BRD-A45498368_WYE-125132_A375_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

220 genes differentially expressed following the BRD-A45498368_WYE-125132_A375_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
AGR2 anterior gradient 2
ALCAM activated leukocyte cell adhesion molecule
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit
ANKRD10 ankyrin repeat domain 10
ASS1 argininosuccinate synthase 1
ATF4 activating transcription factor 4
C6ORF48 chromosome 6 open reading frame 48
C7 complement component 7
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK7 cyclin-dependent kinase 7
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CSNK2A2 casein kinase 2, alpha prime polypeptide
CST1 cystatin SN
DDIT3 DNA-damage-inducible transcript 3
DEPTOR DEP domain containing MTOR-interacting protein
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EIF3F eukaryotic translation initiation factor 3, subunit F
EIF4B eukaryotic translation initiation factor 4B
FXR1 fragile X mental retardation, autosomal homolog 1
GAS6 growth arrest-specific 6
GATA2 GATA binding protein 2
GDF15 growth differentiation factor 15
GLTSCR2 glioma tumor suppressor candidate region gene 2
GSE1 Gse1 coiled-coil protein
GTPBP8 GTP-binding protein 8 (putative)
H2BFS H2B histone family, member S (pseudogene)
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BK histone cluster 1, H2bk
HIST3H2A histone cluster 3, H2a
HSPD1 heat shock 60kDa protein 1 (chaperonin)
ICAM1 intercellular adhesion molecule 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IPO7 importin 7
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KLHL24 kelch-like family member 24
LETMD1 LETM1 domain containing 1
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LY75 lymphocyte antigen 75
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MTA1 metastasis associated 1
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
N4BP2L1 NEDD4 binding protein 2-like 1
N4BP2L2 NEDD4 binding protein 2-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEB nebulin
NPC1 Niemann-Pick disease, type C1
NPDC1 neural proliferation, differentiation and control, 1
NUPR1 nuclear protein, transcriptional regulator, 1
OFD1 oral-facial-digital syndrome 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PDE4DIP phosphodiesterase 4D interacting protein
PEX11A peroxisomal biogenesis factor 11 alpha
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PTPN2 protein tyrosine phosphatase, non-receptor type 2
RAP1GAP RAP1 GTPase activating protein
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBKS ribokinase
RND3 Rho family GTPase 3
RNMT RNA (guanine-7-) methyltransferase
RPL22 ribosomal protein L22
RPL31 ribosomal protein L31
RSL1D1 ribosomal L1 domain containing 1
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SNX6 sorting nexin 6
SQSTM1 sequestosome 1
STX1A syntaxin 1A (brain)
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TNNC1 troponin C type 1 (slow)
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TPBG trophoblast glycoprotein
TSPAN4 tetraspanin 4
TSPAN8 tetraspanin 8
TTC3 tetratricopeptide repeat domain 3
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
XIST X inactive specific transcript (non-protein coding)
ZNF589 zinc finger protein 589
ZNF83 zinc finger protein 83

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ACTN1 actinin, alpha 1
ALDOC aldolase C, fructose-bisphosphate
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AREG amphiregulin
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARL4C ADP-ribosylation factor-like 4C
ASF1B anti-silencing function 1B histone chaperone
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CCNA2 cyclin A2
CCND3 cyclin D3
CCNE2 cyclin E2
CCNF cyclin F
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CIT citron rho-interacting serine/threonine kinase
CLCA4 chloride channel accessory 4
COL15A1 collagen, type XV, alpha 1
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COL4A5 collagen, type IV, alpha 5
CRABP2 cellular retinoic acid binding protein 2
CSRP2 cysteine and glycine-rich protein 2
CSTA cystatin A (stefin A)
CTSZ cathepsin Z
CXCL14 chemokine (C-X-C motif) ligand 14
DEFB1 defensin, beta 1
ECM1 extracellular matrix protein 1
EHD3 EH-domain containing 3
EMP2 epithelial membrane protein 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ESR1 estrogen receptor 1
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEN1 flap structure-specific endonuclease 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFBP1 fibroblast growth factor binding protein 1
FXYD3 FXYD domain containing ion transport regulator 3
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GMFG glia maturation factor, gamma
GNG11 guanine nucleotide binding protein (G protein), gamma 11
HES1 hes family bHLH transcription factor 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HLA-DRA major histocompatibility complex, class II, DR alpha
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
JAG1 jagged 1
KRT13 keratin 13, type I
KRT14 keratin 14, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAPTM5 lysosomal protein transmembrane 5
LMNB1 lamin B1
LMO2 LIM domain only 2 (rhombotin-like 1)
LTF lactotransferrin
LUM lumican
MARCKSL1 MARCKS-like 1
MCM10 minichromosome maintenance complex component 10
MEGF9 multiple EGF-like-domains 9
MELK maternal embryonic leucine zipper kinase
MMP2 matrix metallopeptidase 2
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYH10 myosin, heavy chain 10, non-muscle
NES nestin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NID1 nidogen 1
NREP neuronal regeneration related protein
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUSAP1 nucleolar and spindle associated protein 1
PEG10 paternally expressed 10
PELI1 pellino E3 ubiquitin protein ligase 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAT plasminogen activator, tissue
PLP1 proteolipid protein 1
POSTN periostin, osteoblast specific factor
PRR15L proline rich 15-like
PTN pleiotrophin
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
PXMP2 peroxisomal membrane protein 2, 22kDa
RBX1 ring-box 1, E3 ubiquitin protein ligase
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGCC regulator of cell cycle
RIN2 Ras and Rab interactor 2
RRM2 ribonucleotide reductase M2
S100A4 S100 calcium binding protein A4
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100B S100 calcium binding protein B
SELT selenoprotein T
SFN stratifin
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SNN stannin
SNRK SNF related kinase
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK5 serine peptidase inhibitor, Kazal type 5
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPRR3 small proline-rich protein 3
SYNM synemin, intermediate filament protein
TACSTD2 tumor-associated calcium signal transducer 2
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TGFA transforming growth factor, alpha
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TIMP3 TIMP metallopeptidase inhibitor 3
TLR4 toll-like receptor 4
TMEM2 transmembrane protein 2
TMPO thymopoietin
TMX4 thioredoxin-related transmembrane protein 4
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
VSNL1 visinin-like 1
WFDC2 WAP four-disulfide core domain 2
ZFP36L1 ZFP36 ring finger protein-like 1
ZWINT ZW10 interacting kinetochore protein