BRD-A45498368_WYE-125132_A549_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

155 genes differentially expressed following the BRD-A45498368_WYE-125132_A549_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACTA2 actin, alpha 2, smooth muscle, aorta
ADCK3 aarF domain containing kinase 3
AKAP12 A kinase (PRKA) anchor protein 12
BEX1 brain expressed, X-linked 1
CA12 carbonic anhydrase XII
CADM1 cell adhesion molecule 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNG2 cyclin G2
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH17 cadherin 17, LI cadherin (liver-intestine)
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CHGB chromogranin B
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CTGF connective tissue growth factor
DUSP4 dual specificity phosphatase 4
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGFR epidermal growth factor receptor
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPAS1 endothelial PAS domain protein 1
F2R coagulation factor II (thrombin) receptor
FLNA filamin A, alpha
FNDC3B fibronectin type III domain containing 3B
FOLR1 folate receptor 1 (adult)
GLTSCR2 glioma tumor suppressor candidate region gene 2
GOLGA8H golgin A8 family, member H
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRN granulin
GSE1 Gse1 coiled-coil protein
GSN gelsolin
HOPX HOP homeobox
IGF1R insulin-like growth factor 1 receptor
IGFBP5 insulin-like growth factor binding protein 5
IQGAP1 IQ motif containing GTPase activating protein 1
IRS2 insulin receptor substrate 2
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
JAG1 jagged 1
KLF6 Kruppel-like factor 6
KRT7 keratin 7, type II
LAMC2 laminin, gamma 2
LAMP1 lysosomal-associated membrane protein 1
LRRC32 leucine rich repeat containing 32
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKS myristoylated alanine-rich protein kinase C substrate
MGP matrix Gla protein
MRPS16 mitochondrial ribosomal protein S16
MTMR11 myotubularin related protein 11
MXI1 MAX interactor 1, dimerization protein
MXRA7 matrix-remodelling associated 7
NBR1 neighbor of BRCA1 gene 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NPDC1 neural proliferation, differentiation and control, 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
PAM peptidylglycine alpha-amidating monooxygenase
PBX1 pre-B-cell leukemia homeobox 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PNMA2 paraneoplastic Ma antigen 2
PSAP prosaposin
PTCH1 patched 1
PTGIS prostaglandin I2 (prostacyclin) synthase
PTPRF protein tyrosine phosphatase, receptor type, F
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SNAP25 synaptosomal-associated protein, 25kDa
SOBP sine oculis binding protein homolog (Drosophila)
SOX4 SRY (sex determining region Y)-box 4
STX1A syntaxin 1A (brain)
SYT1 synaptotagmin I
SYT17 synaptotagmin XVII
TFPI2 tissue factor pathway inhibitor 2
TGM2 transglutaminase 2
TP53 tumor protein p53
TPP1 tripeptidyl peptidase I
TRAPPC6A trafficking protein particle complex 6A
TXNIP thioredoxin interacting protein
ZBTB38 zinc finger and BTB domain containing 38

decreased expression

Symbol Name
ABHD6 abhydrolase domain containing 6
ADI1 acireductone dioxygenase 1
ADRB2 adrenoceptor beta 2, surface
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BIRC5 baculoviral IAP repeat containing 5
CCL20 chemokine (C-C motif) ligand 20
CCNA2 cyclin A2
CD36 CD36 molecule (thrombospondin receptor)
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDKN3 cyclin-dependent kinase inhibitor 3
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CENPA centromere protein A
CENPN centromere protein N
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CSRP2 cysteine and glycine-rich protein 2
CSTA cystatin A (stefin A)
DHCR24 24-dehydrocholesterol reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
GPER1 G protein-coupled estrogen receptor 1
HOXC6 homeobox C6
IARS isoleucyl-tRNA synthetase
IFRD2 interferon-related developmental regulator 2
IL7R interleukin 7 receptor
ITM2A integral membrane protein 2A
KLK11 kallikrein-related peptidase 11
LTF lactotransferrin
MARS methionyl-tRNA synthetase
MCM10 minichromosome maintenance complex component 10
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCAPG non-SMC condensin I complex, subunit G
NCBP1 nuclear cap binding protein subunit 1, 80kDa
NMU neuromedin U
OIP5 Opa interacting protein 5
PBK PDZ binding kinase
PDZK1 PDZ domain containing 1
PHGDH phosphoglycerate dehydrogenase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
PRPF4 pre-mRNA processing factor 4
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
PSRC1 proline/serine-rich coiled-coil 1
RAD51C RAD51 paralog C
SC5D sterol-C5-desaturase
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SHCBP1 SHC SH2-domain binding protein 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STEAP1 six transmembrane epithelial antigen of the prostate 1
TACC3 transforming, acidic coiled-coil containing protein 3
TEX10 testis expressed 10
TK1 thymidine kinase 1, soluble
TLR4 toll-like receptor 4
TNC tenascin C
TUBB2A tubulin, beta 2A class IIa
TUBB6 tubulin, beta 6 class V
UBE2C ubiquitin-conjugating enzyme E2C
WARS tryptophanyl-tRNA synthetase