BRD-A41692738_TGX-221_MCF10A_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

134 genes differentially expressed following the BRD-A41692738_TGX-221_MCF10A_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C3 aldo-keto reductase family 1, member C3
APOD apolipoprotein D
ARMT1 acidic residue methyltransferase 1
C10ORF10 chromosome 10 open reading frame 10
CA12 carbonic anhydrase XII
CSRP2 cysteine and glycine-rich protein 2
CXCL12 chemokine (C-X-C motif) ligand 12
CYB5A cytochrome b5 type A (microsomal)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFHD1 EF-hand domain family, member D1
FADS1 fatty acid desaturase 1
FBLN1 fibulin 1
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GPM6B glycoprotein M6B
HILPDA hypoxia inducible lipid droplet-associated
HIST1H1C histone cluster 1, H1c
HSPA2 heat shock 70kDa protein 2
HSPA4L heat shock 70kDa protein 4-like
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGFBP5 insulin-like growth factor binding protein 5
ITFG1 integrin alpha FG-GAP repeat containing 1
LTBP1 latent transforming growth factor beta binding protein 1
MAN1A1 mannosidase, alpha, class 1A, member 1
OSBPL9 oxysterol binding protein-like 9
OSR2 odd-skipped related transciption factor 2
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
SAP30 Sin3A-associated protein, 30kDa
SEPP1 selenoprotein P, plasma, 1
SMAD1 SMAD family member 1
SMC2 structural maintenance of chromosomes 2
SOD2 superoxide dismutase 2, mitochondrial
STC2 stanniocalcin 2
STOM stomatin
SYBU syntabulin (syntaxin-interacting)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSC22D3 TSC22 domain family, member 3
VAV3 vav 3 guanine nucleotide exchange factor

decreased expression

Symbol Name
ADAM28 ADAM metallopeptidase domain 28
AIM2 absent in melanoma 2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
BASP1 brain abundant, membrane attached signal protein 1
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BHLHE40 basic helix-loop-helix family, member e40
CALR calreticulin
CCND1 cyclin D1
CCR7 chemokine (C-C motif) receptor 7
CD24 CD24 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CHGB chromogranin B
CLC Charcot-Leyden crystal galectin
COTL1 coactosin-like F-actin binding protein 1
CSNK1E casein kinase 1, epsilon
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP2 dual specificity phosphatase 2
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EFHD2 EF-hand domain family, member D2
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EPHA2 EPH receptor A2
EREG epiregulin
F3 coagulation factor III (thromboplastin, tissue factor)
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GAL galanin/GMAP prepropeptide
HBEGF heparin-binding EGF-like growth factor
HMGA2 high mobility group AT-hook 2
IER2 immediate early response 2
IER3 immediate early response 3
IGFBP7 insulin-like growth factor binding protein 7
IL1B interleukin 1, beta
KCTD12 potassium channel tetramerization domain containing 12
KLF10 Kruppel-like factor 10
KRT18 keratin 18, type I
KRT23 keratin 23, type I
LIF leukemia inhibitory factor
LOC100505650 uncharacterized LOC100505650
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTF lactotransferrin
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K3 mitogen-activated protein kinase kinase 3
MAP7 microtubule-associated protein 7
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MSLN mesothelin
MYC v-myc avian myelocytomatosis viral oncogene homolog
ODC1 ornithine decarboxylase 1
PCSK1 proprotein convertase subtilisin/kexin type 1
PDLIM4 PDZ and LIM domain 4
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAUR plasminogen activator, urokinase receptor
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PODXL podocalyxin-like
POSTN periostin, osteoblast specific factor
PTRF polymerase I and transcript release factor
RNASE3 ribonuclease, RNase A family, 3
SATB1 SATB homeobox 1
SCGB2A1 secretoglobin, family 2A, member 1
SDC4 syndecan 4
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFRP1 secreted frizzled-related protein 1
SNAP25 synaptosomal-associated protein, 25kDa
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SST somatostatin
STX1A syntaxin 1A (brain)
TACSTD2 tumor-associated calcium signal transducer 2
TES testin LIM domain protein
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNC tenascin C
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TUBB6 tubulin, beta 6 class V
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
VIM vimentin
WWTR1 WW domain containing transcription regulator 1