BRD-A43126523_NCGC00183690-01_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

215 genes differentially expressed following the BRD-A43126523_NCGC00183690-01_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACADVL acyl-CoA dehydrogenase, very long chain
ALDOC aldolase C, fructose-bisphosphate
APLP2 amyloid beta (A4) precursor-like protein 2
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C3ORF14 chromosome 3 open reading frame 14
CA2 carbonic anhydrase II
CCDC28A coiled-coil domain containing 28A
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CERS6 ceramide synthase 6
CHIC2 cysteine-rich hydrophobic domain 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL5A2 collagen, type V, alpha 2
CPE carboxypeptidase E
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUOX2 dual oxidase 2
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EMX2 empty spiracles homeobox 2
ENO2 enolase 2 (gamma, neuronal)
ERGIC3 ERGIC and golgi 3
ERO1L ERO1-like (S. cerevisiae)
FAM189A2 family with sequence similarity 189, member A2
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FOXN3 forkhead box N3
GALC galactosylceramidase
GDF15 growth differentiation factor 15
GGT1 gamma-glutamyltransferase 1
GLB1L2 galactosidase, beta 1-like 2
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GPI glucose-6-phosphate isomerase
GREM1 gremlin 1, DAN family BMP antagonist
GSDMB gasdermin B
H1F0 H1 histone family, member 0
HECA headcase homolog (Drosophila)
HK2 hexokinase 2
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGXB4 HMG box domain containing 4
INHBA inhibin, beta A
INSR insulin receptor
IRS2 insulin receptor substrate 2
KDM3A lysine (K)-specific demethylase 3A
LGALS8 lectin, galactoside-binding, soluble, 8
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP9 microtubule-associated protein 9
MFAP5 microfibrillar associated protein 5
MMP12 matrix metallopeptidase 12
MXI1 MAX interactor 1, dimerization protein
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle
NDRG1 N-myc downstream regulated 1
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NPC1 Niemann-Pick disease, type C1
NRN1 neuritin 1
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM4 olfactomedin 4
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAN2 PAN2 poly(A) specific ribonuclease subunit
PELI1 pellino E3 ubiquitin protein ligase 1
PGM1 phosphoglucomutase 1
PLA2G16 phospholipase A2, group XVI
PLCB4 phospholipase C, beta 4
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POMZP3 POM121 and ZP3 fusion
PSAP prosaposin
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RAB11FIP2 RAB11 family interacting protein 2 (class I)
RBM6 RNA binding motif protein 6
RGL2 ral guanine nucleotide dissociation stimulator-like 2
RIOK3 RIO kinase 3
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RRAGD Ras-related GTP binding D
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC22A18 solute carrier family 22, member 18
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPAG4 sperm associated antigen 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPRY2 sprouty homolog 2 (Drosophila)
STC1 stanniocalcin 1
SULF1 sulfatase 1
TMC5 transmembrane channel-like 5
TMEM47 transmembrane protein 47
TNS1 tensin 1
TUFT1 tuftelin 1
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor
WDTC1 WD and tetratricopeptide repeats 1
WFS1 Wolfram syndrome 1 (wolframin)
ZDHHC11 zinc finger, DHHC-type containing 11

decreased expression

Symbol Name
ACOT9 acyl-CoA thioesterase 9
ADGRE5 adhesion G protein-coupled receptor E5
AMD1 adenosylmethionine decarboxylase 1
AMDHD2 amidohydrolase domain containing 2
ASF1A anti-silencing function 1A histone chaperone
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BMI1 BMI1 proto-oncogene, polycomb ring finger
BST2 bone marrow stromal cell antigen 2
C6ORF62 chromosome 6 open reading frame 62
CCL2 chemokine (C-C motif) ligand 2
CCND1 cyclin D1
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CDC20 cell division cycle 20
CDC42SE1 CDC42 small effector 1
CDCA3 cell division cycle associated 3
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CENPA centromere protein A
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CKS2 CDC28 protein kinase regulatory subunit 2
COL6A1 collagen, type VI, alpha 1
COLEC12 collectin sub-family member 12
COMMD3 COMM domain containing 3
DCTPP1 dCTP pyrophosphatase 1
DKC1 dyskeratosis congenita 1, dyskerin
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EIF4A1 eukaryotic translation initiation factor 4A1
EIF5 eukaryotic translation initiation factor 5
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP3 epithelial membrane protein 3
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FBLN1 fibulin 1
FRZB frizzled-related protein
FSCN1 fascin actin-bundling protein 1
GAL galanin/GMAP prepropeptide
GCLM glutamate-cysteine ligase, modifier subunit
GLIPR1 GLI pathogenesis-related 1
GPX3 glutathione peroxidase 3
HMMR hyaluronan-mediated motility receptor (RHAMM)
HMOX1 heme oxygenase 1
HN1 hematological and neurological expressed 1
HOPX HOP homeobox
HOXA10 homeobox A10
HOXA5 homeobox A5
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
JADE2 jade family PHD finger 2
KIAA0125 KIAA0125
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT10 keratin 10, type I
LAMB1 laminin, beta 1
LAPTM4B lysosomal protein transmembrane 4 beta
LBR lamin B receptor
LPAR1 lysophosphatidic acid receptor 1
LRRC17 leucine rich repeat containing 17
MARCKS myristoylated alanine-rich protein kinase C substrate
MAT2A methionine adenosyltransferase II, alpha
MTSS1 metastasis suppressor 1
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NOP16 NOP16 nucleolar protein
PBK PDZ binding kinase
PDGFA platelet-derived growth factor alpha polypeptide
PITX1 paired-like homeodomain 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLK1 polo-like kinase 1
PMM2 phosphomannomutase 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIF peptidylprolyl isomerase F
PRDX4 peroxiredoxin 4
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RPL27A ribosomal protein L27a
RPL38 ribosomal protein L38
RPP40 ribonuclease P/MRP 40kDa subunit
RPS11 ribosomal protein S11
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUVBL1 RuvB-like AAA ATPase 1
S100A2 S100 calcium binding protein A2
SDF2L1 stromal cell-derived factor 2-like 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SFN stratifin
SFPQ splicing factor proline/glutamine-rich
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SOX4 SRY (sex determining region Y)-box 4
SPON1 spondin 1, extracellular matrix protein
SQLE squalene epoxidase
SRGN serglycin
SRSF1 serine/arginine-rich splicing factor 1
SRSF2 serine/arginine-rich splicing factor 2
SRSF3 serine/arginine-rich splicing factor 3
SRSF7 serine/arginine-rich splicing factor 7
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TCF4 transcription factor 4
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TM4SF1 transmembrane 4 L six family member 1
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TRA2B transformer 2 beta homolog (Drosophila)
TUBB tubulin, beta class I
VAMP8 vesicle-associated membrane protein 8
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZMIZ1 zinc finger, MIZ-type containing 1