BRD-A43155244_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

302 genes differentially expressed following the BRD-A43155244_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ANKRD11 ankyrin repeat domain 11
ANXA1 annexin A1
ATF3 activating transcription factor 3
ATG12 autophagy related 12
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AZU1 azurocidin 1
BRD2 bromodomain containing 2
CA1 carbonic anhydrase I
CCL5 chemokine (C-C motif) ligand 5
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLC Charcot-Leyden crystal galectin
COL6A2 collagen, type VI, alpha 2
CPA3 carboxypeptidase A3 (mast cell)
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DEFA4 defensin, alpha 4, corticostatin
DLX2 distal-less homeobox 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EDN3 endothelin 3
EGR1 early growth response 1
ELANE elastase, neutrophil expressed
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPAS1 endothelial PAS domain protein 1
ETV5 ets variant 5
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL1 FOS-like antigen 1
FOXO1 forkhead box O1
G0S2 G0/G1 switch 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GAGE3 G antigen 3
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GEM GTP binding protein overexpressed in skeletal muscle
GPRC5A G protein-coupled receptor, class C, group 5, member A
HBEGF heparin-binding EGF-like growth factor
HECA headcase homolog (Drosophila)
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HOMER3 homer scaffolding protein 3
HP haptoglobin
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
INSR insulin receptor
JAG1 jagged 1
JUN jun proto-oncogene
KCTD5 potassium channel tetramerization domain containing 5
KDM3A lysine (K)-specific demethylase 3A
KLHL24 kelch-like family member 24
KLRB1 killer cell lectin-like receptor subfamily B, member 1
LCK LCK proto-oncogene, Src family tyrosine kinase
LCN2 lipocalin 2
LGALS3 lectin, galactoside-binding, soluble, 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MED17 mediator complex subunit 17
MICB MHC class I polypeptide-related sequence B
MIR22HG MIR22 host gene
MPO myeloperoxidase
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NBPF10 neuroblastoma breakpoint family, member 10
NCAM1 neural cell adhesion molecule 1
NDRG1 N-myc downstream regulated 1
NEU1 sialidase 1 (lysosomal sialidase)
NR4A3 nuclear receptor subfamily 4, group A, member 3
NT5E 5'-nucleotidase, ecto (CD73)
NXF1 nuclear RNA export factor 1
OLFM4 olfactomedin 4
PCDH17 protocadherin 17
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEG3 paternally expressed 3
PERP PERP, TP53 apoptosis effector
PLAUR plasminogen activator, urokinase receptor
PLIN2 perilipin 2
POPDC3 popeye domain containing 3
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRF1 perforin 1 (pore forming protein)
PRRC2C proline-rich coiled-coil 2C
PRTN3 proteinase 3
RGS2 regulator of G-protein signaling 2
RIOK3 RIO kinase 3
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SATB2 SATB homeobox 2
SERINC5 serine incorporator 5
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMIM7 small integral membrane protein 7
SNAI2 snail family zinc finger 2
SOX9 SRY (sex determining region Y)-box 9
SQSTM1 sequestosome 1
SRGN serglycin
STAR steroidogenic acute regulatory protein
STC1 stanniocalcin 1
STK38 serine/threonine kinase 38
STX1A syntaxin 1A (brain)
TBPL1 TBP-like 1
TBX3 T-box 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPM4 tropomyosin 4
TPST2 tyrosylprotein sulfotransferase 2
TRBC1 T cell receptor beta constant 1
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIB1 tribbles pseudokinase 1
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
TXNL4B thioredoxin-like 4B
TXNRD1 thioredoxin reductase 1
VEGFA vascular endothelial growth factor A
WNT5A wingless-type MMTV integration site family, member 5A
WNT5B wingless-type MMTV integration site family, member 5B
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)
ZFAND5 zinc finger, AN1-type domain 5
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ACAT1 acetyl-CoA acetyltransferase 1
AGR2 anterior gradient 2
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALCAM activated leukocyte cell adhesion molecule
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANXA7 annexin A7
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARMCX6 armadillo repeat containing, X-linked 6
ARMT1 acidic residue methyltransferase 1
B3GNT1
BAD BCL2-associated agonist of cell death
BCAS3 breast carcinoma amplified sequence 3
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIRC5 baculoviral IAP repeat containing 5
BST2 bone marrow stromal cell antigen 2
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C21ORF33 chromosome 21 open reading frame 33
C2CD5 C2 calcium-dependent domain containing 5
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CCND1 cyclin D1
CCNF cyclin F
CDC25B cell division cycle 25B
CDC42 cell division cycle 42
CDK1 cyclin-dependent kinase 1
CDK4 cyclin-dependent kinase 4
CENPA centromere protein A
CNOT7 CCR4-NOT transcription complex, subunit 7
COA3 cytochrome c oxidase assembly factor 3
COMMD4 COMM domain containing 4
CTSH cathepsin H
CYFIP2 cytoplasmic FMR1 interacting protein 2
DCK deoxycytidine kinase
DCXR dicarbonyl/L-xylulose reductase
DDB2 damage-specific DNA binding protein 2, 48kDa
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLD dihydrolipoamide dehydrogenase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DPYSL2 dihydropyrimidinase-like 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF5A eukaryotic translation initiation factor 5A
ELOVL6 ELOVL fatty acid elongase 6
ESR1 estrogen receptor 1
F12 coagulation factor XII (Hageman factor)
FAM63A family with sequence similarity 63, member A
FBP1 fructose-1,6-bisphosphatase 1
FKBP3 FK506 binding protein 3, 25kDa
FLNB filamin B, beta
GALE UDP-galactose-4-epimerase
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GAS1 growth arrest-specific 1
GATA3 GATA binding protein 3
GINS1 GINS complex subunit 1 (Psf1 homolog)
H1F0 H1 histone family, member 0
HADH hydroxyacyl-CoA dehydrogenase
HAUS4 HAUS augmin-like complex, subunit 4
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IGF1R insulin-like growth factor 1 receptor
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
IRAK1 interleukin-1 receptor-associated kinase 1
KDM5D lysine (K)-specific demethylase 5D
KIAA0391 KIAA0391
KRT7 keratin 7, type II
LAGE3 L antigen family, member 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIG1 ligase I, DNA, ATP-dependent
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LY6E lymphocyte antigen 6 complex, locus E
LYPLA1 lysophospholipase I
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MGST2 microsomal glutathione S-transferase 2
MLPH melanophilin
MRPL12 mitochondrial ribosomal protein L12
MRPL23 mitochondrial ribosomal protein L23
MRPS16 mitochondrial ribosomal protein S16
MRPS7 mitochondrial ribosomal protein S7
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MX2 MX dynamin-like GTPase 2
MYCBP MYC binding protein
MYH10 myosin, heavy chain 10, non-muscle
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NBN nibrin
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3
NDUFC1 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa
NFIB nuclear factor I/B
NHP2 NHP2 ribonucleoprotein
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NPDC1 neural proliferation, differentiation and control, 1
NPY1R neuropeptide Y receptor Y1
NRIP1 nuclear receptor interacting protein 1
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
NUP210 nucleoporin 210kDa
NUP37 nucleoporin 37kDa
OXLD1 oxidoreductase-like domain containing 1
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PAN2 PAN2 poly(A) specific ribonuclease subunit
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PFAS phosphoribosylformylglycinamidine synthase
PIP prolactin-induced protein
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PPA2 pyrophosphatase (inorganic) 2
PRDX3 peroxiredoxin 3
PRKCD protein kinase C, delta
PRSS23 protease, serine, 23
PSCA prostate stem cell antigen
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PXMP2 peroxisomal membrane protein 2, 22kDa
RAB4A RAB4A, member RAS oncogene family
RBM47 RNA binding motif protein 47
RFC2 replication factor C (activator 1) 2, 40kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RPA3 replication protein A3, 14kDa
RPS4Y1 ribosomal protein S4, Y-linked 1
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEPT9 septin 9
SEPW1 selenoprotein W, 1
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SNX17 sorting nexin 17
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPDEF SAM pointed domain containing ETS transcription factor
SREBF1 sterol regulatory element binding transcription factor 1
STRA13 stimulated by retinoic acid 13
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
SYNGR2 synaptogyrin 2
SYT1 synaptotagmin I
TBC1D16 TBC1 domain family, member 16
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM106C transmembrane protein 106C
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM1 tropomyosin 1 (alpha)
TRIM14 tripartite motif containing 14
TSPAN31 tetraspanin 31
TUSC3 tumor suppressor candidate 3
UBE2C ubiquitin-conjugating enzyme E2C
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X
WDR61 WD repeat domain 61
XBP1 X-box binding protein 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon