BRD-A39996500_radicicol_SKBR3_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

150 genes differentially expressed following the BRD-A39996500_radicicol_SKBR3_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
ATP10B ATPase, class V, type 10B
BAG3 BCL2-associated athanogene 3
BIN1 bridging integrator 1
C10ORF10 chromosome 10 open reading frame 10
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CACYBP calcyclin binding protein
CCP110 centriolar coiled coil protein 110kDa
CD163 CD163 molecule
CD9 CD9 molecule
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CELF2 CUGBP, Elav-like family member 2
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DMBT1 deleted in malignant brain tumors 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
EPS8 epidermal growth factor receptor pathway substrate 8
FAM134B family with sequence similarity 134, member B
FCGBP Fc fragment of IgG binding protein
FXR1 fragile X mental retardation, autosomal homolog 1
GLTSCR2 glioma tumor suppressor candidate region gene 2
HCAR3 hydroxycarboxylic acid receptor 3
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HOXC10 homeobox C10
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFI6 interferon, alpha-inducible protein 6
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFIT5 interferon-induced protein with tetratricopeptide repeats 5
JMJD6 jumonji domain containing 6
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KRT23 keratin 23, type I
LY6E lymphocyte antigen 6 complex, locus E
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NPR3 natriuretic peptide receptor 3
NRN1 neuritin 1
NT5E 5'-nucleotidase, ecto (CD73)
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
PDZK1IP1 PDZK1 interacting protein 1
PLBD1 phospholipase B domain containing 1
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PRAME preferentially expressed antigen in melanoma
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RGS1 regulator of G-protein signaling 1
RHOB ras homolog family member B
RPS4Y1 ribosomal protein S4, Y-linked 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX9 SRY (sex determining region Y)-box 9
SPEN spen family transcriptional repressor
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STC2 stanniocalcin 2
TBC1D4 TBC1 domain family, member 4
TTN titin
VCAN versican
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA1 annexin A1
ANXA3 annexin A3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BASP1 brain abundant, membrane attached signal protein 1
CA12 carbonic anhydrase XII
CADM1 cell adhesion molecule 1
CALML5 calmodulin-like 5
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CASP2 caspase 2, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CCNB1 cyclin B1
CCND2 cyclin D2
CD24 CD24 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEMIP cell migration inducing protein, hyaluronan binding
CHN1 chimerin 1
CLIC3 chloride intracellular channel 3
COG7 component of oligomeric golgi complex 7
COL4A5 collagen, type IV, alpha 5
COMP cartilage oligomeric matrix protein
CPE carboxypeptidase E
CRIP2 cysteine-rich protein 2
CXCL9 chemokine (C-X-C motif) ligand 9
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK3 dickkopf WNT signaling pathway inhibitor 3
EIF4A1 eukaryotic translation initiation factor 4A1
EIF5A eukaryotic translation initiation factor 5A
F3 coagulation factor III (thromboplastin, tissue factor)
FAM129A family with sequence similarity 129, member A
GAS1 growth arrest-specific 1
GATA2 GATA binding protein 2
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
HES1 hes family bHLH transcription factor 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IL1R1 interleukin 1 receptor, type I
INSIG1 insulin induced gene 1
ITGB1BP1 integrin beta 1 binding protein 1
JAG1 jagged 1
KRT14 keratin 14, type I
KRT17 keratin 17, type I
LMO3 LIM domain only 3 (rhombotin-like 2)
LRRC17 leucine rich repeat containing 17
LTF lactotransferrin
LYZ lysozyme
NPIPB3 nuclear pore complex interacting protein family, member B3
OPN3 opsin 3
PA2G4 proliferation-associated 2G4, 38kDa
PCDH7 protocadherin 7
PEA15 phosphoprotein enriched in astrocytes 15
PLAT plasminogen activator, tissue
POSTN periostin, osteoblast specific factor
PRSS2 protease, serine, 2 (trypsin 2)
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
PTGDS prostaglandin D2 synthase 21kDa (brain)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP1 retinol binding protein 1, cellular
RGS4 regulator of G-protein signaling 4
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A9 S100 calcium binding protein A9
SDC1 syndecan 1
SDC2 syndecan 2
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SLPI secretory leukocyte peptidase inhibitor
SPON1 spondin 1, extracellular matrix protein
TFRC transferrin receptor
TMSB15A thymosin beta 15a
TNC tenascin C
TRIM29 tripartite motif containing 29
VAT1 vesicle amine transport 1
WT1 Wilms tumor 1
ZFP36L2 ZFP36 ring finger protein-like 2