BRD-A39996500_radicicol_SKBR3_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

220 genes differentially expressed following the BRD-A39996500_radicicol_SKBR3_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
ACSM3 acyl-CoA synthetase medium-chain family member 3
ADGRG6 adhesion G protein-coupled receptor G6
AHCYL1 adenosylhomocysteinase-like 1
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ARFIP2 ADP-ribosylation factor interacting protein 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAG3 BCL2-associated athanogene 3
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BCL6 B-cell CLL/lymphoma 6
BEX4 brain expressed, X-linked 4
CALCA calcitonin-related polypeptide alpha
CAPN6 calpain 6
CCNG1 cyclin G1
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK19 cyclin-dependent kinase 19
CFB complement factor B
COL2A1 collagen, type II, alpha 1
CORO1B coronin, actin binding protein, 1B
CRYZ crystallin, zeta (quinone reductase)
CTSH cathepsin H
CTSZ cathepsin Z
DLK1 delta-like 1 homolog (Drosophila)
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DPP4 dipeptidyl-peptidase 4
ECHDC2 enoyl CoA hydratase domain containing 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPB41L3 erythrocyte membrane protein band 4.1-like 3
ERBB3 erb-b2 receptor tyrosine kinase 3
FXR1 fragile X mental retardation, autosomal homolog 1
GAS1 growth arrest-specific 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLS glutaminase
GPATCH8 G patch domain containing 8
GRSF1 G-rich RNA sequence binding factor 1
GSTM3 glutathione S-transferase mu 3 (brain)
GSTT1 glutathione S-transferase theta 1
HIST3H2A histone cluster 3, H2a
HNMT histamine N-methyltransferase
HSPA1A heat shock 70kDa protein 1A
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IFITM1 interferon induced transmembrane protein 1
ITGA6 integrin, alpha 6
KLK11 kallikrein-related peptidase 11
MAN2A1 mannosidase, alpha, class 2A, member 1
MDFIC MyoD family inhibitor domain containing
MOAP1 modulator of apoptosis 1
MSLN mesothelin
MUC4 mucin 4, cell surface associated
MVP major vault protein
MYBPC1 myosin binding protein C, slow type
MYL1 myosin, light chain 1, alkali; skeletal, fast
MYO5C myosin VC
N4BP2L2 NEDD4 binding protein 2-like 2
NBR1 neighbor of BRCA1 gene 1
NEBL nebulette
NIPSNAP1 nipsnap homolog 1 (C. elegans)
OBSL1 obscurin-like 1
PCCA propionyl CoA carboxylase, alpha polypeptide
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDZK1IP1 PDZK1 interacting protein 1
PHACTR2 phosphatase and actin regulator 2
PLAGL1 pleiomorphic adenoma gene-like 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RHOBTB3 Rho-related BTB domain containing 3
RPL22 ribosomal protein L22
RPL31 ribosomal protein L31
RSL1D1 ribosomal L1 domain containing 1
S100A10 S100 calcium binding protein A10
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCRN1 secernin 1
SFTPB surfactant protein B
SFTPC surfactant protein C
SH3BP4 SH3-domain binding protein 4
SH3YL1 SH3 and SYLF domain containing 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC38A1 solute carrier family 38, member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SPAG16 sperm associated antigen 16
SPATA20 spermatogenesis associated 20
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TFRC transferrin receptor
TGFBR3 transforming growth factor, beta receptor III
TGM2 transglutaminase 2
TMEM5 transmembrane protein 5
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNC1 troponin C type 1 (slow)
TOB1 transducer of ERBB2, 1
TPD52L1 tumor protein D52-like 1
TRIB2 tribbles pseudokinase 2
TST thiosulfate sulfurtransferase (rhodanese)
TUG1 taurine up-regulated 1 (non-protein coding)
VAMP8 vesicle-associated membrane protein 8
WSCD1 WSC domain containing 1
XBP1 X-box binding protein 1
ZBTB18 zinc finger and BTB domain containing 18
ZKSCAN1 zinc finger with KRAB and SCAN domains 1
ZMYM2 zinc finger, MYM-type 2

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ACOT7 acyl-CoA thioesterase 7
ACTG2 actin, gamma 2, smooth muscle, enteric
ADD3 adducin 3 (gamma)
AEBP1 AE binding protein 1
AKAP12 A kinase (PRKA) anchor protein 12
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
BGN biglycan
BIRC2 baculoviral IAP repeat containing 2
C1ORF61 chromosome 1 open reading frame 61
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCL2 chemokine (C-C motif) ligand 2
CCNE2 cyclin E2
CD52 CD52 molecule
CD58 CD58 molecule
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CKAP4 cytoskeleton-associated protein 4
CLTB clathrin, light chain B
COL14A1 collagen, type XIV, alpha 1
CORO1A coronin, actin binding protein, 1A
CSRP1 cysteine and glycine-rich protein 1
CSTA cystatin A (stefin A)
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
DCK deoxycytidine kinase
DCLK1 doublecortin-like kinase 1
DHFR dihydrofolate reductase
DPYSL2 dihydropyrimidinase-like 2
DUSP4 dual specificity phosphatase 4
EGR2 early growth response 2
EGR3 early growth response 3
EIF5 eukaryotic translation initiation factor 5
EIF5A eukaryotic translation initiation factor 5A
ENO2 enolase 2 (gamma, neuronal)
EPHA3 EPH receptor A3
FCGBP Fc fragment of IgG binding protein
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXG1 forkhead box G1
FXYD6 FXYD domain containing ion transport regulator 6
GAL galanin/GMAP prepropeptide
GFOD1 glucose-fructose oxidoreductase domain containing 1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNAS GNAS complex locus
GPM6A glycoprotein M6A
HOXA10 homeobox A10
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL2RG interleukin 2 receptor, gamma
IL32 interleukin 32
INSIG1 insulin induced gene 1
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
JADE2 jade family PHD finger 2
JAG1 jagged 1
KLF4 Kruppel-like factor 4 (gut)
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT6B keratin 6B, type II
LINC00341 long intergenic non-protein coding RNA 341
LMO3 LIM domain only 3 (rhombotin-like 2)
LRRC17 leucine rich repeat containing 17
LTF lactotransferrin
MARCKS myristoylated alanine-rich protein kinase C substrate
MELK maternal embryonic leucine zipper kinase
MMP9 matrix metallopeptidase 9
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYH11 myosin, heavy chain 11, smooth muscle
MYLK myosin light chain kinase
NAV3 neuron navigator 3
NQO1 NAD(P)H dehydrogenase, quinone 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OLFM4 olfactomedin 4
PDE2A phosphodiesterase 2A, cGMP-stimulated
PNMA2 paraneoplastic Ma antigen 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPAP2B phosphatidic acid phosphatase type 2B
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCB protein kinase C, beta
PTN pleiotrophin
PYCR1 pyrroline-5-carboxylate reductase 1
RFTN1 raftlin, lipid raft linker 1
RRM2 ribonucleotide reductase M2
RTN1 reticulon 1
SDF2L1 stromal cell-derived factor 2-like 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SNAP25 synaptosomal-associated protein, 25kDa
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SYNM synemin, intermediate filament protein
SYT1 synaptotagmin I
TAGLN transgelin
THBS2 thrombospondin 2
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TRIB3 tribbles pseudokinase 3
TRMT5 tRNA methyltransferase 5
TUBB2A tubulin, beta 2A class IIa
TUBB4B tubulin, beta 4B class IVb
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ZFP36L2 ZFP36 ring finger protein-like 2