BRD-A40431293_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

215 genes differentially expressed following the BRD-A40431293_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
AKAP13 A kinase (PRKA) anchor protein 13
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ARC activity-regulated cytoskeleton-associated protein
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARID4B AT rich interactive domain 4B (RBP1-like)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BAG3 BCL2-associated athanogene 3
BCL6 B-cell CLL/lymphoma 6
CA2 carbonic anhydrase II
CACYBP calcyclin binding protein
CBS cystathionine-beta-synthase
CCNA1 cyclin A1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CHIC2 cysteine-rich hydrophobic domain 2
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLDN3 claudin 3
CLU clusterin
COL1A1 collagen, type I, alpha 1
CRYAB crystallin, alpha B
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DOK5 docking protein 5
DTNA dystrobrevin, alpha
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
EIF1 eukaryotic translation initiation factor 1
EIF5 eukaryotic translation initiation factor 5
EPRS glutamyl-prolyl-tRNA synthetase
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FAS Fas cell surface death receptor
FHL2 four and a half LIM domains 2
FMOD fibromodulin
GAB2 GRB2-associated binding protein 2
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GSE1 Gse1 coiled-coil protein
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BK histone cluster 1, H2bk
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB1 heat shock 27kDa protein 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IER2 immediate early response 2
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGLJ3 immunoglobulin lambda joining 3
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
LARP6 La ribonucleoprotein domain family, member 6
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LTF lactotransferrin
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOB monoamine oxidase B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MME membrane metallo-endopeptidase
MMP1 matrix metallopeptidase 1
MMP11 matrix metallopeptidase 11
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MSX1 msh homeobox 1
MT1M metallothionein 1M
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO1D myosin ID
NAMPT nicotinamide phosphoribosyltransferase
NCOA3 nuclear receptor coactivator 3
NDRG1 N-myc downstream regulated 1
NEU1 sialidase 1 (lysosomal sialidase)
NFIL3 nuclear factor, interleukin 3 regulated
NUPL1 nucleoporin like 1
NUPR1 nuclear protein, transcriptional regulator, 1
ODC1 ornithine decarboxylase 1
OSER1 oxidative stress responsive serine-rich 1
PHGDH phosphoglycerate dehydrogenase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAP prosaposin
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RLF rearranged L-myc fusion
RNMT RNA (guanine-7-) methyltransferase
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SH3BGR SH3 domain binding glutamate-rich protein
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPAG9 sperm associated antigen 9
SPATS2L spermatogenesis associated, serine-rich 2-like
SQSTM1 sequestosome 1
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
TRIB3 tribbles pseudokinase 3
TXNRD1 thioredoxin reductase 1
UBB ubiquitin B
UPP1 uridine phosphorylase 1
XBP1 X-box binding protein 1
ZBTB10 zinc finger and BTB domain containing 10
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACSF2 acyl-CoA synthetase family member 2
AIM1 absent in melanoma 1
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
ASPH aspartate beta-hydroxylase
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BLCAP bladder cancer associated protein
BST2 bone marrow stromal cell antigen 2
CALD1 caldesmon 1
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCNA2 cyclin A2
CCND1 cyclin D1
CCNF cyclin F
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDC25B cell division cycle 25B
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CENPA centromere protein A
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTSC cathepsin C
CTSW cathepsin W
DUSP4 dual specificity phosphatase 4
FUBP1 far upstream element (FUSE) binding protein 1
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GOLGA8B golgin A8 family, member B
GTSE1 G-2 and S-phase expressed 1
HMG20B high mobility group 20B
HMGA2 high mobility group AT-hook 2
HN1L hematological and neurological expressed 1-like
ICMT isoprenylcysteine carboxyl methyltransferase
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
IGSF3 immunoglobulin superfamily, member 3
KIAA0907 KIAA0907
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KLHL9 kelch-like family member 9
KRT7 keratin 7, type II
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LUC7L3 LUC7-like 3 (S. cerevisiae)
LYPLA1 lysophospholipase I
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MARCKSL1 MARCKS-like 1
MAT2A methionine adenosyltransferase II, alpha
MCAM melanoma cell adhesion molecule
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NPY1R neuropeptide Y receptor Y1
NUP62 nucleoporin 62kDa
PEBP1 phosphatidylethanolamine binding protein 1
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLA2G16 phospholipase A2, group XVI
PLK1 polo-like kinase 1
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PPARG peroxisome proliferator-activated receptor gamma
PRSS23 protease, serine, 23
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SFRP1 secreted frizzled-related protein 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SMAD3 SMAD family member 3
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SPTSSA serine palmitoyltransferase, small subunit A
SRPX sushi-repeat containing protein, X-linked
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
THBS1 thrombospondin 1
TKTL1 transketolase-like 1
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TMEM223 transmembrane protein 223
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TOP2A topoisomerase (DNA) II alpha 170kDa
TUSC3 tumor suppressor candidate 3
TXLNA taxilin alpha
UBE2C ubiquitin-conjugating enzyme E2C
WWTR1 WW domain containing transcription regulator 1