BRD-A43155244_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

204 genes differentially expressed following the BRD-A43155244_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
AMIGO2 adhesion molecule with Ig-like domain 2
APOC1 apolipoprotein C-I
ARID5B AT rich interactive domain 5B (MRF1-like)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BAMBI BMP and activin membrane-bound inhibitor
BLNK B-cell linker
BTG2 BTG family, member 2
BTG3 BTG family, member 3
C10ORF10 chromosome 10 open reading frame 10
C3 complement component 3
CA2 carbonic anhydrase II
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA1 cyclin A1
CCND2 cyclin D2
CCNG2 cyclin G2
CD200 CD200 molecule
CD8A CD8a molecule
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CP ceruloplasmin (ferroxidase)
CPE carboxypeptidase E
CPM carboxypeptidase M
CRABP1 cellular retinoic acid binding protein 1
CTH cystathionine gamma-lyase
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP6 dual specificity phosphatase 6
EGLN3 egl-9 family hypoxia-inducible factor 3
EGR1 early growth response 1
ENOPH1 enolase-phosphatase 1
EPAS1 endothelial PAS domain protein 1
ESR1 estrogen receptor 1
FAM69A family with sequence similarity 69, member A
FGL2 fibrinogen-like 2
FILIP1L filamin A interacting protein 1-like
FOS FBJ murine osteosarcoma viral oncogene homolog
FTH1 ferritin, heavy polypeptide 1
GADD45B growth arrest and DNA-damage-inducible, beta
GATA2 GATA binding protein 2
GNLY granulysin
GUSBP11 glucuronidase, beta pseudogene 11
H2BFS H2B histone family, member S (pseudogene)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HHEX hematopoietically expressed homeobox
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BG histone cluster 1, H2bg
HIST1H2BK histone cluster 1, H2bk
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMOX1 heme oxygenase 1
HOXD1 homeobox D1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
IER5 immediate early response 5
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IL1R1 interleukin 1 receptor, type I
INSIG1 insulin induced gene 1
ITM2A integral membrane protein 2A
JCHAIN joining chain of multimeric IgA and IgM
JUNB jun B proto-oncogene
KCTD14 potassium channel tetramerization domain containing 14
KIAA0226L KIAA0226-like
KRT23 keratin 23, type I
LCK LCK proto-oncogene, Src family tyrosine kinase
LGALS3 lectin, galactoside-binding, soluble, 3
LOC100505650 uncharacterized LOC100505650
LPAR6 lysophosphatidic acid receptor 6
LYZ lysozyme
MAN1A1 mannosidase, alpha, class 1A, member 1
MMP1 matrix metallopeptidase 1
MMP9 matrix metallopeptidase 9
NR4A2 nuclear receptor subfamily 4, group A, member 2
ODC1 ornithine decarboxylase 1
OSR2 odd-skipped related transciption factor 2
PARP8 poly (ADP-ribose) polymerase family, member 8
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEG3 paternally expressed 3
PERP PERP, TP53 apoptosis effector
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POU2AF1 POU class 2 associating factor 1
RGCC regulator of cell cycle
RGS10 regulator of G-protein signaling 10
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
S100A8 S100 calcium binding protein A8
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SHB Src homology 2 domain containing adaptor protein B
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SPARCL1 SPARC-like 1 (hevin)
TFRC transferrin receptor
TMEM30B transmembrane protein 30B
TRBC1 T cell receptor beta constant 1
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIB1 tribbles pseudokinase 1
TRIM36 tripartite motif containing 36
TSPAN7 tetraspanin 7
TWF1 twinfilin actin binding protein 1
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VEGFA vascular endothelial growth factor A
VSNL1 visinin-like 1
WARS tryptophanyl-tRNA synthetase
XCL1 chemokine (C motif) ligand 1
XIST X inactive specific transcript (non-protein coding)
ZBED2 zinc finger, BED-type containing 2
ZFP36 ZFP36 ring finger protein
ZNF331 zinc finger protein 331
ZNF544 zinc finger protein 544
ZNF586 zinc finger protein 586
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALCAM activated leukocyte cell adhesion molecule
ANXA6 annexin A6
AREG amphiregulin
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIN1 bridging integrator 1
BST2 bone marrow stromal cell antigen 2
CBR3 carbonyl reductase 3
CCNF cyclin F
CD59 CD59 molecule, complement regulatory protein
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CHSY1 chondroitin sulfate synthase 1
CLIP2 CAP-GLY domain containing linker protein 2
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYTH1 cytohesin 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DMBT1 deleted in malignant brain tumors 1
EMP3 epithelial membrane protein 3
FLNA filamin A, alpha
FOLR1 folate receptor 1 (adult)
GSTP1 glutathione S-transferase pi 1
HOXA10 homeobox A10
HOXC10 homeobox C10
HOXC6 homeobox C6
IGF1R insulin-like growth factor 1 receptor
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
JADE2 jade family PHD finger 2
KANK2 KN motif and ankyrin repeat domains 2
KIAA0100 KIAA0100
KIAA0368 KIAA0368
LAGE3 L antigen family, member 3
LAMC1 laminin, gamma 1 (formerly LAMB2)
LOX lysyl oxidase
LTBP3 latent transforming growth factor beta binding protein 3
MACF1 microtubule-actin crosslinking factor 1
MAGED1 melanoma antigen family D1
MAP1B microtubule-associated protein 1B
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MARCKS myristoylated alanine-rich protein kinase C substrate
MSRB2 methionine sulfoxide reductase B2
NOTCH2 notch 2
NUP62 nucleoporin 62kDa
OXTR oxytocin receptor
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PRKCA protein kinase C, alpha
PTGES prostaglandin E synthase
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RHOBTB3 Rho-related BTB domain containing 3
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLIT2 slit homolog 2 (Drosophila)
SMAD3 SMAD family member 3
SORBS3 sorbin and SH3 domain containing 3
SPRR1A small proline-rich protein 1A
STXBP1 syntaxin binding protein 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TATDN2 TatD DNase domain containing 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TTC3 tetratricopeptide repeat domain 3
ZBTB18 zinc finger and BTB domain containing 18
ZBTB20 zinc finger and BTB domain containing 20
ZCCHC24 zinc finger, CCHC domain containing 24