BRD-A43640821_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

242 genes differentially expressed following the BRD-A43640821_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD6 abhydrolase domain containing 6
ABLIM3 actin binding LIM protein family, member 3
APOA4 apolipoprotein A-IV
BEX1 brain expressed, X-linked 1
CADM1 cell adhesion molecule 1
CALR calreticulin
CAPN2 calpain 2, (m/II) large subunit
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHN1 chimerin 1
COL6A2 collagen, type VI, alpha 2
COLEC12 collectin sub-family member 12
CST6 cystatin E/M
DEFA5 defensin, alpha 5, Paneth cell-specific
DHRS2 dehydrogenase/reductase (SDR family) member 2
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
F13A1 coagulation factor XIII, A1 polypeptide
FABP6 fatty acid binding protein 6, ileal
FCGBP Fc fragment of IgG binding protein
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
FSCN1 fascin actin-bundling protein 1
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GAL galanin/GMAP prepropeptide
GAS6 growth arrest-specific 6
GUSBP11 glucuronidase, beta pseudogene 11
H2BFS H2B histone family, member S (pseudogene)
HBE1 hemoglobin, epsilon 1
HIST1H1C histone cluster 1, H1c
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST2H2BE histone cluster 2, H2be
HOMER3 homer scaffolding protein 3
HPCAL1 hippocalcin-like 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
IL1R2 interleukin 1 receptor, type II
KRT20 keratin 20, type I
LAPTM5 lysosomal protein transmembrane 5
LOC100286895 cell division cycle 27 homolog pseudogene
MAGEB2 melanoma antigen family B2
MGP matrix Gla protein
MMP11 matrix metallopeptidase 11
MMP12 matrix metallopeptidase 12
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NCAM1 neural cell adhesion molecule 1
NEB nebulin
NELFCD negative elongation factor complex member C/D
NELL2 NEL-like 2 (chicken)
PDLIM3 PDZ and LIM domain 3
PLEK2 pleckstrin 2
PLVAP plasmalemma vesicle associated protein
RAB2A RAB2A, member RAS oncogene family
RAMP1 receptor (G protein-coupled) activity modifying protein 1
REG3A regenerating islet-derived 3 alpha
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SCD5 stearoyl-CoA desaturase 5
SFRP1 secreted frizzled-related protein 1
SRGN serglycin
STC1 stanniocalcin 1
TGFBI transforming growth factor, beta-induced, 68kDa
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TPM4 tropomyosin 4
TRIB2 tribbles pseudokinase 2
TTN titin
VEGFA vascular endothelial growth factor A
WNT5A wingless-type MMTV integration site family, member 5A
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ABI1 abl-interactor 1
AMD1 adenosylmethionine decarboxylase 1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARHGAP29 Rho GTPase activating protein 29
ARMCX1 armadillo repeat containing, X-linked 1
ARMCX2 armadillo repeat containing, X-linked 2
ARMCX6 armadillo repeat containing, X-linked 6
ARMT1 acidic residue methyltransferase 1
ATF1 activating transcription factor 1
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
BASP1 brain abundant, membrane attached signal protein 1
BIRC5 baculoviral IAP repeat containing 5
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C6ORF62 chromosome 6 open reading frame 62
C8ORF4 chromosome 8 open reading frame 4
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2
CDK1 cyclin-dependent kinase 1
CDK4 cyclin-dependent kinase 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CELF2 CUGBP, Elav-like family member 2
CEP55 centrosomal protein 55kDa
CHEK2 checkpoint kinase 2
CHPT1 choline phosphotransferase 1
CLINT1 clathrin interactor 1
CP ceruloplasmin (ferroxidase)
CTSH cathepsin H
CTSK cathepsin K
CXCL12 chemokine (C-X-C motif) ligand 12
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCK deoxycytidine kinase
DEFB1 defensin, beta 1
DEK DEK proto-oncogene
DLD dihydrolipoamide dehydrogenase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DYNLT3 dynein, light chain, Tctex-type 3
EED embryonic ectoderm development
EGR3 early growth response 3
EIF1AX eukaryotic translation initiation factor 1A, X-linked
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4
ERBB3 erb-b2 receptor tyrosine kinase 3
FAM134B family with sequence similarity 134, member B
FANCI Fanconi anemia, complementation group I
FOXJ3 forkhead box J3
G0S2 G0/G1 switch 2
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
G3BP2 GTPase activating protein (SH3 domain) binding protein 2
GCH1 GTP cyclohydrolase 1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GMFB glia maturation factor, beta
GPX3 glutathione peroxidase 3
GSPT2 G1 to S phase transition 2
GTPBP8 GTP-binding protein 8 (putative)
GULP1 GULP, engulfment adaptor PTB domain containing 1
HACD2 3-hydroxyacyl-CoA dehydratase 2
HDGFRP3 hepatoma-derived growth factor, related protein 3
HLF hepatic leukemia factor
HLTF helicase-like transcription factor
HNMT histamine N-methyltransferase
HOXC6 homeobox C6
HOXD1 homeobox D1
HPRT1 hypoxanthine phosphoribosyltransferase 1
IGF1R insulin-like growth factor 1 receptor
IPO7 importin 7
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF2C kinesin family member 2C
KLF4 Kruppel-like factor 4 (gut)
KRT14 keratin 14, type I
LACTB2 lactamase, beta 2
LUC7L3 LUC7-like 3 (S. cerevisiae)
LYPLA1 lysophospholipase I
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MARCKS myristoylated alanine-rich protein kinase C substrate
MBP myelin basic protein
MEGF9 multiple EGF-like-domains 9
MELK maternal embryonic leucine zipper kinase
MET MET proto-oncogene, receptor tyrosine kinase
METTL21B methyltransferase like 21B
MGLL monoglyceride lipase
MOAP1 modulator of apoptosis 1
MPZL1 myelin protein zero-like 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MUC1 mucin 1, cell surface associated
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase
MYH10 myosin, heavy chain 10, non-muscle
MYO5C myosin VC
NAV2 neuron navigator 2
NBN nibrin
NFIB nuclear factor I/B
NOTCH2NL notch 2 N-terminal like
NQO1 NAD(P)H dehydrogenase, quinone 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
OXR1 oxidation resistance 1
OXTR oxytocin receptor
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PEG10 paternally expressed 10
PLS1 plastin 1
PRDX1 peroxiredoxin 1
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRPF4 pre-mRNA processing factor 4
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
RAB40B RAB40B, member RAS oncogene family
RACGAP1 Rac GTPase activating protein 1
RAD51AP1 RAD51 associated protein 1
RAD54B RAD54 homolog B (S. cerevisiae)
RBBP8 retinoblastoma binding protein 8
RBM3 RNA binding motif (RNP1, RRM) protein 3
RBM47 RNA binding motif protein 47
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RNF167 ring finger protein 167
RPS4Y1 ribosomal protein S4, Y-linked 1
RRP1B ribosomal RNA processing 1B
SAMD4A sterile alpha motif domain containing 4A
SEH1L SEH1-like (S. cerevisiae)
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SGCE sarcoglycan, epsilon
SGK1 serum/glucocorticoid regulated kinase 1
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC25A46 solute carrier family 25, member 46
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMC2 structural maintenance of chromosomes 2
SMS spermine synthase
SRSF11 serine/arginine-rich splicing factor 11
STC2 stanniocalcin 2
STK39 serine threonine kinase 39
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TJP2 tight junction protein 2
TM2D3 TM2 domain containing 3
TMEM126B transmembrane protein 126B
TMEM165 transmembrane protein 165
TMEM251 transmembrane protein 251
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOP2A topoisomerase (DNA) II alpha 170kDa
TSNAX translin-associated factor X
TSPAN31 tetraspanin 31
TSPYL1 TSPY-like 1
TSPYL5 TSPY-like 5
TXNDC9 thioredoxin domain containing 9
UBE2C ubiquitin-conjugating enzyme E2C
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGCG UDP-glucose ceramide glucosyltransferase
USP1 ubiquitin specific peptidase 1
VRK1 vaccinia related kinase 1
WFDC2 WAP four-disulfide core domain 2
XBP1 X-box binding protein 1
XPO1 exportin 1
XPO7 exportin 7
YME1L1 YME1-like 1 ATPase
ZMYM2 zinc finger, MYM-type 2