BRD-A39996500_radicicol_MCF10A_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

234 genes differentially expressed following the BRD-A39996500_radicicol_MCF10A_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADCK3 aarF domain containing kinase 3
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
C3ORF14 chromosome 3 open reading frame 14
CACYBP calcyclin binding protein
CADM1 cell adhesion molecule 1
CD40 CD40 molecule, TNF receptor superfamily member 5
CES1 carboxylesterase 1
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
COL5A2 collagen, type V, alpha 2
CSRP2 cysteine and glycine-rich protein 2
DEFB1 defensin, beta 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNTT DNA nucleotidylexotransferase
ENO2 enolase 2 (gamma, neuronal)
FTH1 ferritin, heavy polypeptide 1
FXR1 fragile X mental retardation, autosomal homolog 1
GCLM glutamate-cysteine ligase, modifier subunit
GSTM3 glutathione S-transferase mu 3 (brain)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IGKV4-1 immunoglobulin kappa variable 4-1
JMJD6 jumonji domain containing 6
KIF14 kinesin family member 14
KRT13 keratin 13, type I
LEF1 lymphoid enhancer-binding factor 1
LY6D lymphocyte antigen 6 complex, locus D
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAGEA6 melanoma antigen family A6
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP7 matrix metallopeptidase 7
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MZB1 marginal zone B and B1 cell-specific protein
NDRG1 N-myc downstream regulated 1
NEFL neurofilament, light polypeptide
NELL2 NEL-like 2 (chicken)
NOTCH1 notch 1
NOTCH3 notch 3
NR1H2 nuclear receptor subfamily 1, group H, member 2
NRCAM neuronal cell adhesion molecule
NUPR1 nuclear protein, transcriptional regulator, 1
ODAM odontogenic, ameloblast asssociated
OXTR oxytocin receptor
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PIR pirin (iron-binding nuclear protein)
POU2AF1 POU class 2 associating factor 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
QPRT quinolinate phosphoribosyltransferase
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPW1 selenoprotein W, 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SPATA20 spermatogenesis associated 20
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SPRR3 small proline-rich protein 3
SQSTM1 sequestosome 1
THBS4 thrombospondin 4
TIAM1 T-cell lymphoma invasion and metastasis 1
TMEM45A transmembrane protein 45A
TMEM97 transmembrane protein 97
TSPAN13 tetraspanin 13
TSPAN7 tetraspanin 7
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WWP1 WW domain containing E3 ubiquitin protein ligase 1

decreased expression

Symbol Name
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ADIPOQ adiponectin, C1Q and collagen domain containing
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADORA2B adenosine A2b receptor
ADRB2 adrenoceptor beta 2, surface
AGTR1 angiotensin II receptor, type 1
AIM1 absent in melanoma 1
AKAP12 A kinase (PRKA) anchor protein 12
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMIGO2 adhesion molecule with Ig-like domain 2
AOX1 aldehyde oxidase 1
APOD apolipoprotein D
APOLD1 apolipoprotein L domain containing 1
AREG amphiregulin
ARHGAP12 Rho GTPase activating protein 12
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BASP1 brain abundant, membrane attached signal protein 1
BHLHE40 basic helix-loop-helix family, member e40
C3 complement component 3
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCND2 cyclin D2
CLDN8 claudin 8
CLMN calmin (calponin-like, transmembrane)
CPM carboxypeptidase M
CST7 cystatin F (leukocystatin)
CSTA cystatin A (stefin A)
CTGF connective tissue growth factor
CTSG cathepsin G
CYBRD1 cytochrome b reductase 1
DCLK1 doublecortin-like kinase 1
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLK1 delta-like 1 homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
ELANE elastase, neutrophil expressed
EMP1 epithelial membrane protein 1
EPCAM epithelial cell adhesion molecule
EREG epiregulin
F13A1 coagulation factor XIII, A1 polypeptide
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FABP4 fatty acid binding protein 4, adipocyte
FAM3C family with sequence similarity 3, member C
FGF9 fibroblast growth factor 9
FHL2 four and a half LIM domains 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FST follistatin
GADD45A growth arrest and DNA-damage-inducible, alpha
GAS1 growth arrest-specific 1
GSN gelsolin
GSPT1 G1 to S phase transition 1
HBB hemoglobin, beta
HES1 hes family bHLH transcription factor 1
HMGA2 high mobility group AT-hook 2
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IER3 immediate early response 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IRS2 insulin receptor substrate 2
JADE2 jade family PHD finger 2
JAG1 jagged 1
JUNB jun B proto-oncogene
KLF10 Kruppel-like factor 10
LGALS1 lectin, galactoside-binding, soluble, 1
LIF leukemia inhibitory factor
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MT1E metallothionein 1E
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MTSS1 metastasis suppressor 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFIB nuclear factor I/B
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOV nephroblastoma overexpressed
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NT5E 5'-nucleotidase, ecto (CD73)
OSBPL10 oxysterol binding protein-like 10
PALLD palladin, cytoskeletal associated protein
PDE4D phosphodiesterase 4D, cAMP-specific
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDLIM5 PDZ and LIM domain 5
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PEG10 paternally expressed 10
PER1 period circadian clock 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PKP2 plakophilin 2
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PRPF4 pre-mRNA processing factor 4
PRSS21 protease, serine, 21 (testisin)
PTGDS prostaglandin D2 synthase 21kDa (brain)
RGCC regulator of cell cycle
RNASE3 ribonuclease, RNase A family, 3
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SCG2 secretogranin II
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP1 secreted frizzled-related protein 1
SIK1 salt-inducible kinase 1
SNAP25 synaptosomal-associated protein, 25kDa
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFPI2 tissue factor pathway inhibitor 2
TFRC transferrin receptor
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGFBR3 transforming growth factor, beta receptor III
THBS1 thrombospondin 1
TIMP1 TIMP metallopeptidase inhibitor 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMC5 transmembrane channel-like 5
TMEM176B transmembrane protein 176B
TMX4 thioredoxin-related transmembrane protein 4
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TOX3 TOX high mobility group box family member 3
TSC22D3 TSC22 domain family, member 3
TSPAN8 tetraspanin 8
TXNIP thioredoxin interacting protein
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
VSNL1 visinin-like 1
WEE1 WEE1 G2 checkpoint kinase
ZDHHC6 zinc finger, DHHC-type containing 6
ZFP36 ZFP36 ring finger protein