BRD-A40431293_-666_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

162 genes differentially expressed following the BRD-A40431293_-666_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
ALCAM activated leukocyte cell adhesion molecule
ANPEP alanyl (membrane) aminopeptidase
ARG2 arginase 2
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAG3 BCL2-associated athanogene 3
BCL2L13 BCL2-like 13 (apoptosis facilitator)
BCL6 B-cell CLL/lymphoma 6
BEX4 brain expressed, X-linked 4
BTG1 B-cell translocation gene 1, anti-proliferative
BTG3 BTG family, member 3
C10ORF10 chromosome 10 open reading frame 10
CADM1 cell adhesion molecule 1
CD2AP CD2-associated protein
CD52 CD52 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLC Charcot-Leyden crystal galectin
CLGN calmegin
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
COL6A2 collagen, type VI, alpha 2
COL8A2 collagen, type VIII, alpha 2
COMP cartilage oligomeric matrix protein
CPE carboxypeptidase E
CRELD2 cysteine-rich with EGF-like domains 2
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTSK cathepsin K
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EPAS1 endothelial PAS domain protein 1
G0S2 G0/G1 switch 2
GAB2 GRB2-associated binding protein 2
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GABPB1 GA binding protein transcription factor, beta subunit 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GAGE3 G antigen 3
GAS6 growth arrest-specific 6
GPM6B glycoprotein M6B
HEPH hephaestin
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BG histone cluster 1, H2bg
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
INHBA inhibin, beta A
IPO13 importin 13
ISG20 interferon stimulated exonuclease gene 20kDa
JCHAIN joining chain of multimeric IgA and IgM
KLK5 kallikrein-related peptidase 5
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MAN1A1 mannosidase, alpha, class 1A, member 1
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MME membrane metallo-endopeptidase
MMP1 matrix metallopeptidase 1
MMP11 matrix metallopeptidase 11
MMP3 matrix metallopeptidase 3
MPO myeloperoxidase
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1M metallothionein 1M
MT1X metallothionein 1X
NCF2 neutrophil cytosolic factor 2
NFIL3 nuclear factor, interleukin 3 regulated
OLFM4 olfactomedin 4
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDE2A phosphodiesterase 2A, cGMP-stimulated
PELI1 pellino E3 ubiquitin protein ligase 1
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PSAT1 phosphoserine aminotransferase 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RBM7 RNA binding motif protein 7
SAT1 spermidine/spermine N1-acetyltransferase 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPATS2L spermatogenesis associated, serine-rich 2-like
SPINK1 serine peptidase inhibitor, Kazal type 1
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
TSC22D3 TSC22 domain family, member 3
TSPYL5 TSPY-like 5
UBXN4 UBX domain protein 4
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
XBP1 X-box binding protein 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AGR2 anterior gradient 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ASPH aspartate beta-hydroxylase
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CCNF cyclin F
CTSC cathepsin C
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DPH2 DPH2 homolog (S. cerevisiae)
GNAS GNAS complex locus
GPX3 glutathione peroxidase 3
GRWD1 glutamate-rich WD repeat containing 1
HN1 hematological and neurological expressed 1
IGFBP4 insulin-like growth factor binding protein 4
KIF20A kinesin family member 20A
LAMB1 laminin, beta 1
LAMC1 laminin, gamma 1 (formerly LAMB2)
MYD88 myeloid differentiation primary response 88
NFIB nuclear factor I/B
NUP62 nucleoporin 62kDa
PGD phosphogluconate dehydrogenase
PGM1 phosphoglucomutase 1
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PITX1 paired-like homeodomain 1
PLK1 polo-like kinase 1
PRSS23 protease, serine, 23
PXMP2 peroxisomal membrane protein 2, 22kDa
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBP1 retinol binding protein 1, cellular
RFC2 replication factor C (activator 1) 2, 40kDa
RHOBTB3 Rho-related BTB domain containing 3
SCEL sciellin
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SMAD3 SMAD family member 3
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SOX11 SRY (sex determining region Y)-box 11
SPRR1B small proline-rich protein 1B
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TGM2 transglutaminase 2
THSD7A thrombospondin, type I, domain containing 7A
TM4SF1 transmembrane 4 L six family member 1
TNS3 tensin 3
TRIM16 tripartite motif containing 16
TSKU tsukushi, small leucine rich proteoglycan
TSPAN3 tetraspanin 3
UPK1B uroplakin 1B
WWTR1 WW domain containing transcription regulator 1