BRD-A45498368_HY-10044_PHH_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

120 genes differentially expressed following the BRD-A45498368_HY-10044_PHH_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AHNAK AHNAK nucleoprotein
APOD apolipoprotein D
AQP3 aquaporin 3 (Gill blood group)
BASP1 brain abundant, membrane attached signal protein 1
CAV1 caveolin 1, caveolae protein, 22kDa
CDC25B cell division cycle 25B
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CIRBP cold inducible RNA binding protein
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CNPPD1 cyclin Pas1/PHO80 domain containing 1
CPM carboxypeptidase M
CYBRD1 cytochrome b reductase 1
DLX2 distal-less homeobox 2
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNMBP dynamin binding protein
DRAM1 DNA-damage regulated autophagy modulator 1
G0S2 G0/G1 switch 2
GADD45B growth arrest and DNA-damage-inducible, beta
GDF15 growth differentiation factor 15
IGFBP4 insulin-like growth factor binding protein 4
IRS2 insulin receptor substrate 2
ITGB5 integrin, beta 5
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
LAMP1 lysosomal-associated membrane protein 1
LIMA1 LIM domain and actin binding 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MGLL monoglyceride lipase
MSLN mesothelin
MYC v-myc avian myelocytomatosis viral oncogene homolog
OSR2 odd-skipped related transciption factor 2
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PIEZO1 piezo-type mechanosensitive ion channel component 1
PXDC1 PX domain containing 1
RNPS1 RNA binding protein S1, serine-rich domain
SASH1 SAM and SH3 domain containing 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFTPC surfactant protein C
SGCE sarcoglycan, epsilon
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SPTBN1 spectrin, beta, non-erythrocytic 1
SRGN serglycin
STC1 stanniocalcin 1
TGM2 transglutaminase 2
TSC22D3 TSC22 domain family, member 3
WNK1 WNK lysine deficient protein kinase 1
WSB1 WD repeat and SOCS box containing 1
ZNF318 zinc finger protein 318

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASNS asparagine synthetase (glutamine-hydrolyzing)
BEX1 brain expressed, X-linked 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CBR1 carbonyl reductase 1
CCNA2 cyclin A2
CCND1 cyclin D1
CD24 CD24 molecule
CDC20 cell division cycle 20
CFB complement factor B
CLC Charcot-Leyden crystal galectin
CLU clusterin
COL1A2 collagen, type I, alpha 2
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous)
CSNK1A1 casein kinase 1, alpha 1
CST7 cystatin F (leukocystatin)
CXCL13 chemokine (C-X-C motif) ligand 13
DEFB1 defensin, beta 1
DHCR7 7-dehydrocholesterol reductase
DLK1 delta-like 1 homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FDFT1 farnesyl-diphosphate farnesyltransferase 1
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GCH1 GTP cyclohydrolase 1
GOLGA8B golgin A8 family, member B
GPI glucose-6-phosphate isomerase
GSTA1 glutathione S-transferase alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IDI1 isopentenyl-diphosphate delta isomerase 1
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
KRT6B keratin 6B, type II
LRRC17 leucine rich repeat containing 17
LTF lactotransferrin
MGP matrix Gla protein
MSMO1 methylsterol monooxygenase 1
MTCL1 microtubule crosslinking factor 1
MXRA5 matrix-remodelling associated 5
MYCBP MYC binding protein
NDN necdin, melanoma antigen (MAGE) family member
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa
NELL2 NEL-like 2 (chicken)
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NPY1R neuropeptide Y receptor Y1
NT5DC2 5'-nucleotidase domain containing 2
PBX1 pre-B-cell leukemia homeobox 1
PEG3 paternally expressed 3
PFN2 profilin 2
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PPA2 pyrophosphatase (inorganic) 2
PSENEN presenilin enhancer gamma secretase subunit
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RPS21 ribosomal protein S21
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEPP1 selenoprotein P, plasma, 1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SOX11 SRY (sex determining region Y)-box 11
SPRR3 small proline-rich protein 3
SQLE squalene epoxidase
TBCB tubulin folding cofactor B
TMEM97 transmembrane protein 97
TPD52L1 tumor protein D52-like 1
TSPAN13 tetraspanin 13
TUSC3 tumor suppressor candidate 3
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1