BRD-A42649439_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

104 genes differentially expressed following the BRD-A42649439_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGO2 argonaute RISC catalytic component 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANKRD12 ankyrin repeat domain 12
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BTG1 B-cell translocation gene 1, anti-proliferative
CCL20 chemokine (C-C motif) ligand 20
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHIC2 cysteine-rich hydrophobic domain 2
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DUSP6 dual specificity phosphatase 6
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR1 early growth response 1
EGR3 early growth response 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
F2RL1 coagulation factor II (thrombin) receptor-like 1
FASTKD5 FAST kinase domains 5
FNDC3B fibronectin type III domain containing 3B
FOSL1 FOS-like antigen 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
IER3 immediate early response 3
KDM5D lysine (K)-specific demethylase 5D
KLF6 Kruppel-like factor 6
KRT6B keratin 6B, type II
LDLR low density lipoprotein receptor
LGALS8 lectin, galactoside-binding, soluble, 8
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K3 mitogen-activated protein kinase kinase 3
MCL1 myeloid cell leukemia 1
MKNK1 MAP kinase interacting serine/threonine kinase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
PI3 peptidase inhibitor 3, skin-derived
PLAUR plasminogen activator, urokinase receptor
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTX3 pentraxin 3, long
S100A6 S100 calcium binding protein A6
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPRR1B small proline-rich protein 1B
SPRR2B small proline-rich protein 2B
STC2 stanniocalcin 2
TFF3 trefoil factor 3 (intestinal)
THBS1 thrombospondin 1
TXNRD1 thioredoxin reductase 1
UGCG UDP-glucose ceramide glucosyltransferase
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
ADAM10 ADAM metallopeptidase domain 10
ADD3 adducin 3 (gamma)
ADIRF adipogenesis regulatory factor
CBR4 carbonyl reductase 4
CCND2 cyclin D2
CD38 CD38 molecule
CEP70 centrosomal protein 70kDa
CLIC4 chloride intracellular channel 4
CLU clusterin
CPE carboxypeptidase E
FGFR3 fibroblast growth factor receptor 3
FGFR4 fibroblast growth factor receptor 4
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GGCT gamma-glutamylcyclotransferase
GM2A GM2 ganglioside activator
GNAS GNAS complex locus
HBB hemoglobin, beta
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
LGALS1 lectin, galactoside-binding, soluble, 1
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LMO2 LIM domain only 2 (rhombotin-like 1)
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP7 microtubule-associated protein 7
MEF2C myocyte enhancer factor 2C
MFAP5 microfibrillar associated protein 5
PEG3 paternally expressed 3
PHYH phytanoyl-CoA 2-hydroxylase
PODXL podocalyxin-like
PRKCB protein kinase C, beta
QPRT quinolinate phosphoribosyltransferase
RAD51C RAD51 paralog C
REEP1 receptor accessory protein 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TSPYL5 TSPY-like 5
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
XIST X inactive specific transcript (non-protein coding)