BRD-A41250203_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

206 genes differentially expressed following the BRD-A41250203_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD3 abhydrolase domain containing 3
ADM adrenomedullin
ANKRD10 ankyrin repeat domain 10
ANKRD12 ankyrin repeat domain 12
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARC activity-regulated cytoskeleton-associated protein
ARID4B AT rich interactive domain 4B (RBP1-like)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
BTG2 BTG family, member 2
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CALML5 calmodulin-like 5
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLC Charcot-Leyden crystal galectin
CLU clusterin
COL6A1 collagen, type VI, alpha 1
CREB3L2 cAMP responsive element binding protein 3-like 2
CTH cystathionine gamma-lyase
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DLK1 delta-like 1 homolog (Drosophila)
DMD dystrophin
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPAS1 endothelial PAS domain protein 1
FCGBP Fc fragment of IgG binding protein
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATA2 GATA binding protein 2
GEM GTP binding protein overexpressed in skeletal muscle
GSE1 Gse1 coiled-coil protein
GUSBP11 glucuronidase, beta pseudogene 11
H2BFS H2B histone family, member S (pseudogene)
HBD hemoglobin, delta
HEPH hephaestin
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIC2 hypermethylated in cancer 2
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BI histone cluster 1, H2bi
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HLA-E major histocompatibility complex, class I, E
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGFBP5 insulin-like growth factor binding protein 5
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
INHBE inhibin, beta E
ISLR immunoglobulin superfamily containing leucine-rich repeat
ITM2A integral membrane protein 2A
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KCTD5 potassium channel tetramerization domain containing 5
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KRT23 keratin 23, type I
LMO4 LIM domain only 4
LY96 lymphocyte antigen 96
MAN1A1 mannosidase, alpha, class 1A, member 1
MEG3 maternally expressed 3 (non-protein coding)
MMP11 matrix metallopeptidase 11
MS4A12 membrane-spanning 4-domains, subfamily A, member 12
MT1M metallothionein 1M
MUC16 mucin 16, cell surface associated
MUC5B mucin 5B, oligomeric mucus/gel-forming
MZB1 marginal zone B and B1 cell-specific protein
NFIL3 nuclear factor, interleukin 3 regulated
NRCAM neuronal cell adhesion molecule
NT5E 5'-nucleotidase, ecto (CD73)
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POU2AF1 POU class 2 associating factor 1
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCN3A sodium channel, voltage gated, type III alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SOD2 superoxide dismutase 2, mitochondrial
SPARCL1 SPARC-like 1 (hevin)
SRGN serglycin
STMN2 stathmin 2
TCF4 transcription factor 4
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM255A transmembrane protein 255A
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRBC1 T cell receptor beta constant 1
TSPAN7 tetraspanin 7
TXNIP thioredoxin interacting protein
TXNL4B thioredoxin-like 4B
UGDH UDP-glucose 6-dehydrogenase
VTCN1 V-set domain containing T cell activation inhibitor 1
XBP1 X-box binding protein 1
YPEL5 yippee-like 5 (Drosophila)
ZC3HAV1 zinc finger CCCH-type, antiviral 1
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZG16 zymogen granule protein 16
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ACP6 acid phosphatase 6, lysophosphatidic
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADRB2 adrenoceptor beta 2, surface
AKR1C3 aldo-keto reductase family 1, member C3
AREG amphiregulin
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASPH aspartate beta-hydroxylase
B3GNT1
BHLHE41 basic helix-loop-helix family, member e41
CCDC85B coiled-coil domain containing 85B
CCNA2 cyclin A2
CCND1 cyclin D1
CCNF cyclin F
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CDC25B cell division cycle 25B
CDCA4 cell division cycle associated 4
CNPY2 canopy FGF signaling regulator 2
CTBP2 C-terminal binding protein 2
EMG1 EMG1 N1-specific pseudouridine methyltransferase
EREG epiregulin
EXOSC4 exosome component 4
FEN1 flap structure-specific endonuclease 1
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11
GPC4 glypican 4
GRWD1 glutamate-rich WD repeat containing 1
HOXA10 homeobox A10
IGF1R insulin-like growth factor 1 receptor
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
KLHL9 kelch-like family member 9
KRT17 keratin 17, type I
KRT18 keratin 18, type I
LAMB3 laminin, beta 3
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAGEA3 melanoma antigen family A3
MARCKS myristoylated alanine-rich protein kinase C substrate
MRPL12 mitochondrial ribosomal protein L12
NFIB nuclear factor I/B
NREP neuronal regeneration related protein
PKP4 plakophilin 4
PPARG peroxisome proliferator-activated receptor gamma
PRSS23 protease, serine, 23
RANBP6 RAN binding protein 6
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RPP25 ribonuclease P/MRP 25kDa subunit
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAGA Ras-related GTP binding A
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
SCAND1 SCAN domain containing 1
SMAD3 SMAD family member 3
SRSF11 serine/arginine-rich splicing factor 11
TBC1D16 TBC1 domain family, member 16
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TM4SF1 transmembrane 4 L six family member 1
TMEM185B transmembrane protein 185B
TMEM223 transmembrane protein 223
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN8 tetraspanin 8
TXNDC9 thioredoxin domain containing 9
UBE2E3 ubiquitin-conjugating enzyme E2E 3
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon