BRD-A39996500_radicicol_MDAMB231_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

210 genes differentially expressed following the BRD-A39996500_radicicol_MDAMB231_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACSL3 acyl-CoA synthetase long-chain family member 3
ADA adenosine deaminase
ADGRG2 adhesion G protein-coupled receptor G2
ASS1 argininosuccinate synthase 1
AURKA aurora kinase A
BEX1 brain expressed, X-linked 1
CBS cystathionine-beta-synthase
CCNB2 cyclin B2
CCNG1 cyclin G1
CKS2 CDC28 protein kinase regulatory subunit 2
CLU clusterin
COCH cochlin
COL11A1 collagen, type XI, alpha 1
COL5A2 collagen, type V, alpha 2
CPM carboxypeptidase M
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CXCL13 chemokine (C-X-C motif) ligand 13
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DLK1 delta-like 1 homolog (Drosophila)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DNTT DNA nucleotidylexotransferase
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFHD1 EF-hand domain family, member D1
EGFL6 EGF-like-domain, multiple 6
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPAS1 endothelial PAS domain protein 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
FTH1 ferritin, heavy polypeptide 1
FXR1 fragile X mental retardation, autosomal homolog 1
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GPC1 glypican 1
GPC3 glypican 3
GPX3 glutathione peroxidase 3
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPB8 heat shock 22kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP5 insulin-like growth factor binding protein 5
JMJD6 jumonji domain containing 6
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LDHB lactate dehydrogenase B
LXN latexin
LYPD1 LY6/PLAUR domain containing 1
MAGED1 melanoma antigen family D1
MAGED2 melanoma antigen family D2
MSMO1 methylsterol monooxygenase 1
MYH10 myosin, heavy chain 10, non-muscle
MYL9 myosin, light chain 9, regulatory
NID2 nidogen 2 (osteonidogen)
NISCH nischarin
NOTCH3 notch 3
OBSL1 obscurin-like 1
OSBPL9 oxysterol binding protein-like 9
OXTR oxytocin receptor
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PIR pirin (iron-binding nuclear protein)
PLK1 polo-like kinase 1
QPRT quinolinate phosphoribosyltransferase
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGS5 regulator of G-protein signaling 5
SC5D sterol-C5-desaturase
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFTPC surfactant protein C
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAP25 synaptosomal-associated protein, 25kDa
SQLE squalene epoxidase
STC2 stanniocalcin 2
STK26 serine/threonine protein kinase 26
TAC1 tachykinin, precursor 1
TNNT1 troponin T type 1 (skeletal, slow)
TSPAN13 tetraspanin 13
UFM1 ubiquitin-fold modifier 1
WFS1 Wolfram syndrome 1 (wolframin)

decreased expression

Symbol Name
ADORA2B adenosine A2b receptor
ADRB2 adrenoceptor beta 2, surface
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
ARL4C ADP-ribosylation factor-like 4C
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
AXL AXL receptor tyrosine kinase
CALML5 calmodulin-like 5
CCND1 cyclin D1
CCNE2 cyclin E2
CD44 CD44 molecule (Indian blood group)
CD58 CD58 molecule
CDCP1 CUB domain containing protein 1
COL14A1 collagen, type XIV, alpha 1
COTL1 coactosin-like F-actin binding protein 1
CPA3 carboxypeptidase A3 (mast cell)
CRIP2 cysteine-rich protein 2
CXCR4 chemokine (C-X-C motif) receptor 4
DDB2 damage-specific DNA binding protein 2, 48kDa
DHFR dihydrofolate reductase
DNMBP dynamin binding protein
DOCK4 dedicator of cytokinesis 4
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
ETV1 ets variant 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM129A family with sequence similarity 129, member A
FERMT1 fermitin family member 1
FOSL1 FOS-like antigen 1
FXYD3 FXYD domain containing ion transport regulator 3
FXYD5 FXYD domain containing ion transport regulator 5
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPI glucose-6-phosphate isomerase
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HMGA1 high mobility group AT-hook 1
IER2 immediate early response 2
IER3 immediate early response 3
IFI16 interferon, gamma-inducible protein 16
IFITM3 interferon induced transmembrane protein 3
IGHD immunoglobulin heavy constant delta
IL17RB interleukin 17 receptor B
ITGA6 integrin, alpha 6
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT1 keratin 1, type II
KRT6B keratin 6B, type II
LIF leukemia inhibitory factor
LPXN leupaxin
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MGLL monoglyceride lipase
MMP9 matrix metallopeptidase 9
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MTSS1 metastasis suppressor 1
MYO10 myosin X
NFE2L3 nuclear factor, erythroid 2-like 3
NREP neuronal regeneration related protein
NRP1 neuropilin 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PCNA proliferating cell nuclear antigen
PEA15 phosphoprotein enriched in astrocytes 15
PGRMC1 progesterone receptor membrane component 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLSCR1 phospholipid scramblase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKACB protein kinase, cAMP-dependent, catalytic, beta
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RFTN1 raftlin, lipid raft linker 1
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SDC1 syndecan 1
SDC4 syndecan 4
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SH2B3 SH2B adaptor protein 3
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC43A3 solute carrier family 43, member 3
SOX9 SRY (sex determining region Y)-box 9
SPP1 secreted phosphoprotein 1
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SRPX sushi-repeat containing protein, X-linked
SSFA2 sperm specific antigen 2
STX1A syntaxin 1A (brain)
SYNJ2 synaptojanin 2
SYNM synemin, intermediate filament protein
TAGLN2 transgelin 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF3 trefoil factor 3 (intestinal)
TGFA transforming growth factor, alpha
TKTL1 transketolase-like 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIB2 tribbles pseudokinase 2
TUBB2A tubulin, beta 2A class IIa
UPP1 uridine phosphorylase 1
VAT1 vesicle amine transport 1
WWTR1 WW domain containing transcription regulator 1
ZFP36L1 ZFP36 ring finger protein-like 1