BRD-A39996500_radicicol_HS578T_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

267 genes differentially expressed following the BRD-A39996500_radicicol_HS578T_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
AFF1 AF4/FMR2 family, member 1
ALCAM activated leukocyte cell adhesion molecule
APOL1 apolipoprotein L, 1
ASS1 argininosuccinate synthase 1
ATF5 activating transcription factor 5
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BBX bobby sox homolog (Drosophila)
BID BH3 interacting domain death agonist
CA12 carbonic anhydrase XII
CCL20 chemokine (C-C motif) ligand 20
CCNB2 cyclin B2
CCNG1 cyclin G1
CDK19 cyclin-dependent kinase 19
CENPE centromere protein E, 312kDa
CHN1 chimerin 1
CKS2 CDC28 protein kinase regulatory subunit 2
COBL cordon-bleu WH2 repeat protein
COL4A5 collagen, type IV, alpha 5
COL9A2 collagen, type IX, alpha 2
CRABP1 cellular retinoic acid binding protein 1
CTSH cathepsin H
CTSZ cathepsin Z
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
DEFA4 defensin, alpha 4, corticostatin
DENND1B DENN/MADD domain containing 1B
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DUSP3 dual specificity phosphatase 3
ENO1 enolase 1, (alpha)
EPAS1 endothelial PAS domain protein 1
ERO1L ERO1-like (S. cerevisiae)
FASTKD5 FAST kinase domains 5
FBP1 fructose-1,6-bisphosphatase 1
FGB fibrinogen beta chain
FLNB filamin B, beta
FOXD1 forkhead box D1
FXR1 fragile X mental retardation, autosomal homolog 1
FZD10 frizzled class receptor 10
GAS6 growth arrest-specific 6
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GPRC5A G protein-coupled receptor, class C, group 5, member A
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
GZMK granzyme K (granzyme 3; tryptase II)
HIST1H2BG histone cluster 1, H2bg
HMG20B high mobility group 20B
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IDO1 indoleamine 2,3-dioxygenase 1
IGFBP4 insulin-like growth factor binding protein 4
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
IL7R interleukin 7 receptor
IRX5 iroquois homeobox 5
ITM2C integral membrane protein 2C
JMJD6 jumonji domain containing 6
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KDM4B lysine (K)-specific demethylase 4B
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LDHB lactate dehydrogenase B
LTF lactotransferrin
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAOA monoamine oxidase A
MFAP5 microfibrillar associated protein 5
MKNK2 MAP kinase interacting serine/threonine kinase 2
MMP9 matrix metallopeptidase 9
MOB1A MOB kinase activator 1A
MSMB microseminoprotein, beta-
MT1F metallothionein 1F
MYO1B myosin IB
NAP1L1 nucleosome assembly protein 1-like 1
NDRG1 N-myc downstream regulated 1
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NME4 NME/NM23 nucleoside diphosphate kinase 4
NOTCH3 notch 3
NXN nucleoredoxin
OLA1 Obg-like ATPase 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PGK1 phosphoglycerate kinase 1
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PRKCH protein kinase C, eta
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RPL28 ribosomal protein L28
S100A10 S100 calcium binding protein A10
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPINK1 serine peptidase inhibitor, Kazal type 1
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SPTAN1 spectrin, alpha, non-erythrocytic 1
STC1 stanniocalcin 1
TACSTD2 tumor-associated calcium signal transducer 2
TGFA transforming growth factor, alpha
TGM2 transglutaminase 2
THSD7A thrombospondin, type I, domain containing 7A
TOB1 transducer of ERBB2, 1
TPM4 tropomyosin 4
TRIM2 tripartite motif containing 2
TSPAN13 tetraspanin 13
TSPYL5 TSPY-like 5
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VAMP8 vesicle-associated membrane protein 8

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ACTA2 actin, alpha 2, smooth muscle, aorta
ADIPOQ adiponectin, C1Q and collagen domain containing
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALOX5 arachidonate 5-lipoxygenase
AMDHD2 amidohydrolase domain containing 2
AMIGO2 adhesion molecule with Ig-like domain 2
APOD apolipoprotein D
ARL4C ADP-ribosylation factor-like 4C
BAALC brain and acute leukemia, cytoplasmic
C1QTNF3 C1q and tumor necrosis factor related protein 3
C2CD5 C2 calcium-dependent domain containing 5
C3ORF14 chromosome 3 open reading frame 14
CALML5 calmodulin-like 5
CCNE2 cyclin E2
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CDC45 cell division cycle 45
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHGB chromogranin B
CHN2 chimerin 2
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CIRBP cold inducible RNA binding protein
CLEC2B C-type lectin domain family 2, member B
COL11A1 collagen, type XI, alpha 1
COMP cartilage oligomeric matrix protein
CRYAB crystallin, alpha B
CTSA cathepsin A
CXCL12 chemokine (C-X-C motif) ligand 12
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCK deoxycytidine kinase
DDB2 damage-specific DNA binding protein 2, 48kDa
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DHRS2 dehydrogenase/reductase (SDR family) member 2
DUSP22 dual specificity phosphatase 22
EGFR epidermal growth factor receptor
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPHB2 EPH receptor B2
EREG epiregulin
ETV1 ets variant 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM3C family with sequence similarity 3, member C
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
GATA6 GATA binding protein 6
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GEM GTP binding protein overexpressed in skeletal muscle
GFOD1 glucose-fructose oxidoreductase domain containing 1
GJA1 gap junction protein, alpha 1, 43kDa
GPNMB glycoprotein (transmembrane) nmb
GREM1 gremlin 1, DAN family BMP antagonist
GSTA4 glutathione S-transferase alpha 4
GTPBP8 GTP-binding protein 8 (putative)
GULP1 GULP, engulfment adaptor PTB domain containing 1
GUSB glucuronidase, beta
HMGA2 high mobility group AT-hook 2
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI16 interferon, gamma-inducible protein 16
IFI44L interferon-induced protein 44-like
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGF1R insulin-like growth factor 1 receptor
IGFBP5 insulin-like growth factor binding protein 5
IL1R1 interleukin 1 receptor, type I
INHBA inhibin, beta A
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
INSIG1 insulin induced gene 1
KIAA0485 uncharacterized LOC57235
KLF4 Kruppel-like factor 4 (gut)
KRT1 keratin 1, type II
KRT14 keratin 14, type I
KRT6B keratin 6B, type II
LAMA3 laminin, alpha 3
LIF leukemia inhibitory factor
LIG1 ligase I, DNA, ATP-dependent
LIPA lipase A, lysosomal acid, cholesterol esterase
LRRC17 leucine rich repeat containing 17
LSP1 lymphocyte-specific protein 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MANSC1 MANSC domain containing 1
MAP7 microtubule-associated protein 7
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MFAP4 microfibrillar-associated protein 4
MMP7 matrix metallopeptidase 7
MTCL1 microtubule crosslinking factor 1
MTSS1 metastasis suppressor 1
NREP neuronal regeneration related protein
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PAN2 PAN2 poly(A) specific ribonuclease subunit
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCNA proliferating cell nuclear antigen
PDGFD platelet derived growth factor D
PEG10 paternally expressed 10
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLIN1 perilipin 1
PNP purine nucleoside phosphorylase
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRPF4 pre-mRNA processing factor 4
PTGIS prostaglandin I2 (prostacyclin) synthase
PTN pleiotrophin
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RFC2 replication factor C (activator 1) 2, 40kDa
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPL10 ribosomal protein L10
RRAGD Ras-related GTP binding D
S100A2 S100 calcium binding protein A2
SCGB1D2 secretoglobin, family 1D, member 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SOAT1 sterol O-acyltransferase 1
SOX9 SRY (sex determining region Y)-box 9
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SRM spermidine synthase
SST somatostatin
SULF1 sulfatase 1
SYBU syntabulin (syntaxin-interacting)
SYT1 synaptotagmin I
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TIMP4 TIMP metallopeptidase inhibitor 4
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM176B transmembrane protein 176B
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TPP1 tripeptidyl peptidase I
TPR translocated promoter region, nuclear basket protein
USP1 ubiquitin specific peptidase 1
VSNL1 visinin-like 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WNT5A wingless-type MMTV integration site family, member 5A
ZDHHC6 zinc finger, DHHC-type containing 6
ZFPM2 zinc finger protein, FOG family member 2