
CTSC cathepsin C
CTSZ cathepsin Z
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL12 chemokine (C-X-C motif) ligand 12
CYB5A cytochrome b5 type A (microsomal)
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
EDN1 endothelin 1
EFHD1 EF-hand domain family, member D1
EGF epidermal growth factor
EGLN3 egl-9 family hypoxia-inducible factor 3
EMP2 epithelial membrane protein 2
FADS2 fatty acid desaturase 2
FADS3 fatty acid desaturase 3
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FERMT2 fermitin family member 2
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FILIP1L filamin A interacting protein 1-like
FOLR1 folate receptor 1 (adult)
GATA6 GATA binding protein 6
GATAD2A GATA zinc finger domain containing 2A
GBP1 guanylate binding protein 1, interferon-inducible
GCLM glutamate-cysteine ligase, modifier subunit
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GLIPR1 GLI pathogenesis-related 1
GPC1 glypican 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
GSTA1 glutathione S-transferase alpha 1
GSTM3 glutathione S-transferase mu 3 (brain)
H2BFS H2B histone family, member S (pseudogene)
HILPDA hypoxia inducible lipid droplet-associated
HIST1H2BD histone cluster 1, H2bd
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOMER2 homer scaffolding protein 2
HOXC10 homeobox C10
HSPA4L heat shock 70kDa protein 4-like
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
HYOU1 hypoxia up-regulated 1
ICAM1 intercellular adhesion molecule 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
IGSF3 immunoglobulin superfamily, member 3
IL32 interleukin 32
IL6ST interleukin 6 signal transducer
IL7R interleukin 7 receptor
INSIG1 insulin induced gene 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JCHAIN joining chain of multimeric IgA and IgM
JMJD6 jumonji domain containing 6
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAL mal, T-cell differentiation protein
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSMO1 methylsterol monooxygenase 1
MSX1 msh homeobox 1
MT1E metallothionein 1E
MYCBP MYC binding protein
MYL9 myosin, light chain 9, regulatory
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NDRG1 N-myc downstream regulated 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEFH neurofilament, heavy polypeptide
NEFL neurofilament, light polypeptide
NES nestin
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPR3 natriuretic peptide receptor 3
P3H2 prolyl 3-hydroxylase 2
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PALLD palladin, cytoskeletal associated protein
PBK PDZ binding kinase
PEA15 phosphoprotein enriched in astrocytes 15
PEG10 paternally expressed 10
PELI1 pellino E3 ubiquitin protein ligase 1
PGAM1 phosphoglycerate mutase 1 (brain)
PGK1 phosphoglycerate kinase 1
PIR pirin (iron-binding nuclear protein)
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PON2 paraoxonase 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRAME preferentially expressed antigen in melanoma
PRKCB protein kinase C, beta
PRSS23 protease, serine, 23
PTGDS prostaglandin D2 synthase 21kDa (brain)
QPRT quinolinate phosphoribosyltransferase
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RHCG Rh family, C glycoprotein
RHOB ras homolog family member B
RIT1 Ras-like without CAAX 1
RSU1 Ras suppressor protein 1
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC2 syndecan 2
SELT selenoprotein T
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SIAH2 siah E3 ubiquitin protein ligase 2
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SPAG4 sperm associated antigen 4
SQLE squalene epoxidase
SRGN serglycin
STK17A serine/threonine kinase 17a
TACSTD2 tumor-associated calcium signal transducer 2
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
THBS1 thrombospondin 1
TMEM47 transmembrane protein 47
TNC tenascin C
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TPM1 tropomyosin 1 (alpha)
TTC39A tetratricopeptide repeat domain 39A
TUBA4A tubulin, alpha 4a
TWF1 twinfilin actin binding protein 1
VCAM1 vascular cell adhesion molecule 1
WNT5A wingless-type MMTV integration site family, member 5A