BRD-A45498368_WYE-125132_HA1E_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

251 genes differentially expressed following the BRD-A45498368_WYE-125132_HA1E_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ADRB2 adrenoceptor beta 2, surface
AHCY adenosylhomocysteinase
AHNAK2 AHNAK nucleoprotein 2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMDHD2 amidohydrolase domain containing 2
ANKRD36B ankyrin repeat domain 36B
APLP2 amyloid beta (A4) precursor-like protein 2
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
C6ORF48 chromosome 6 open reading frame 48
CAMLG calcium modulating ligand
CCDC85B coiled-coil domain containing 85B
CCDC93 coiled-coil domain containing 93
CCL5 chemokine (C-C motif) ligand 5
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCND1 cyclin D1
CD44 CD44 molecule (Indian blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEP57 centrosomal protein 57kDa
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CIRBP cold inducible RNA binding protein
COL2A1 collagen, type II, alpha 1
CSNK2A2 casein kinase 2, alpha prime polypeptide
CTSK cathepsin K
CXADR coxsackie virus and adenovirus receptor
CYBRD1 cytochrome b reductase 1
DALRD3 DALR anticodon binding domain containing 3
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLG5 discs, large homolog 5 (Drosophila)
DSP desmoplakin
DUSP6 dual specificity phosphatase 6
EDN1 endothelin 1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF3D eukaryotic translation initiation factor 3, subunit D
EIF3F eukaryotic translation initiation factor 3, subunit F
EIF3G eukaryotic translation initiation factor 3, subunit G
EIF3H eukaryotic translation initiation factor 3, subunit H
EIF3K eukaryotic translation initiation factor 3, subunit K
EIF4B eukaryotic translation initiation factor 4B
EIF5A eukaryotic translation initiation factor 5A
ETHE1 ethylmalonic encephalopathy 1
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit
FCGBP Fc fragment of IgG binding protein
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FXR1 fragile X mental retardation, autosomal homolog 1
GLTSCR2 glioma tumor suppressor candidate region gene 2
GOLGA8A golgin A8 family, member A
GPNMB glycoprotein (transmembrane) nmb
GPX4 glutathione peroxidase 4
HDAC6 histone deacetylase 6
HEBP1 heme binding protein 1
HES1 hes family bHLH transcription factor 1
HMGA1 high mobility group AT-hook 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
IGBP1 immunoglobulin (CD79A) binding protein 1
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JADE2 jade family PHD finger 2
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KRT20 keratin 20, type I
LETMD1 LETM1 domain containing 1
LOC399491
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
MMP9 matrix metallopeptidase 9
MTA1 metastasis associated 1
MUTYH mutY homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
MZT2A mitotic spindle organizing protein 2A
NAP1L1 nucleosome assembly protein 1-like 1
NELL2 NEL-like 2 (chicken)
NFIB nuclear factor I/B
NSA2 NSA2 ribosome biogenesis homolog (S. cerevisiae)
NSUN5 NOP2/Sun domain family, member 5
NSUN5P1 NOP2/Sun domain family, member 5 pseudogene 1
NSUN5P2 NOP2/Sun domain family, member 5 pseudogene 2
NT5E 5'-nucleotidase, ecto (CD73)
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OPTN optineurin
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form)
PGLS 6-phosphogluconolactonase
PHB2 prohibitin 2
PILRB paired immunoglobin-like type 2 receptor beta
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PLAU plasminogen activator, urokinase
PLXNA1 plexin A1
PRKCSH protein kinase C substrate 80K-H
PRKX protein kinase, X-linked
QARS glutaminyl-tRNA synthetase
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RPL36 ribosomal protein L36
RPS14P3 ribosomal protein S14 pseudogene 3
SET SET nuclear proto-oncogene
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SPATA20 spermatogenesis associated 20
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
SQSTM1 sequestosome 1
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
SULF1 sulfatase 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
SYNE2 spectrin repeat containing, nuclear envelope 2
TCEA2 transcription elongation factor A (SII), 2
TFPI2 tissue factor pathway inhibitor 2
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TM4SF1 transmembrane 4 L six family member 1
TMSB15A thymosin beta 15a
UBXN1 UBX domain protein 1
YPEL1 yippee-like 1 (Drosophila)
ZNF91 zinc finger protein 91
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ACAT2 acetyl-CoA acetyltransferase 2
ACKR3 atypical chemokine receptor 3
ACSL1 acyl-CoA synthetase long-chain family member 1
ADAM9 ADAM metallopeptidase domain 9
ADGRG1 adhesion G protein-coupled receptor G1
ADI1 acireductone dioxygenase 1
AK4 adenylate kinase 4
AKR1C3 aldo-keto reductase family 1, member C3
ALB albumin
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDOC aldolase C, fructose-bisphosphate
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
ANXA6 annexin A6
AQP3 aquaporin 3 (Gill blood group)
ARF4 ADP-ribosylation factor 4
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
AURKA aurora kinase A
BAG2 BCL2-associated athanogene 2
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C7 complement component 7
CCL2 chemokine (C-C motif) ligand 2
CD58 CD58 molecule
CLU clusterin
COL1A1 collagen, type I, alpha 1
COL5A1 collagen, type V, alpha 1
COMMD8 COMM domain containing 8
CRELD2 cysteine-rich with EGF-like domains 2
CTSC cathepsin C
CYB5A cytochrome b5 type A (microsomal)
CYCS cytochrome c, somatic
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
EGLN3 egl-9 family hypoxia-inducible factor 3
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ENO1 enolase 1, (alpha)
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FADS2 fatty acid desaturase 2
FAM98A family with sequence similarity 98, member A
FGG fibrinogen gamma chain
FKBP14 FK506 binding protein 14, 22 kDa
FOLR1 folate receptor 1 (adult)
GARS glycyl-tRNA synthetase
GBE1 glucan (1,4-alpha-), branching enzyme 1
GCLM glutamate-cysteine ligase, modifier subunit
GPC3 glypican 3
GSTA1 glutathione S-transferase alpha 1
GSTM3 glutathione S-transferase mu 3 (brain)
HILPDA hypoxia inducible lipid droplet-associated
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPB8 heat shock 22kDa protein 8
HYOU1 hypoxia up-regulated 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
INSIG1 insulin induced gene 1
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
LDLR low density lipoprotein receptor
LRRC17 leucine rich repeat containing 17
LRRC59 leucine rich repeat containing 59
LSM1 LSM1, U6 small nuclear RNA associated
MAGT1 magnesium transporter 1
MAL mal, T-cell differentiation protein
MARS methionyl-tRNA synthetase
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
METTL7A methyltransferase like 7A
MFAP4 microfibrillar-associated protein 4
MLEC malectin
MSMO1 methylsterol monooxygenase 1
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NAV3 neuron navigator 3
NME1 NME/NM23 nucleoside diphosphate kinase 1
NUPL1 nucleoporin like 1
OPN3 opsin 3
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCOLCE2 procollagen C-endopeptidase enhancer 2
PCP4 Purkinje cell protein 4
PDIA3 protein disulfide isomerase family A, member 3
PDIA6 protein disulfide isomerase family A, member 6
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PHGDH phosphoglycerate dehydrogenase
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PIR pirin (iron-binding nuclear protein)
PKM pyruvate kinase, muscle
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
PYCR1 pyrroline-5-carboxylate reductase 1
QPRT quinolinate phosphoribosyltransferase
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RBP1 retinol binding protein 1, cellular
RBX1 ring-box 1, E3 ubiquitin protein ligase
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RHOB ras homolog family member B
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPL37A ribosomal protein L37a
SC5D sterol-C5-desaturase
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC2 syndecan 2
SEC24D SEC24 family member D
SELT selenoprotein T
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SORD sorbitol dehydrogenase
SQLE squalene epoxidase
SRPRB signal recognition particle receptor, B subunit
SSR1 signal sequence receptor, alpha
TARS threonyl-tRNA synthetase
TBC1D4 TBC1 domain family, member 4
TFF3 trefoil factor 3 (intestinal)
TFRC transferrin receptor
TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast)
TNC tenascin C
TSPAN13 tetraspanin 13
TXNDC9 thioredoxin domain containing 9
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
XBP1 X-box binding protein 1
YARS tyrosyl-tRNA synthetase