BRD-A42649439_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

201 genes differentially expressed following the BRD-A42649439_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AMIGO2 adhesion molecule with Ig-like domain 2
APOD apolipoprotein D
AREG amphiregulin
BASP1 brain abundant, membrane attached signal protein 1
BCAS1 breast carcinoma amplified sequence 1
BHLHE41 basic helix-loop-helix family, member e41
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C1ORF106 chromosome 1 open reading frame 106
CALML5 calmodulin-like 5
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPN2 calpain 2, (m/II) large subunit
CCNG2 cyclin G2
CD59 CD59 molecule, complement regulatory protein
CEMIP cell migration inducing protein, hyaluronan binding
CLDN3 claudin 3
CLDN4 claudin 4
CLTB clathrin, light chain B
CST1 cystatin SN
DRAM1 DNA-damage regulated autophagy modulator 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EFNA1 ephrin-A1
EGR1 early growth response 1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ERBB3 erb-b2 receptor tyrosine kinase 3
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM60A family with sequence similarity 60, member A
FBLN1 fibulin 1
FOSL1 FOS-like antigen 1
GBP2 guanylate binding protein 2, interferon-inducible
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRB7 growth factor receptor-bound protein 7
HBP1 HMG-box transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST2H2BE histone cluster 2, H2be
HIST3H2A histone cluster 3, H2a
ICAM1 intercellular adhesion molecule 1
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IL32 interleukin 32
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
ITGB4 integrin, beta 4
JUNB jun B proto-oncogene
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KDM3A lysine (K)-specific demethylase 3A
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KRT18 keratin 18, type I
KRT23 keratin 23, type I
KRT7 keratin 7, type II
KYNU kynureninase
LBH limb bud and heart development
LRP10 low density lipoprotein receptor-related protein 10
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAOA monoamine oxidase A
MARCKS myristoylated alanine-rich protein kinase C substrate
MGLL monoglyceride lipase
MMP12 matrix metallopeptidase 12
MMP7 matrix metallopeptidase 7
MVP major vault protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NT5E 5'-nucleotidase, ecto (CD73)
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OPTN optineurin
PAWR PRKC, apoptosis, WT1, regulator
PDLIM1 PDZ and LIM domain 1
PDLIM5 PDZ and LIM domain 5
PERP PERP, TP53 apoptosis effector
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLIN2 perilipin 2
PLSCR3 phospholipid scramblase 3
PNMA2 paraneoplastic Ma antigen 2
PTGIS prostaglandin I2 (prostacyclin) synthase
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB9A RAB9A, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIN2 Ras and Rab interactor 2
RNASET2 ribonuclease T2
RNF19B ring finger protein 19B
RNF44 ring finger protein 44
RTN2 reticulon 2
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCCPDH saccharopine dehydrogenase (putative)
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SIK1 salt-inducible kinase 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SMAD3 SMAD family member 3
SOX4 SRY (sex determining region Y)-box 4
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SQSTM1 sequestosome 1
SULF1 sulfatase 1
TIMP1 TIMP metallopeptidase inhibitor 1
TM4SF1 transmembrane 4 L six family member 1
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNIP1 TNFAIP3 interacting protein 1
TSKU tsukushi, small leucine rich proteoglycan
VCL vinculin
YBX3 Y box binding protein 3
YPEL5 yippee-like 5 (Drosophila)
ZC3H12A zinc finger CCCH-type containing 12A

decreased expression

Symbol Name
ACACB acetyl-CoA carboxylase beta
ATAD2 ATPase family, AAA domain containing 2
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPE centromere protein E, 312kDa
CENPN centromere protein N
CEP55 centrosomal protein 55kDa
CPE carboxypeptidase E
DCP2 decapping mRNA 2
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
FAM111A family with sequence similarity 111, member A
FANCI Fanconi anemia, complementation group I
FOXM1 forkhead box M1
G0S2 G0/G1 switch 2
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GTSE1 G-2 and S-phase expressed 1
H2AFV H2A histone family, member V
H2AFX H2A histone family, member X
HADH hydroxyacyl-CoA dehydrogenase
HJURP Holliday junction recognition protein
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
KIF4A kinesin family member 4A
MCM10 minichromosome maintenance complex component 10
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MPC1 mitochondrial pyruvate carrier 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG non-SMC condensin I complex, subunit G
NCAPH non-SMC condensin I complex, subunit H
NEK2 NIMA-related kinase 2
NUSAP1 nucleolar and spindle associated protein 1
ORC6 origin recognition complex, subunit 6
PBK PDZ binding kinase
PHGDH phosphoglycerate dehydrogenase
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLK1 polo-like kinase 1
PNN pinin, desmosome associated protein
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRC1 protein regulator of cytokinesis 1
PSRC1 proline/serine-rich coiled-coil 1
PTTG1 pituitary tumor-transforming 1
REG1A regenerating islet-derived 1 alpha
SHCBP1 SHC SH2-domain binding protein 1
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPAG5 sperm associated antigen 5
SPDL1 spindle apparatus coiled-coil protein 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TFDP1 transcription factor Dp-1
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
UBE2C ubiquitin-conjugating enzyme E2C
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
VTCN1 V-set domain containing T cell activation inhibitor 1
ZWILCH zwilch kinetochore protein
ZWINT ZW10 interacting kinetochore protein