BRD-A39996500_radicicol_MCF7_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

324 genes differentially expressed following the BRD-A39996500_radicicol_MCF7_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ABHD4 abhydrolase domain containing 4
ACSL3 acyl-CoA synthetase long-chain family member 3
ADAM10 ADAM metallopeptidase domain 10
ADI1 acireductone dioxygenase 1
ADM adrenomedullin
AFF1 AF4/FMR2 family, member 1
AKAP9 A kinase (PRKA) anchor protein 9
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AMACR alpha-methylacyl-CoA racemase
ANKMY2 ankyrin repeat and MYND domain containing 2
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
AURKA aurora kinase A
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BRD8 bromodomain containing 8
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CAB39 calcium binding protein 39
CALU calumenin
CAST calpastatin
CCDC28A coiled-coil domain containing 28A
CCNG2 cyclin G2
CD163 CD163 molecule
CD59 CD59 molecule, complement regulatory protein
CD99 CD99 molecule
CGA glycoprotein hormones, alpha polypeptide
CLDN8 claudin 8
COL2A1 collagen, type II, alpha 1
COL4A5 collagen, type IV, alpha 5
COL9A2 collagen, type IX, alpha 2
CPD carboxypeptidase D
CREB3L2 cAMP responsive element binding protein 3-like 2
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CRYZ crystallin, zeta (quinone reductase)
CSRP2 cysteine and glycine-rich protein 2
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
DHCR24 24-dehydrocholesterol reductase
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DUSP3 dual specificity phosphatase 3
DYNLRB1 dynein, light chain, roadblock-type 1
EFCAB14 EF-hand calcium binding domain 14
EGF epidermal growth factor
EPAS1 endothelial PAS domain protein 1
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB4 erb-b2 receptor tyrosine kinase 4
FADS2 fatty acid desaturase 2
FAM117A family with sequence similarity 117, member A
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
FOXJ3 forkhead box J3
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
FXR1 fragile X mental retardation, autosomal homolog 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GBE1 glucan (1,4-alpha-), branching enzyme 1
GCLC glutamate-cysteine ligase, catalytic subunit
GLUL glutamate-ammonia ligase
GPC3 glypican 3
GULP1 GULP, engulfment adaptor PTB domain containing 1
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HBP1 HMG-box transcription factor 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HGD homogentisate 1,2-dioxygenase
HLA-E major histocompatibility complex, class I, E
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP3 insulin-like growth factor binding protein 3
IGSF3 immunoglobulin superfamily, member 3
IL1R2 interleukin 1 receptor, type II
KDM3A lysine (K)-specific demethylase 3A
LIMCH1 LIM and calponin homology domains 1
LOC100272216 uncharacterized LOC100272216
LPAR1 lysophosphatidic acid receptor 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAOA monoamine oxidase A
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NDRG1 N-myc downstream regulated 1
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEFM neurofilament, medium polypeptide
NFE2L1 nuclear factor, erythroid 2-like 1
NPC2 Niemann-Pick disease, type C2
NPTX2 neuronal pentraxin II
NQO1 NAD(P)H dehydrogenase, quinone 1
OSBPL9 oxysterol binding protein-like 9
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDHX pyruvate dehydrogenase complex, component X
PDLIM4 PDZ and LIM domain 4
PERP PERP, TP53 apoptosis effector
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PINK1 PTEN induced putative kinase 1
PIR pirin (iron-binding nuclear protein)
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PROM1 prominin 1
QPRT quinolinate phosphoribosyltransferase
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RALGDS ral guanine nucleotide dissociation stimulator
RAP1GAP RAP1 GTPase activating protein
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBM47 RNA binding motif protein 47
SC5D sterol-C5-desaturase
SCPEP1 serine carboxypeptidase 1
SDCBP syndecan binding protein (syntenin)
SECISBP2L SECIS binding protein 2-like
SERINC1 serine incorporator 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFRP1 secreted frizzled-related protein 1
SFTPA2 surfactant protein A2
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SH3GLB1 SH3-domain GRB2-like endophilin B1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAP23 synaptosomal-associated protein, 23kDa
SORD sorbitol dehydrogenase
STC1 stanniocalcin 1
STOM stomatin
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TBL1X transducin (beta)-like 1X-linked
TBX3 T-box 3
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGM2 transglutaminase 2
TMEM41B transmembrane protein 41B
TMEM45A transmembrane protein 45A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSKU tsukushi, small leucine rich proteoglycan
TTC39A tetratricopeptide repeat domain 39A
TXNIP thioredoxin interacting protein
TXNRD1 thioredoxin reductase 1
UBXN7 UBX domain protein 7
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UFM1 ubiquitin-fold modifier 1
VAMP8 vesicle-associated membrane protein 8
VAV3 vav 3 guanine nucleotide exchange factor
WIPI1 WD repeat domain, phosphoinositide interacting 1
WSB1 WD repeat and SOCS box containing 1
XCL1 chemokine (C motif) ligand 1
YPEL5 yippee-like 5 (Drosophila)
ZMYND8 zinc finger, MYND-type containing 8

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
AKAP12 A kinase (PRKA) anchor protein 12
AREG amphiregulin
ASF1B anti-silencing function 1B histone chaperone
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASRGL1 asparaginase like 1
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
BRCA1 breast cancer 1, early onset
C3 complement component 3
CAPN3 calpain 3, (p94)
CAV1 caveolin 1, caveolae protein, 22kDa
CCDC85B coiled-coil domain containing 85B
CCNE2 cyclin E2
CD47 CD47 molecule
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK2 cyclin-dependent kinase 2
CDK4 cyclin-dependent kinase 4
CENPU centromere protein U
CHN2 chimerin 2
CKLF chemokine-like factor
CLTB clathrin, light chain B
CSTA cystatin A (stefin A)
CTPS1 CTP synthase 1
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
DCLK1 doublecortin-like kinase 1
DCT dopachrome tautomerase
DCTPP1 dCTP pyrophosphatase 1
DHFR dihydrofolate reductase
DONSON downstream neighbor of SON
DPH2 DPH2 homolog (S. cerevisiae)
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
EGR3 early growth response 3
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ENO1 enolase 1, (alpha)
EREG epiregulin
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F12 coagulation factor XII (Hageman factor)
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM216A family with sequence similarity 216, member A
FEN1 flap structure-specific endonuclease 1
FHL1 four and a half LIM domains 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GALE UDP-galactose-4-epimerase
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPM6A glycoprotein M6A
H2AFX H2A histone family, member X
HIST1H4C histone cluster 1, H4c
HN1 hematological and neurological expressed 1
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFI44L interferon-induced protein 44-like
IFITM1 interferon induced transmembrane protein 1
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
ISG15 ISG15 ubiquitin-like modifier
JAG1 jagged 1
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KRT23 keratin 23, type I
LAGE3 L antigen family, member 3
LGALS4 lectin, galactoside-binding, soluble, 4
LIF leukemia inhibitory factor
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LOXL1 lysyl oxidase-like 1
LRRC17 leucine rich repeat containing 17
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LYZ lysozyme
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MBP myelin basic protein
MCL1 myeloid cell leukemia 1
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MGP matrix Gla protein
MLANA melan-A
MRPL15 mitochondrial ribosomal protein L15
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBL1 neuroblastoma 1, DAN family BMP antagonist
NELL2 NEL-like 2 (chicken)
NME1 NME/NM23 nucleoside diphosphate kinase 1
NMU neuromedin U
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP56 NOP56 ribonucleoprotein
NR2F1 nuclear receptor subfamily 2, group F, member 1
NUP85 nucleoporin 85kDa
NXT1 nuclear transport factor 2-like export factor 1
OAT ornithine aminotransferase
OLFM4 olfactomedin 4
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PAQR4 progestin and adipoQ receptor family member IV
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCNA proliferating cell nuclear antigen
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLSCR1 phospholipid scramblase 1
PNP purine nucleoside phosphorylase
PPA1 pyrophosphatase (inorganic) 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRR7 proline rich 7 (synaptic)
PRSS2 protease, serine, 2 (trypsin 2)
PRSS3 protease, serine, 3
PYCR1 pyrroline-5-carboxylate reductase 1
RAB31 RAB31, member RAS oncogene family
RAD51 RAD51 recombinase
RANBP1 RAN binding protein 1
RBBP8 retinoblastoma binding protein 8
RFC2 replication factor C (activator 1) 2, 40kDa
RFK riboflavin kinase
RGS16 regulator of G-protein signaling 16
RNASEH2A ribonuclease H2, subunit A
RPIA ribose 5-phosphate isomerase A
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SLBP stem-loop binding protein
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SMAD1 SMAD family member 1
SPC25 SPC25, NDC80 kinetochore complex component
SPINK1 serine peptidase inhibitor, Kazal type 1
SPP1 secreted phosphoprotein 1
SPRED2 sprouty-related, EVH1 domain containing 2
SRM spermidine synthase
SRSF7 serine/arginine-rich splicing factor 7
TACSTD2 tumor-associated calcium signal transducer 2
TAGLN transgelin
TFDP1 transcription factor Dp-1
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
THBS1 thrombospondin 1
TIPIN TIMELESS interacting protein
TJP2 tight junction protein 2
TK1 thymidine kinase 1, soluble
TMEM109 transmembrane protein 109
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM176B transmembrane protein 176B
TMEM251 transmembrane protein 251
TMPO thymopoietin
TMSB15A thymosin beta 15a
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TOR3A torsin family 3, member A
TYRP1 tyrosinase-related protein 1
VCAM1 vascular cell adhesion molecule 1
ZFPM2 zinc finger protein, FOG family member 2