BRD-A45498368_WYE-125132_HA1E_24_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

144 genes differentially expressed following the BRD-A45498368_WYE-125132_HA1E_24_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ANKRD36B ankyrin repeat domain 36B
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLCA1 chloride channel accessory 1
EDN1 endothelin 1
EFS embryonal Fyn-associated substrate
EIF3F eukaryotic translation initiation factor 3, subunit F
EIF4B eukaryotic translation initiation factor 4B
ELOVL2 ELOVL fatty acid elongase 2
ETHE1 ethylmalonic encephalopathy 1
FAR2 fatty acyl CoA reductase 2
FCN1 ficolin (collagen/fibrinogen domain containing) 1
GADD45B growth arrest and DNA-damage-inducible, beta
GLTSCR2 glioma tumor suppressor candidate region gene 2
GPX4 glutathione peroxidase 4
GSDMB gasdermin B
GSE1 Gse1 coiled-coil protein
HEBP1 heme binding protein 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
IFITM1 interferon induced transmembrane protein 1
IRS2 insulin receptor substrate 2
JADE2 jade family PHD finger 2
KCTD12 potassium channel tetramerization domain containing 12
KRT20 keratin 20, type I
LETMD1 LETM1 domain containing 1
LINC00342 long intergenic non-protein coding RNA 342
LOC100272216 uncharacterized LOC100272216
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
MGLL monoglyceride lipase
MYO6 myosin VI
N4BP2L2 NEDD4 binding protein 2-like 2
NELL2 NEL-like 2 (chicken)
NPEPL1 aminopeptidase-like 1
PDCD6 programmed cell death 6
POSTN periostin, osteoblast specific factor
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
SIRT3 sirtuin 3
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC35E2B solute carrier family 35, member E2B
SOX11 SRY (sex determining region Y)-box 11
STK10 serine/threonine kinase 10
SULF1 sulfatase 1
TFPI2 tissue factor pathway inhibitor 2
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TPP1 tripeptidyl peptidase I
TUBB2B tubulin, beta 2B class IIb
TXNIP thioredoxin interacting protein
VCAN versican
WDR19 WD repeat domain 19
ZBTB20 zinc finger and BTB domain containing 20
ZNF83 zinc finger protein 83
ZNF91 zinc finger protein 91
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ADGRG1 adhesion G protein-coupled receptor G1
ADI1 acireductone dioxygenase 1
AK4 adenylate kinase 4
ALDOC aldolase C, fructose-bisphosphate
AQP3 aquaporin 3 (Gill blood group)
ASF1A anti-silencing function 1A histone chaperone
BAG2 BCL2-associated athanogene 2
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C3 complement component 3
C7 complement component 7
CCDC47 coiled-coil domain containing 47
CCL2 chemokine (C-C motif) ligand 2
CD58 CD58 molecule
CLU clusterin
CP ceruloplasmin (ferroxidase)
CYB5A cytochrome b5 type A (microsomal)
CYCS cytochrome c, somatic
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
EIF5A eukaryotic translation initiation factor 5A
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FKBP14 FK506 binding protein 14, 22 kDa
FOLR1 folate receptor 1 (adult)
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GARS glycyl-tRNA synthetase
GCLM glutamate-cysteine ligase, modifier subunit
GPX3 glutathione peroxidase 3
HEXIM1 hexamethylene bis-acetamide inducible 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPB8 heat shock 22kDa protein 8
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IGFBP5 insulin-like growth factor binding protein 5
IL1R1 interleukin 1 receptor, type I
INSIG1 insulin induced gene 1
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KRT4 keratin 4, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LDLR low density lipoprotein receptor
LMO4 LIM domain only 4
LRRC59 leucine rich repeat containing 59
LY6D lymphocyte antigen 6 complex, locus D
MAGT1 magnesium transporter 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MANF mesencephalic astrocyte-derived neurotrophic factor
MSMO1 methylsterol monooxygenase 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDIA6 protein disulfide isomerase family A, member 6
PEG10 paternally expressed 10
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PHGDH phosphoglycerate dehydrogenase
PI3 peptidase inhibitor 3, skin-derived
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRDX1 peroxiredoxin 1
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
REXO2 RNA exonuclease 2
RPN2 ribophorin II
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC2 syndecan 2
SERINC5 serine incorporator 5
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLPI secretory leukocyte peptidase inhibitor
SORD sorbitol dehydrogenase
SQLE squalene epoxidase
SRPRB signal recognition particle receptor, B subunit
STC1 stanniocalcin 1
SUB1 SUB1 homolog (S. cerevisiae)
TARS threonyl-tRNA synthetase
TFRC transferrin receptor
TMEM100 transmembrane protein 100
TNC tenascin C
TRIM16 tripartite motif containing 16
TUBA4A tubulin, alpha 4a
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
UGDH UDP-glucose 6-dehydrogenase