BRD-A45498368_WYE-125132_A549_24_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

186 genes differentially expressed following the BRD-A45498368_WYE-125132_A549_24_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AHNAK2 AHNAK nucleoprotein 2
AMDHD2 amidohydrolase domain containing 2
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA4 annexin A4
ARL4A ADP-ribosylation factor-like 4A
ASXL2 additional sex combs like transcriptional regulator 2
ATP9A ATPase, class II, type 9A
BCL6 B-cell CLL/lymphoma 6
BHLHE41 basic helix-loop-helix family, member e41
C1RL complement component 1, r subcomponent-like
CAMLG calcium modulating ligand
CCNG2 cyclin G2
CCPG1 cell cycle progression 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
COBL cordon-bleu WH2 repeat protein
COL18A1 collagen, type XVIII, alpha 1
COL4A1 collagen, type IV, alpha 1
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CST1 cystatin SN
CXCL8 chemokine (C-X-C motif) ligand 8
DOCK9 dedicator of cytokinesis 9
DPP4 dipeptidyl-peptidase 4
DPYD dihydropyrimidine dehydrogenase
DUSP4 dual specificity phosphatase 4
EGFR epidermal growth factor receptor
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ETV1 ets variant 1
F5 coagulation factor V (proaccelerin, labile factor)
FOSL2 FOS-like antigen 2
GLTSCR2 glioma tumor suppressor candidate region gene 2
GOLGA8A golgin A8 family, member A
GOLGA8H golgin A8 family, member H
GRN granulin
HBP1 HMG-box transcription factor 1
HEBP1 heme binding protein 1
IDS iduronate 2-sulfatase
IGBP1 immunoglobulin (CD79A) binding protein 1
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KIZ kizuna centrosomal protein
KRT7 keratin 7, type II
LAMA4 laminin, alpha 4
LAMC2 laminin, gamma 2
LGALS8 lectin, galactoside-binding, soluble, 8
LXN latexin
LY75 lymphocyte antigen 75
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K5 mitogen-activated protein kinase kinase 5
MET MET proto-oncogene, receptor tyrosine kinase
MGLL monoglyceride lipase
MTMR11 myotubularin related protein 11
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEBL nebulette
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OPTN optineurin
PAM peptidylglycine alpha-amidating monooxygenase
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDGFC platelet derived growth factor C
PLA2G16 phospholipase A2, group XVI
PLCB4 phospholipase C, beta 4
PNRC1 proline-rich nuclear receptor coactivator 1
PPL periplakin
PTCH1 patched 1
PTX3 pentraxin 3, long
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBKS ribokinase
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RPL36 ribosomal protein L36
RPL38 ribosomal protein L38
SDPR serum deprivation response
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SORBS2 sorbin and SH3 domain containing 2
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SULF1 sulfatase 1
TACC2 transforming, acidic coiled-coil containing protein 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
TM4SF1 transmembrane 4 L six family member 1
TM4SF4 transmembrane 4 L six family member 4
TRAPPC6A trafficking protein particle complex 6A
TTC3 tetratricopeptide repeat domain 3
VAT1 vesicle amine transport 1
VDAC1 voltage-dependent anion channel 1
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
WDR45 WD repeat domain 45
ZBTB20 zinc finger and BTB domain containing 20

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CA2 carbonic anhydrase II
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDKN3 cyclin-dependent kinase inhibitor 3
CENPN centromere protein N
CENPU centromere protein U
CIT citron rho-interacting serine/threonine kinase
CRABP2 cellular retinoic acid binding protein 2
CSRP2 cysteine and glycine-rich protein 2
CSTA cystatin A (stefin A)
DHCR24 24-dehydrocholesterol reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
E2F8 E2F transcription factor 8
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ENAH enabled homolog (Drosophila)
EXO1 exonuclease 1
FAM129A family with sequence similarity 129, member A
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
GAL galanin/GMAP prepropeptide
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GINS3 GINS complex subunit 3 (Psf3 homolog)
H2AFX H2A histone family, member X
HAT1 histone acetyltransferase 1
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KRT5 keratin 5, type II
LMNB1 lamin B1
LRRC59 leucine rich repeat containing 59
LSM1 LSM1, U6 small nuclear RNA associated
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MARS methionyl-tRNA synthetase
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MELK maternal embryonic leucine zipper kinase
MIS18A MIS18 kinetochore protein A
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NLRP2 NLR family, pyrin domain containing 2
NR2F6 nuclear receptor subfamily 2, group F, member 6
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
ORC6 origin recognition complex, subunit 6
PBK PDZ binding kinase
PHGDH phosphoglycerate dehydrogenase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PSPH phosphoserine phosphatase
PTGDS prostaglandin D2 synthase 21kDa (brain)
PYCR1 pyrroline-5-carboxylate reductase 1
RAD51 RAD51 recombinase
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM2 ribonucleotide reductase M2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SPC25 SPC25, NDC80 kinetochore complex component
TIMELESS timeless circadian clock
TK1 thymidine kinase 1, soluble
TMPO thymopoietin
TNNT1 troponin T type 1 (skeletal, slow)
TPSAB1 tryptase alpha/beta 1
TRIP13 thyroid hormone receptor interactor 13
TSPAN13 tetraspanin 13
TUBG1 tubulin, gamma 1
UBE2C ubiquitin-conjugating enzyme E2C
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein