BRD-A45498368_WYE-125132_A375_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

192 genes differentially expressed following the BRD-A45498368_WYE-125132_A375_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHNAK2 AHNAK nucleoprotein 2
ANK2 ankyrin 2, neuronal
ANXA4 annexin A4
ATF4 activating transcription factor 4
C6ORF48 chromosome 6 open reading frame 48
C6ORF62 chromosome 6 open reading frame 62
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAMLG calcium modulating ligand
CAPN3 calpain 3, (p94)
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCL8 chemokine (C-C motif) ligand 8
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH17 cadherin 17, LI cadherin (liver-intestine)
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CELF2 CUGBP, Elav-like family member 2
COL14A1 collagen, type XIV, alpha 1
COL16A1 collagen, type XVI, alpha 1
COL8A2 collagen, type VIII, alpha 2
COMP cartilage oligomeric matrix protein
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSNK2A2 casein kinase 2, alpha prime polypeptide
CTGF connective tissue growth factor
CTSK cathepsin K
CXCL3 chemokine (C-X-C motif) ligand 3
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DPEP1 dipeptidase 1 (renal)
EIF2D eukaryotic translation initiation factor 2D
EIF3G eukaryotic translation initiation factor 3, subunit G
EIF3M eukaryotic translation initiation factor 3, subunit M
EIF4B eukaryotic translation initiation factor 4B
EMP1 epithelial membrane protein 1
ERAP2 endoplasmic reticulum aminopeptidase 2
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
GAB2 GRB2-associated binding protein 2
GATAD1 GATA zinc finger domain containing 1
GDF15 growth differentiation factor 15
GLTSCR2 glioma tumor suppressor candidate region gene 2
GREM1 gremlin 1, DAN family BMP antagonist
GSE1 Gse1 coiled-coil protein
HEBP1 heme binding protein 1
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HMGA2 high mobility group AT-hook 2
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IGBP1 immunoglobulin (CD79A) binding protein 1
IGF2R insulin-like growth factor 2 receptor
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
INHBA inhibin, beta A
IPO7 importin 7
IRF7 interferon regulatory factor 7
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KARS lysyl-tRNA synthetase
KLF5 Kruppel-like factor 5 (intestinal)
KYNU kynureninase
LEF1 lymphoid enhancer-binding factor 1
LETMD1 LETM1 domain containing 1
LGALS9 lectin, galactoside-binding, soluble, 9
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LONP2 lon peptidase 2, peroxisomal
LRRC16A leucine rich repeat containing 16A
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MFAP5 microfibrillar associated protein 5
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
MMP3 matrix metallopeptidase 3
MX1 MX dynamin-like GTPase 1
MXI1 MAX interactor 1, dimerization protein
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NONO non-POU domain containing, octamer-binding
NPC1 Niemann-Pick disease, type C1
NPDC1 neural proliferation, differentiation and control, 1
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRN1 neuritin 1
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form)
PDE4DIP phosphodiesterase 4D interacting protein
PERP PERP, TP53 apoptosis effector
PGLS 6-phosphogluconolactonase
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PLAGL1 pleiomorphic adenoma gene-like 1
PLCB4 phospholipase C, beta 4
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PRAME preferentially expressed antigen in melanoma
QARS glutaminyl-tRNA synthetase
RBKS ribokinase
REG1A regenerating islet-derived 1 alpha
RGS10 regulator of G-protein signaling 10
RGS20 regulator of G-protein signaling 20
RPL22 ribosomal protein L22
RPL36 ribosomal protein L36
RPS2 ribosomal protein S2
RSL1D1 ribosomal L1 domain containing 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SNAI2 snail family zinc finger 2
SOD2 superoxide dismutase 2, mitochondrial
SQSTM1 sequestosome 1
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TCEAL4 transcription elongation factor A (SII)-like 4
TMEM63A transmembrane protein 63A
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TOX3 TOX high mobility group box family member 3
TPM2 tropomyosin 2 (beta)
TPP1 tripeptidyl peptidase I
TPSAB1 tryptase alpha/beta 1
TSC22D1 TSC22 domain family, member 1
TTC37 tetratricopeptide repeat domain 37
USE1 unconventional SNARE in the ER 1 homolog (S. cerevisiae)
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
WISP2 WNT1 inducible signaling pathway protein 2
YBX3 Y box binding protein 3
ZFAND1 zinc finger, AN1-type domain 1
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDOC aldolase C, fructose-bisphosphate
ARG2 arginase 2
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATAD2 ATPase family, AAA domain containing 2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
AURKA aurora kinase A
CCDC109B coiled-coil domain containing 109B
CCNA2 cyclin A2
CCND3 cyclin D3
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CLU clusterin
CSRP2 cysteine and glycine-rich protein 2
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EFHD1 EF-hand domain family, member D1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EXT1 exostosin glycosyltransferase 1
FEN1 flap structure-specific endonuclease 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GSTA1 glutathione S-transferase alpha 1
GTSE1 G-2 and S-phase expressed 1
GUCY1B3 guanylate cyclase 1, soluble, beta 3
H2AFX H2A histone family, member X
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
IDI1 isopentenyl-diphosphate delta isomerase 1
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KIF20A kinesin family member 20A
LMNB1 lamin B1
LMO2 LIM domain only 2 (rhombotin-like 1)
MATN2 matrilin 2
MCM10 minichromosome maintenance complex component 10
MEGF9 multiple EGF-like-domains 9
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NCAPH non-SMC condensin I complex, subunit H
NEFL neurofilament, light polypeptide
NES nestin
NRGN neurogranin (protein kinase C substrate, RC3)
NUSAP1 nucleolar and spindle associated protein 1
PCCB propionyl CoA carboxylase, beta polypeptide
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PGAM1 phosphoglycerate mutase 1 (brain)
PLAT plasminogen activator, tissue
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PODXL podocalyxin-like
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PXDN peroxidasin
RBX1 ring-box 1, E3 ubiquitin protein ligase
RGS2 regulator of G-protein signaling 2
S100A4 S100 calcium binding protein A4
SELT selenoprotein T
SEPP1 selenoprotein P, plasma, 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SQRDL sulfide quinone reductase-like (yeast)
TACC1 transforming, acidic coiled-coil containing protein 1
TF transferrin
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TSPAN13 tetraspanin 13
TUBG1 tubulin, gamma 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ZFP36L1 ZFP36 ring finger protein-like 1