BRD-A44008656_DOXYLAMINE SUCCINATE_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

108 genes differentially expressed following the BRD-A44008656_DOXYLAMINE SUCCINATE_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
ADM adrenomedullin
ALOX5 arachidonate 5-lipoxygenase
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BLNK B-cell linker
CAMP cathelicidin antimicrobial peptide
CD200 CD200 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CKAP4 cytoskeleton-associated protein 4
CLC Charcot-Leyden crystal galectin
CLIC3 chloride intracellular channel 3
COL1A2 collagen, type I, alpha 2
CTNND1 catenin (cadherin-associated protein), delta 1
DEFA4 defensin, alpha 4, corticostatin
DLK1 delta-like 1 homolog (Drosophila)
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
FABP4 fatty acid binding protein 4, adipocyte
FGFR2 fibroblast growth factor receptor 2
FRZB frizzled-related protein
FSD1 fibronectin type III and SPRY domain containing 1
FXYD3 FXYD domain containing ion transport regulator 3
FZD10 frizzled class receptor 10
FZD5 frizzled class receptor 5
GULP1 GULP, engulfment adaptor PTB domain containing 1
HAT1 histone acetyltransferase 1
HBB hemoglobin, beta
HK2 hexokinase 2
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
HSPA2 heat shock 70kDa protein 2
HSPA4 heat shock 70kDa protein 4
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IPO13 importin 13
ITM2C integral membrane protein 2C
JCHAIN joining chain of multimeric IgA and IgM
LAMP3 lysosomal-associated membrane protein 3
LGALS4 lectin, galactoside-binding, soluble, 4
MEF2C myocyte enhancer factor 2C
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MX1 MX dynamin-like GTPase 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
OLFM4 olfactomedin 4
ORC1 origin recognition complex, subunit 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PPAP2B phosphatidic acid phosphatase type 2B
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PPP1R13B protein phosphatase 1, regulatory subunit 13B
RAB21 RAB21, member RAS oncogene family
RGCC regulator of cell cycle
S100A8 S100 calcium binding protein A8
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRGN serglycin
SYNGR1 synaptogyrin 1
TESK1 testis-specific kinase 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNNT1 troponin T type 1 (skeletal, slow)
UBE2J1 ubiquitin-conjugating enzyme E2, J1
UBQLN2 ubiquilin 2
XIST X inactive specific transcript (non-protein coding)
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AGR2 anterior gradient 2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
BIK BCL2-interacting killer (apoptosis-inducing)
BMI1 BMI1 proto-oncogene, polycomb ring finger
BST2 bone marrow stromal cell antigen 2
BZW2 basic leucine zipper and W2 domains 2
C1S complement component 1, s subcomponent
COL15A1 collagen, type XV, alpha 1
COL4A2 collagen, type IV, alpha 2
CYR61 cysteine-rich, angiogenic inducer, 61
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNB2 ephrin-B2
FAM46A family with sequence similarity 46, member A
FASTKD5 FAST kinase domains 5
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GAS1 growth arrest-specific 1
GPX3 glutathione peroxidase 3
HOXC6 homeobox C6
IL18 interleukin 18
ITM2A integral membrane protein 2A
NFIB nuclear factor I/B
NPY neuropeptide Y
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PROM1 prominin 1
PRSS23 protease, serine, 23
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RPS4Y1 ribosomal protein S4, Y-linked 1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS4 thrombospondin 4
TM9SF3 transmembrane 9 superfamily member 3
TSPAN13 tetraspanin 13