BRD-A41692738_TGX-221_MDAMB231_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

85 genes differentially expressed following the BRD-A41692738_TGX-221_MDAMB231_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADD3 adducin 3 (gamma)
ANKRD10 ankyrin repeat domain 10
ATMIN ATM interactor
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEMIP cell migration inducing protein, hyaluronan binding
CLU clusterin
CSRP2 cysteine and glycine-rich protein 2
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DAPK1 death-associated protein kinase 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSP desmoplakin
KRCC1 lysine-rich coiled-coil 1
MTUS1 microtubule associated tumor suppressor 1
MXI1 MAX interactor 1, dimerization protein
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PRAME preferentially expressed antigen in melanoma
RGS5 regulator of G-protein signaling 5
RPS4Y1 ribosomal protein S4, Y-linked 1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
TCAF1 TRPM8 channel-associated factor 1
TCF4 transcription factor 4
TRAPPC6A trafficking protein particle complex 6A
UGDH UDP-glucose 6-dehydrogenase
ZC3HAV1 zinc finger CCCH-type, antiviral 1

decreased expression

Symbol Name
ADGRL2 adhesion G protein-coupled receptor L2
ADORA2B adenosine A2b receptor
ADRB2 adrenoceptor beta 2, surface
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AP2B1 adaptor-related protein complex 2, beta 1 subunit
AREG amphiregulin
BEX1 brain expressed, X-linked 1
CCL20 chemokine (C-C motif) ligand 20
CCND1 cyclin D1
CDC25A cell division cycle 25A
COL3A1 collagen, type III, alpha 1
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR2 early growth response 2
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EREG epiregulin
FJX1 four jointed box 1 (Drosophila)
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GPRC5A G protein-coupled receptor, class C, group 5, member A
HBEGF heparin-binding EGF-like growth factor
HDAC9 histone deacetylase 9
HMGA2 high mobility group AT-hook 2
HOPX HOP homeobox
IER3 immediate early response 3
KLF6 Kruppel-like factor 6
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MCL1 myeloid cell leukemia 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NOTCH2 notch 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAUR plasminogen activator, urokinase receptor
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC25A24 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
SOX11 SRY (sex determining region Y)-box 11
SPRY2 sprouty homolog 2 (Drosophila)
STEAP1 six transmembrane epithelial antigen of the prostate 1
STX1A syntaxin 1A (brain)
TFF1 trefoil factor 1
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TUBB2A tubulin, beta 2A class IIa
VCAN versican
VCL vinculin
XIST X inactive specific transcript (non-protein coding)