BRD-A45498368_WYE-125132_A549_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

271 genes differentially expressed following the BRD-A45498368_WYE-125132_A549_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABLIM1 actin binding LIM protein 1
AGR2 anterior gradient 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMDHD2 amidohydrolase domain containing 2
ANXA4 annexin A4
AREG amphiregulin
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ATP9A ATPase, class II, type 9A
BEX1 brain expressed, X-linked 1
BTF3 basic transcription factor 3
C6ORF48 chromosome 6 open reading frame 48
C6ORF62 chromosome 6 open reading frame 62
CAMLG calcium modulating ligand
CAV2 caveolin 2
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CIRBP cold inducible RNA binding protein
CST1 cystatin SN
CTSA cathepsin A
CXCL8 chemokine (C-X-C motif) ligand 8
DOCK9 dedicator of cytokinesis 9
DUSP4 dual specificity phosphatase 4
EGFR epidermal growth factor receptor
EIF3D eukaryotic translation initiation factor 3, subunit D
EIF3E eukaryotic translation initiation factor 3, subunit E
EIF3M eukaryotic translation initiation factor 3, subunit M
EIF4B eukaryotic translation initiation factor 4B
EPAS1 endothelial PAS domain protein 1
EPS8 epidermal growth factor receptor pathway substrate 8
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM63A family with sequence similarity 63, member A
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL2 FOS-like antigen 2
FXR1 fragile X mental retardation, autosomal homolog 1
GALC galactosylceramidase
GATAD1 GATA zinc finger domain containing 1
GLTSCR2 glioma tumor suppressor candidate region gene 2
GOLGA8A golgin A8 family, member A
GOLGA8H golgin A8 family, member H
GPR137B G protein-coupled receptor 137B
GRN granulin
GSE1 Gse1 coiled-coil protein
HEBP1 heme binding protein 1
HIST3H2A histone cluster 3, H2a
HLA-E major histocompatibility complex, class I, E
HOPX HOP homeobox
IDS iduronate 2-sulfatase
IGBP1 immunoglobulin (CD79A) binding protein 1
IGF1R insulin-like growth factor 1 receptor
IL1R1 interleukin 1 receptor, type I
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JADE2 jade family PHD finger 2
KANK1 KN motif and ankyrin repeat domains 1
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KLF6 Kruppel-like factor 6
LAMA4 laminin, alpha 4
LETMD1 LETM1 domain containing 1
LGALS3 lectin, galactoside-binding, soluble, 3
LOX lysyl oxidase
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MET MET proto-oncogene, receptor tyrosine kinase
MGLL monoglyceride lipase
MNT MAX network transcriptional repressor
MTMR11 myotubularin related protein 11
MXI1 MAX interactor 1, dimerization protein
MYOF myoferlin
NBEA neurobeachin
NBR1 neighbor of BRCA1 gene 1
NPTX2 neuronal pentraxin II
NR4A2 nuclear receptor subfamily 4, group A, member 2
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
ORAI3 ORAI calcium release-activated calcium modulator 3
PAM peptidylglycine alpha-amidating monooxygenase
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDGFC platelet derived growth factor C
PDLIM5 PDZ and LIM domain 5
PGLS 6-phosphogluconolactonase
PLCB4 phospholipase C, beta 4
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PSCA prostate stem cell antigen
PTEN phosphatase and tensin homolog
QARS glutaminyl-tRNA synthetase
QPCT glutaminyl-peptide cyclotransferase
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RBKS ribokinase
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS5 regulator of G-protein signaling 5
RPL31 ribosomal protein L31
RPL36 ribosomal protein L36
RRAGD Ras-related GTP binding D
RSL1D1 ribosomal L1 domain containing 1
RSRP1 arginine/serine-rich protein 1
SAMD4A sterile alpha motif domain containing 4A
SATB1 SATB homeobox 1
SCAMP1 secretory carrier membrane protein 1
SDPR serum deprivation response
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC16A6 solute carrier family 16, member 6
SMAD3 SMAD family member 3
SMYD2 SET and MYND domain containing 2
SOX4 SRY (sex determining region Y)-box 4
STC1 stanniocalcin 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGM2 transglutaminase 2
THBS4 thrombospondin 4
TM4SF1 transmembrane 4 L six family member 1
TPCN1 two pore segment channel 1
TPP1 tripeptidyl peptidase I
TRAF5 TNF receptor-associated factor 5
TRAPPC6A trafficking protein particle complex 6A
TRIB2 tribbles pseudokinase 2
TRIM8 tripartite motif containing 8
USE1 unconventional SNARE in the ER 1 homolog (S. cerevisiae)
VAT1 vesicle amine transport 1
VDAC1 voltage-dependent anion channel 1
VWF von Willebrand factor
WDR45 WD repeat domain 45
YPEL5 yippee-like 5 (Drosophila)
ZNF185 zinc finger protein 185 (LIM domain)
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
AK1 adenylate kinase 1
AQP3 aquaporin 3 (Gill blood group)
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CA2 carbonic anhydrase II
CALML4 calmodulin-like 4
CCNA2 cyclin A2
CCNB2 cyclin B2
CCND3 cyclin D3
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHEK2 checkpoint kinase 2
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CKS1B CDC28 protein kinase regulatory subunit 1B
CSRP2 cysteine and glycine-rich protein 2
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL9 chemokine (C-X-C motif) ligand 9
DBF4 DBF4 zinc finger
DHCR24 24-dehydrocholesterol reductase
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EMP2 epithelial membrane protein 2
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
GAL galanin/GMAP prepropeptide
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPM6B glycoprotein M6B
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
H2AFZ H2A histone family, member Z
HAT1 histone acetyltransferase 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMMR hyaluronan-mediated motility receptor (RHAMM)
IDI1 isopentenyl-diphosphate delta isomerase 1
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
JCHAIN joining chain of multimeric IgA and IgM
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF4A kinesin family member 4A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT14 keratin 14, type I
KRT5 keratin 5, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LMNB1 lamin B1
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAN1A1 mannosidase, alpha, class 1A, member 1
MARS methionyl-tRNA synthetase
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MFAP4 microfibrillar-associated protein 4
MSX1 msh homeobox 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
OIP5 Opa interacting protein 5
ORC6 origin recognition complex, subunit 6
PBK PDZ binding kinase
PCP4 Purkinje cell protein 4
PEA15 phosphoprotein enriched in astrocytes 15
PHGDH phosphoglycerate dehydrogenase
PI3 peptidase inhibitor 3, skin-derived
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKCB protein kinase C, beta
PSAT1 phosphoserine aminotransferase 1
PSRC1 proline/serine-rich coiled-coil 1
RAD51C RAD51 paralog C
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RPA3 replication protein A3, 14kDa
RPN1 ribophorin I
RRM2 ribonucleotide reductase M2
S100A9 S100 calcium binding protein A9
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SDF2L1 stromal cell-derived factor 2-like 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLPI secretory leukocyte peptidase inhibitor
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SUB1 SUB1 homolog (S. cerevisiae)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TIMELESS timeless circadian clock
TK1 thymidine kinase 1, soluble
TMPO thymopoietin
TRIP13 thyroid hormone receptor interactor 13
TUBG1 tubulin, gamma 1
UBE2C ubiquitin-conjugating enzyme E2C
VRK1 vaccinia related kinase 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
ZWINT ZW10 interacting kinetochore protein