BRD-A43155244_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

76 genes differentially expressed following the BRD-A43155244_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ATF3 activating transcription factor 3
AXL AXL receptor tyrosine kinase
BTG2 BTG family, member 2
CAST calpastatin
CLU clusterin
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP2 dual specificity phosphatase 2
EDNRA endothelin receptor type A
EMX2 empty spiracles homeobox 2
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GULP1 GULP, engulfment adaptor PTB domain containing 1
HEPH hephaestin
HIC2 hypermethylated in cancer 2
HIST1H1C histone cluster 1, H1c
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
HPCAL1 hippocalcin-like 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IL1R2 interleukin 1 receptor, type II
JUN jun proto-oncogene
LDHB lactate dehydrogenase B
LEF1 lymphoid enhancer-binding factor 1
LOC100505650 uncharacterized LOC100505650
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
ODC1 ornithine decarboxylase 1
PCSK1 proprotein convertase subtilisin/kexin type 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PRAME preferentially expressed antigen in melanoma
RGCC regulator of cell cycle
SCG5 secretogranin V
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SIK1 salt-inducible kinase 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SRGN serglycin
TXNIP thioredoxin interacting protein
TXNRD1 thioredoxin reductase 1
WNT5A wingless-type MMTV integration site family, member 5A
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
B3GNT1
BAMBI BMP and activin membrane-bound inhibitor
CA12 carbonic anhydrase XII
CANT1 calcium activated nucleotidase 1
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GATA3 GATA binding protein 3
GINS1 GINS complex subunit 1 (Psf1 homolog)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
KRT14 keratin 14, type I
KRT23 keratin 23, type I
LAPTM4B lysosomal protein transmembrane 4 beta
MKL2 MKL/myocardin-like 2
MREG melanoregulin
NFIB nuclear factor I/B
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRIP1 nuclear receptor interacting protein 1
PCNA proliferating cell nuclear antigen
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
SCAND1 SCAN domain containing 1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SOX4 SRY (sex determining region Y)-box 4
SPDEF SAM pointed domain containing ETS transcription factor
TACSTD2 tumor-associated calcium signal transducer 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
UBE2C ubiquitin-conjugating enzyme E2C
ZNF91 zinc finger protein 91