BRD-A39996500_radicicol_LNCAP_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

237 genes differentially expressed following the BRD-A39996500_radicicol_LNCAP_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BAMBI BMP and activin membrane-bound inhibitor
BEX1 brain expressed, X-linked 1
BEX4 brain expressed, X-linked 4
BTG2 BTG family, member 2
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CCNG1 cyclin G1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLU clusterin
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL4A5 collagen, type IV, alpha 5
COL6A3 collagen, type VI, alpha 3
COLEC12 collectin sub-family member 12
CPM carboxypeptidase M
CTSA cathepsin A
DLK1 delta-like 1 homolog (Drosophila)
DRAM1 DNA-damage regulated autophagy modulator 1
ECM1 extracellular matrix protein 1
EDN3 endothelin 3
EGF epidermal growth factor
EPCAM epithelial cell adhesion molecule
F13A1 coagulation factor XIII, A1 polypeptide
FAM129A family with sequence similarity 129, member A
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FGF13 fibroblast growth factor 13
FGG fibrinogen gamma chain
FN1 fibronectin 1
FXR1 fragile X mental retardation, autosomal homolog 1
GSN gelsolin
HECA headcase homolog (Drosophila)
HIST1H2AC histone cluster 1, H2ac
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HOPX HOP homeobox
HSPB1 heat shock 27kDa protein 1
HSPB8 heat shock 22kDa protein 8
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IDS iduronate 2-sulfatase
IFI27 interferon, alpha-inducible protein 27
IGFBP7 insulin-like growth factor binding protein 7
ITM2A integral membrane protein 2A
KRT18 keratin 18, type I
LAPTM4B lysosomal protein transmembrane 4 beta
MAOA monoamine oxidase A
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MIR22HG MIR22 host gene
MYL9 myosin, light chain 9, regulatory
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NET1 neuroepithelial cell transforming 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLBD1 phospholipase B domain containing 1
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha
PRSS23 protease, serine, 23
PYGL phosphorylase, glycogen, liver
QPRT quinolinate phosphoribosyltransferase
QSOX1 quiescin Q6 sulfhydryl oxidase 1
RAI14 retinoic acid induced 14
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RBP1 retinol binding protein 1, cellular
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RRAGD Ras-related GTP binding D
SAT1 spermidine/spermine N1-acetyltransferase 1
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SESN1 sestrin 1
STOM stomatin
TCTA T-cell leukemia translocation altered
TPP1 tripeptidyl peptidase I
TUBB6 tubulin, beta 6 class V
YPEL5 yippee-like 5 (Drosophila)
ZMAT3 zinc finger, matrin-type 3
ZNF91 zinc finger protein 91
ZYX zyxin

decreased expression

Symbol Name
ADGRG6 adhesion G protein-coupled receptor G6
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BLNK B-cell linker
BRCA1 breast cancer 1, early onset
BTG3 BTG family, member 3
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
BUB3 BUB3 mitotic checkpoint protein
C2CD5 C2 calcium-dependent domain containing 5
CCNA2 cyclin A2
CCNB1 cyclin B1
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDCA3 cell division cycle associated 3
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDT1 chromatin licensing and DNA replication factor 1
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CIT citron rho-interacting serine/threonine kinase
CKAP2 cytoskeleton associated protein 2
CKS1B CDC28 protein kinase regulatory subunit 1B
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DBF4 DBF4 zinc finger
DCK deoxycytidine kinase
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
ECT2 epithelial cell transforming 2
ELOVL2 ELOVL fatty acid elongase 2
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FANCG Fanconi anemia, complementation group G
FANCI Fanconi anemia, complementation group I
FBXO5 F-box protein 5
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
FOXM1 forkhead box M1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPM6B glycoprotein M6B
GPX2 glutathione peroxidase 2
GTSE1 G-2 and S-phase expressed 1
H1FX H1 histone family, member X
H2AFX H2A histone family, member X
H2AFZ H2A histone family, member Z
HJURP Holliday junction recognition protein
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF22 kinesin family member 22
KIF23 kinesin family member 23
KIF4A kinesin family member 4A
KIFC1 kinesin family member C1
KNTC1 kinetochore associated 1
LAMP5 lysosomal-associated membrane protein family, member 5
LMNB1 lamin B1
LMNB2 lamin B2
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MMP3 matrix metallopeptidase 3
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPD3 non-SMC condensin II complex, subunit D3
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEK2 NIMA-related kinase 2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
PAN2 PAN2 poly(A) specific ribonuclease subunit
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PSRC1 proline/serine-rich coiled-coil 1
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
PTTG1 pituitary tumor-transforming 1
RACGAP1 Rac GTPase activating protein 1
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RANBP1 RAN binding protein 1
RCAN1 regulator of calcineurin 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RNASEH2A ribonuclease H2, subunit A
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SOX11 SRY (sex determining region Y)-box 11
SPC25 SPC25, NDC80 kinetochore complex component
SPON1 spondin 1, extracellular matrix protein
TACC3 transforming, acidic coiled-coil containing protein 3
TBC1D31 TBC1 domain family, member 31
TBX2 T-box 2
TDO2 tryptophan 2,3-dioxygenase
TK1 thymidine kinase 1, soluble
TMEM194A transmembrane protein 194A
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRMT5 tRNA methyltransferase 5
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
VRK1 vaccinia related kinase 1
WHSC1 Wolf-Hirschhorn syndrome candidate 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWILCH zwilch kinetochore protein
ZWINT ZW10 interacting kinetochore protein