BRD-A45498368_WYE-125132_A375_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

152 genes differentially expressed following the BRD-A45498368_WYE-125132_A375_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABLIM1 actin binding LIM protein 1
AHCY adenosylhomocysteinase
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANO1 anoctamin 1, calcium activated chloride channel
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
ATP9A ATPase, class II, type 9A
BTF3 basic transcription factor 3
C14ORF159 chromosome 14 open reading frame 159
C6ORF48 chromosome 6 open reading frame 48
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAMLG calcium modulating ligand
CCL5 chemokine (C-C motif) ligand 5
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCND1 cyclin D1
CCND2 cyclin D2
CD24 CD24 molecule
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CRTAP cartilage associated protein
CSNK2A2 casein kinase 2, alpha prime polypeptide
CST1 cystatin SN
DKK3 dickkopf WNT signaling pathway inhibitor 3
EDN1 endothelin 1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF3F eukaryotic translation initiation factor 3, subunit F
EIF3M eukaryotic translation initiation factor 3, subunit M
EIF4A2 eukaryotic translation initiation factor 4A2
EIF4B eukaryotic translation initiation factor 4B
EIF5A eukaryotic translation initiation factor 5A
ERAP1 endoplasmic reticulum aminopeptidase 1
ERCC1 excision repair cross-complementation group 1
F2R coagulation factor II (thrombin) receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
GLTSCR2 glioma tumor suppressor candidate region gene 2
GOLGA8A golgin A8 family, member A
GSDMB gasdermin B
HDAC9 histone deacetylase 9
HEBP1 heme binding protein 1
HIGD2A HIG1 hypoxia inducible domain family, member 2A
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-E major histocompatibility complex, class I, E
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IGBP1 immunoglobulin (CD79A) binding protein 1
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
ITGA6 integrin, alpha 6
KARS lysyl-tRNA synthetase
KLF6 Kruppel-like factor 6
LETMD1 LETM1 domain containing 1
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LRPPRC leucine-rich pentatricopeptide repeat containing
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K5 mitogen-activated protein kinase kinase 5
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAP1L1 nucleosome assembly protein 1-like 1
NELL2 NEL-like 2 (chicken)
NET1 neuroepithelial cell transforming 1
NPDC1 neural proliferation, differentiation and control, 1
NRN1 neuritin 1
NT5E 5'-nucleotidase, ecto (CD73)
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PFKL phosphofructokinase, liver
PGLS 6-phosphogluconolactonase
PLA1A phospholipase A1 member A
PLCB4 phospholipase C, beta 4
PRKCQ protein kinase C, theta
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTPRO protein tyrosine phosphatase, receptor type, O
QARS glutaminyl-tRNA synthetase
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1
RGS10 regulator of G-protein signaling 10
RNASE4 ribonuclease, RNase A family, 4
RPL15 ribosomal protein L15
RPL36 ribosomal protein L36
RSRP1 arginine/serine-rich protein 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SATB1 SATB homeobox 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SYT1 synaptotagmin I
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TFPI2 tissue factor pathway inhibitor 2
TP53 tumor protein p53
TPP1 tripeptidyl peptidase I
TSPAN4 tetraspanin 4
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ALDOC aldolase C, fructose-bisphosphate
ALOX5 arachidonate 5-lipoxygenase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AURKA aurora kinase A
BASP1 brain abundant, membrane attached signal protein 1
BCAT1 branched chain amino-acid transaminase 1, cytosolic
CCND3 cyclin D3
CDC25A cell division cycle 25A
CDKN3 cyclin-dependent kinase inhibitor 3
CREB1 cAMP responsive element binding protein 1
CSRP1 cysteine and glycine-rich protein 1
CTSZ cathepsin Z
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DSE dermatan sulfate epimerase
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAM46A family with sequence similarity 46, member A
FGFR3 fibroblast growth factor receptor 3
FOLR1 folate receptor 1 (adult)
GPX3 glutathione peroxidase 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA1A heat shock 70kDa protein 1A
HSPB8 heat shock 22kDa protein 8
IDI1 isopentenyl-diphosphate delta isomerase 1
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
ITGB1BP1 integrin beta 1 binding protein 1
JADE2 jade family PHD finger 2
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LPCAT1 lysophosphatidylcholine acyltransferase 1
LTF lactotransferrin
MAP7 microtubule-associated protein 7
MATN2 matrilin 2
MREG melanoregulin
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NUSAP1 nucleolar and spindle associated protein 1
PDZK1 PDZ domain containing 1
PEG10 paternally expressed 10
PELI1 pellino E3 ubiquitin protein ligase 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PKM pyruvate kinase, muscle
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PTN pleiotrophin
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RIT1 Ras-like without CAAX 1
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SESN1 sestrin 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TNS1 tensin 1
TPM4 tropomyosin 4
TUBG1 tubulin, gamma 1
VTCN1 V-set domain containing T cell activation inhibitor 1