BRD-A40431293_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

140 genes differentially expressed following the BRD-A40431293_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ARG2 arginase 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATF3 activating transcription factor 3
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
BCL6 B-cell CLL/lymphoma 6
BTG1 B-cell translocation gene 1, anti-proliferative
BTG3 BTG family, member 3
CADM1 cell adhesion molecule 1
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHIC2 cysteine-rich hydrophobic domain 2
CHMP1B charged multivesicular body protein 1B
CRABP1 cellular retinoic acid binding protein 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSRP2 cysteine and glycine-rich protein 2
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CYB5R1 cytochrome b5 reductase 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DHCR7 7-dehydrocholesterol reductase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FOXO3 forkhead box O3
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GTF2B general transcription factor IIB
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBP1 HMG-box transcription factor 1
HECA headcase homolog (Drosophila)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IFRD1 interferon-related developmental regulator 1
IRS2 insulin receptor substrate 2
JMJD1C jumonji domain containing 1C
KLF4 Kruppel-like factor 4 (gut)
KLHL24 kelch-like family member 24
LDLR low density lipoprotein receptor
LIMCH1 LIM and calponin homology domains 1
LXN latexin
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN2A1 mannosidase, alpha, class 2A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MT1M metallothionein 1M
NFIL3 nuclear factor, interleukin 3 regulated
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
OGFRL1 opioid growth factor receptor-like 1
PDLIM5 PDZ and LIM domain 5
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRAME preferentially expressed antigen in melanoma
QKI QKI, KH domain containing, RNA binding
RND3 Rho family GTPase 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SERTAD2 SERTA domain containing 2
SFRP1 secreted frizzled-related protein 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
TBC1D15 TBC1 domain family, member 15
TBPL1 TBP-like 1
TBX3 T-box 3
TGIF1 TGFB-induced factor homeobox 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM87A transmembrane protein 87A
TPD52L1 tumor protein D52-like 1
TXNIP thioredoxin interacting protein
WBP5 WW domain binding protein 5
ZBTB16 zinc finger and BTB domain containing 16

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHCY adenosylhomocysteinase
ANKRD36B ankyrin repeat domain 36B
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ATP5D ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
C1QBP complement component 1, q subcomponent binding protein
CA12 carbonic anhydrase XII
CBR4 carbonyl reductase 4
CCL20 chemokine (C-C motif) ligand 20
CFB complement factor B
CIAPIN1 cytokine induced apoptosis inhibitor 1
COL1A2 collagen, type I, alpha 2
CP ceruloplasmin (ferroxidase)
CSK c-src tyrosine kinase
EIF1AX eukaryotic translation initiation factor 1A, X-linked
ERBB2 erb-b2 receptor tyrosine kinase 2
FHL1 four and a half LIM domains 1
FLG filaggrin
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GGCT gamma-glutamylcyclotransferase
GJA1 gap junction protein, alpha 1, 43kDa
GOLGA8B golgin A8 family, member B
GPX1 glutathione peroxidase 1
HOPX HOP homeobox
IL13RA2 interleukin 13 receptor, alpha 2
KANK1 KN motif and ankyrin repeat domains 1
KRT1 keratin 1, type II
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LYPLA1 lysophospholipase I
MARCKS myristoylated alanine-rich protein kinase C substrate
METRN meteorin, glial cell differentiation regulator
MMD monocyte to macrophage differentiation-associated
ORM1 orosomucoid 1
PNMA2 paraneoplastic Ma antigen 2
RAP2C RAP2C, member of RAS oncogene family
RBP4 retinol binding protein 4, plasma
RHOBTB3 Rho-related BTB domain containing 3
RRP1B ribosomal RNA processing 1B
S100A7 S100 calcium binding protein A7
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TCTN1 tectonic family member 1
TF transferrin
TFPI2 tissue factor pathway inhibitor 2
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TMEM45A transmembrane protein 45A
TSEN2 TSEN2 tRNA splicing endonuclease subunit
UBE3C ubiquitin protein ligase E3C