BRD-A45498368_WYE-125132_BT20_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

180 genes differentially expressed following the BRD-A45498368_WYE-125132_BT20_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHNAK2 AHNAK nucleoprotein 2
ANG angiogenin, ribonuclease, RNase A family, 5
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
ARG1 arginase 1
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BCL2A1 BCL2-related protein A1
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
C1ORF115 chromosome 1 open reading frame 115
CD46 CD46 molecule, complement regulatory protein
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK19 cyclin-dependent kinase 19
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFLAR CASP8 and FADD-like apoptosis regulator
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLU clusterin
CTGF connective tissue growth factor
CTSB cathepsin B
CXCL3 chemokine (C-X-C motif) ligand 3
CYTH1 cytohesin 1
DDAH2 dimethylarginine dimethylaminohydrolase 2
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DSP desmoplakin
DUSP5 dual specificity phosphatase 5
EFNA1 ephrin-A1
ERBB3 erb-b2 receptor tyrosine kinase 3
ESR1 estrogen receptor 1
FCGBP Fc fragment of IgG binding protein
FN1 fibronectin 1
GAS6 growth arrest-specific 6
GCC2 GRIP and coiled-coil domain containing 2
GJA1 gap junction protein, alpha 1, 43kDa
GPM6B glycoprotein M6B
GPR137B G protein-coupled receptor 137B
GRB7 growth factor receptor-bound protein 7
GRN granulin
HBP1 HMG-box transcription factor 1
HECA headcase homolog (Drosophila)
HIST3H2A histone cluster 3, H2a
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
IFI27 interferon, alpha-inducible protein 27
IGF1R insulin-like growth factor 1 receptor
IRS2 insulin receptor substrate 2
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
KLHDC2 kelch domain containing 2
LDLR low density lipoprotein receptor
LGALS3 lectin, galactoside-binding, soluble, 3
LINC00342 long intergenic non-protein coding RNA 342
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGED2 melanoma antigen family D2
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MTUS1 microtubule associated tumor suppressor 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPC1 Niemann-Pick disease, type C1
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PDE4B phosphodiesterase 4B, cAMP-specific
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
RAB31 RAB31, member RAS oncogene family
RBM47 RNA binding motif protein 47
RNASE4 ribonuclease, RNase A family, 4
RND3 Rho family GTPase 3
RTN2 reticulon 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A1 secretoglobin, family 2A, member 1
SEPP1 selenoprotein P, plasma, 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLC22A18 solute carrier family 22, member 18
SOX4 SRY (sex determining region Y)-box 4
SQSTM1 sequestosome 1
SRGN serglycin
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
SYT1 synaptotagmin I
TANK TRAF family member-associated NFKB activator
TBC1D15 TBC1 domain family, member 15
TBX3 T-box 3
TGIF1 TGFB-induced factor homeobox 1
TIMP2 TIMP metallopeptidase inhibitor 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSPAN4 tetraspanin 4
VNN1 vanin 1
ZNF185 zinc finger protein 185 (LIM domain)

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
AQP1 aquaporin 1 (Colton blood group)
ASPH aspartate beta-hydroxylase
ATF5 activating transcription factor 5
BZW2 basic leucine zipper and W2 domains 2
C1QBP complement component 1, q subcomponent binding protein
C3 complement component 3
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CENPU centromere protein U
COL15A1 collagen, type XV, alpha 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTSZ cathepsin Z
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
ENO1 enolase 1, (alpha)
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM216A family with sequence similarity 216, member A
FAM57A family with sequence similarity 57, member A
FASN fatty acid synthase
FEN1 flap structure-specific endonuclease 1
FHL1 four and a half LIM domains 1
G0S2 G0/G1 switch 2
GGCT gamma-glutamylcyclotransferase
GNAS GNAS complex locus
GREM1 gremlin 1, DAN family BMP antagonist
GSTM3 glutathione S-transferase mu 3 (brain)
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HK2 hexokinase 2
ICMT isoprenylcysteine carboxyl methyltransferase
IGFBP5 insulin-like growth factor binding protein 5
IGHD immunoglobulin heavy constant delta
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KPNB1 karyopherin (importin) beta 1
KRT13 keratin 13, type I
LDHB lactate dehydrogenase B
LIMCH1 LIM and calponin homology domains 1
LPL lipoprotein lipase
LRRC59 leucine rich repeat containing 59
MAOA monoamine oxidase A
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MPHOSPH6 M-phase phosphoprotein 6
MRPL12 mitochondrial ribosomal protein L12
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYH11 myosin, heavy chain 11, smooth muscle
NELFCD negative elongation factor complex member C/D
NME1 NME/NM23 nucleoside diphosphate kinase 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUP210 nucleoporin 210kDa
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCP4 Purkinje cell protein 4
PDE10A phosphodiesterase 10A
PDLIM3 PDZ and LIM domain 3
PFN2 profilin 2
PGM1 phosphoglucomutase 1
PLN phospholamban
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNP purine nucleoside phosphorylase
PPARG peroxisome proliferator-activated receptor gamma
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTDSS1 phosphatidylserine synthase 1
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RTN1 reticulon 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SFRP1 secreted frizzled-related protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SRM spermidine synthase
TCL1A T-cell leukemia/lymphoma 1A
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGFA transforming growth factor, alpha
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TRIP13 thyroid hormone receptor interactor 13
TUBB tubulin, beta class I
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZWINT ZW10 interacting kinetochore protein