BRD-A39996500_radicicol_HME1_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

151 genes differentially expressed following the BRD-A39996500_radicicol_HME1_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANXA10 annexin A10
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
BAG3 BCL2-associated athanogene 3
BLNK B-cell linker
BLVRB biliverdin reductase B
CALML4 calmodulin-like 4
CDC6 cell division cycle 6
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CRELD2 cysteine-rich with EGF-like domains 2
CTSE cathepsin E
CXCL9 chemokine (C-X-C motif) ligand 9
DDIT3 DNA-damage-inducible transcript 3
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
FGFR2 fibroblast growth factor receptor 2
FOLR1 folate receptor 1 (adult)
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GCLM glutamate-cysteine ligase, modifier subunit
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
GUSBP11 glucuronidase, beta pseudogene 11
HBD hemoglobin, delta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
HYOU1 hypoxia up-regulated 1
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGLJ3 immunoglobulin lambda joining 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV2-23 immunoglobulin lambda variable 2-23
IRF8 interferon regulatory factor 8
JAG1 jagged 1
JCHAIN joining chain of multimeric IgA and IgM
JMJD6 jumonji domain containing 6
LONP2 lon peptidase 2, peroxisomal
MANF mesencephalic astrocyte-derived neurotrophic factor
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MSX1 msh homeobox 1
NQO1 NAD(P)H dehydrogenase, quinone 1
OSER1 oxidative stress responsive serine-rich 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCBP2 poly(rC) binding protein 2
PCCB propionyl CoA carboxylase, beta polypeptide
PDIA4 protein disulfide isomerase family A, member 4
PIR pirin (iron-binding nuclear protein)
PLK2 polo-like kinase 2
POU2AF1 POU class 2 associating factor 1
PPIB peptidylprolyl isomerase B (cyclophilin B)
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRAME preferentially expressed antigen in melanoma
PRDX2 peroxiredoxin 2
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
RAD9A RAD9 homolog A (S. pombe)
RPL38 ribosomal protein L38
S100P S100 calcium binding protein P
SDF2L1 stromal cell-derived factor 2-like 1
SEC24D SEC24 family member D
SLC38A1 solute carrier family 38, member 1
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX9 SRY (sex determining region Y)-box 9
SRSF6 serine/arginine-rich splicing factor 6
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TLR4 toll-like receptor 4
TRA2A transformer 2 alpha homolog (Drosophila)
TXNRD1 thioredoxin reductase 1
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
AREG amphiregulin
ARL4C ADP-ribosylation factor-like 4C
ASS1 argininosuccinate synthase 1
C8ORF4 chromosome 8 open reading frame 4
CCNF cyclin F
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CXCL8 chemokine (C-X-C motif) ligand 8
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DMD dystrophin
E2F5 E2F transcription factor 5, p130-binding
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ELN elastin
ELOVL5 ELOVL fatty acid elongase 5
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
F13A1 coagulation factor XIII, A1 polypeptide
FAM120A family with sequence similarity 120A
FGFR3 fibroblast growth factor receptor 3
FZD7 frizzled class receptor 7
GAS1 growth arrest-specific 1
GLUL glutamate-ammonia ligase
GPSM2 G-protein signaling modulator 2
HES1 hes family bHLH transcription factor 1
HILPDA hypoxia inducible lipid droplet-associated
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IL1RAP interleukin 1 receptor accessory protein
JADE2 jade family PHD finger 2
LUM lumican
METTL7A methyltransferase like 7A
MMD monocyte to macrophage differentiation-associated
MTSS1 metastasis suppressor 1
MXRA5 matrix-remodelling associated 5
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PBX3 pre-B-cell leukemia homeobox 3
PDE9A phosphodiesterase 9A
PDGFA platelet-derived growth factor alpha polypeptide
PEG10 paternally expressed 10
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
QKI QKI, KH domain containing, RNA binding
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RNF144A ring finger protein 144A
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A8 S100 calcium binding protein A8
SOX4 SRY (sex determining region Y)-box 4
SPP1 secreted phosphoprotein 1
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
TCF4 transcription factor 4
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
TRIM24 tripartite motif containing 24
TSC22D3 TSC22 domain family, member 3
TUBB2B tubulin, beta 2B class IIb
VSNL1 visinin-like 1
WEE1 WEE1 G2 checkpoint kinase
ZFP36L2 ZFP36 ring finger protein-like 2