BRD-A39996500_radicicol_HS578T_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

148 genes differentially expressed following the BRD-A39996500_radicicol_HS578T_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AQP3 aquaporin 3 (Gill blood group)
AQP9 aquaporin 9
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
AXIN1 axin 1
BAG3 BCL2-associated athanogene 3
CACYBP calcyclin binding protein
CASP7 caspase 7, apoptosis-related cysteine peptidase
CECR1 cat eye syndrome chromosome region, candidate 1
CES1 carboxylesterase 1
CFB complement factor B
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLDN10 claudin 10
CLU clusterin
CXCL13 chemokine (C-X-C motif) ligand 13
DDIT4 DNA-damage-inducible transcript 4
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EYA2 EYA transcriptional coactivator and phosphatase 2
FASN fatty acid synthase
FBP1 fructose-1,6-bisphosphatase 1
FCHO1 FCH domain only 1
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FLRT3 fibronectin leucine rich transmembrane protein 3
GJA1 gap junction protein, alpha 1, 43kDa
HEBP1 heme binding protein 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
JMJD6 jumonji domain containing 6
LIMCH1 LIM and calponin homology domains 1
LYZ lysozyme
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP12 matrix metallopeptidase 12
MMP7 matrix metallopeptidase 7
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEBL nebulette
NEFM neurofilament, medium polypeptide
NOTCH1 notch 1
NRIP3 nuclear receptor interacting protein 3
PIR pirin (iron-binding nuclear protein)
PLBD1 phospholipase B domain containing 1
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RGS4 regulator of G-protein signaling 4
RPS11 ribosomal protein S11
SAT1 spermidine/spermine N1-acetyltransferase 1
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SFTPC surfactant protein C
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
TLR4 toll-like receptor 4
TRD T cell receptor delta locus
TREM1 triggering receptor expressed on myeloid cells 1
TSPYL5 TSPY-like 5
TUSC3 tumor suppressor candidate 3
VCAM1 vascular cell adhesion molecule 1
WDR7 WD repeat domain 7

decreased expression

Symbol Name
ANXA3 annexin A3
APOD apolipoprotein D
AREG amphiregulin
ARG1 arginase 1
ARL4C ADP-ribosylation factor-like 4C
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCND2 cyclin D2
CREB1 cAMP responsive element binding protein 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DPP4 dipeptidyl-peptidase 4
DPT dermatopontin
ECM1 extracellular matrix protein 1
EDN1 endothelin 1
EREG epiregulin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FBN1 fibrillin 1
FOSL1 FOS-like antigen 1
FST follistatin
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPM6A glycoprotein M6A
GPRC5B G protein-coupled receptor, class C, group 5, member B
GPX1 glutathione peroxidase 1
HDAC9 histone deacetylase 9
HES1 hes family bHLH transcription factor 1
HOXA5 homeobox A5
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFI16 interferon, gamma-inducible protein 16
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KRT23 keratin 23, type I
LAMA3 laminin, alpha 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MFAP5 microfibrillar associated protein 5
MGLL monoglyceride lipase
MGP matrix Gla protein
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRN1 neuritin 1
NT5E 5'-nucleotidase, ecto (CD73)
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OXTR oxytocin receptor
PCNA proliferating cell nuclear antigen
PDGFC platelet derived growth factor C
PERP PERP, TP53 apoptosis effector
PSPH phosphoserine phosphatase
PTGDS prostaglandin D2 synthase 21kDa (brain)
RHOBTB3 Rho-related BTB domain containing 3
RRAS2 related RAS viral (r-ras) oncogene homolog 2
S100P S100 calcium binding protein P
SFRP1 secreted frizzled-related protein 1
SRPX sushi-repeat containing protein, X-linked
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TF transferrin
TFPI2 tissue factor pathway inhibitor 2
THBS2 thrombospondin 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM158 transmembrane protein 158 (gene/pseudogene)
TSPAN8 tetraspanin 8
TXNIP thioredoxin interacting protein
UGCG UDP-glucose ceramide glucosyltransferase
VCAN versican
VGLL4 vestigial-like family member 4
WASF3 WAS protein family, member 3
WT1 Wilms tumor 1
WWTR1 WW domain containing transcription regulator 1