BRD-A39996500_radicicol_HCC515_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

271 genes differentially expressed following the BRD-A39996500_radicicol_HCC515_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACSM3 acyl-CoA synthetase medium-chain family member 3
ADIRF adipogenesis regulatory factor
ADRB2 adrenoceptor beta 2, surface
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ARMCX3 armadillo repeat containing, X-linked 3
ASS1 argininosuccinate synthase 1
BAG2 BCL2-associated athanogene 2
BAG3 BCL2-associated athanogene 3
BBX bobby sox homolog (Drosophila)
BEX1 brain expressed, X-linked 1
C1ORF115 chromosome 1 open reading frame 115
CA12 carbonic anhydrase XII
CARKD carbohydrate kinase domain containing
CAV1 caveolin 1, caveolae protein, 22kDa
CDKN2A cyclin-dependent kinase inhibitor 2A
CES1 carboxylesterase 1
CGA glycoprotein hormones, alpha polypeptide
CHRDL1 chordin-like 1
CKS2 CDC28 protein kinase regulatory subunit 2
CLEC3B C-type lectin domain family 3, member B
COL2A1 collagen, type II, alpha 1
COL4A5 collagen, type IV, alpha 5
COL4A6 collagen, type IV, alpha 6
CPNE3 copine III
CRABP1 cellular retinoic acid binding protein 1
CRYAB crystallin, alpha B
CTSC cathepsin C
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DHDDS dehydrodolichyl diphosphate synthase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
ELF1 E74-like factor 1 (ets domain transcription factor)
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FABP4 fatty acid binding protein 4, adipocyte
FAM117A family with sequence similarity 117, member A
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
FTH1 ferritin, heavy polypeptide 1
FXR1 fragile X mental retardation, autosomal homolog 1
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
GCLM glutamate-cysteine ligase, modifier subunit
GPC3 glypican 3
GPC4 glypican 4
GPM6B glycoprotein M6B
GPX3 glutathione peroxidase 3
GRB14 growth factor receptor-bound protein 14
GSTM2 glutathione S-transferase mu 2 (muscle)
HACD3 3-hydroxyacyl-CoA dehydratase 3
HEXIM1 hexamethylene bis-acetamide inducible 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HGD homogentisate 1,2-dioxygenase
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
ISG15 ISG15 ubiquitin-like modifier
KIAA0753 KIAA0753
KLHL24 kelch-like family member 24
KRT19 keratin 19, type I
KRT5 keratin 5, type II
LAMP2 lysosomal-associated membrane protein 2
LIMCH1 LIM and calponin homology domains 1
LPL lipoprotein lipase
MAL mal, T-cell differentiation protein
MAOA monoamine oxidase A
MAOB monoamine oxidase B
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta)
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MFAP3L microfibrillar-associated protein 3-like
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSMB microseminoprotein, beta-
MYBPC1 myosin binding protein C, slow type
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MZB1 marginal zone B and B1 cell-specific protein
NEBL nebulette
NPR3 natriuretic peptide receptor 3
NQO1 NAD(P)H dehydrogenase, quinone 1
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9
NXN nucleoredoxin
OSBPL9 oxysterol binding protein-like 9
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDLIM5 PDZ and LIM domain 5
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PIR pirin (iron-binding nuclear protein)
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2
PRELP proline/arginine-rich end leucine-rich repeat protein
PTN pleiotrophin
PTOV1 prostate tumor overexpressed 1
RBP4 retinol binding protein 4, plasma
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RBPMS RNA binding protein with multiple splicing
RGS2 regulator of G-protein signaling 2
RPS4Y1 ribosomal protein S4, Y-linked 1
RSRP1 arginine/serine-rich protein 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SCUBE2 signal peptide, CUB domain, EGF-like 2
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLPI secretory leukocyte peptidase inhibitor
SPP1 secreted phosphoprotein 1
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
STC2 stanniocalcin 2
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
THBS4 thrombospondin 4
TIMP3 TIMP metallopeptidase inhibitor 3
TNNC1 troponin C type 1 (slow)
TRIM33 tripartite motif containing 33
TTC39A tetratricopeptide repeat domain 39A
UGDH UDP-glucose 6-dehydrogenase
WASL Wiskott-Aldrich syndrome-like
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ADCY1 adenylate cyclase 1 (brain)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMIGO2 adhesion molecule with Ig-like domain 2
ARL4C ADP-ribosylation factor-like 4C
BHLHE40 basic helix-loop-helix family, member e40
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CCDC109B coiled-coil domain containing 109B
CCL2 chemokine (C-C motif) ligand 2
CCP110 centriolar coiled coil protein 110kDa
CD9 CD9 molecule
CDC25A cell division cycle 25A
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDC45 cell division cycle 45
CDCA4 cell division cycle associated 4
CDK2 cyclin-dependent kinase 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CELF2 CUGBP, Elav-like family member 2
CENPU centromere protein U
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
COL3A1 collagen, type III, alpha 1
CRIP1 cysteine-rich protein 1 (intestinal)
CXCL14 chemokine (C-X-C motif) ligand 14
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEK DEK proto-oncogene
DHFR dihydrofolate reductase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
DUT deoxyuridine triphosphatase
E2F2 E2F transcription factor 2
EDNRA endothelin receptor type A
EFHD2 EF-hand domain family, member D2
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENO2 enolase 2 (gamma, neuronal)
EPHB2 EPH receptor B2
EPS8 epidermal growth factor receptor pathway substrate 8
ETV1 ets variant 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEN1 flap structure-specific endonuclease 1
FHL1 four and a half LIM domains 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FXYD5 FXYD domain containing ion transport regulator 5
FXYD6 FXYD domain containing ion transport regulator 6
GBP1 guanylate binding protein 1, interferon-inducible
GINS2 GINS complex subunit 2 (Psf2 homolog)
GRIA2 glutamate receptor, ionotropic, AMPA 2
HES1 hes family bHLH transcription factor 1
HNMT histamine N-methyltransferase
HOPX HOP homeobox
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFI16 interferon, gamma-inducible protein 16
IFITM1 interferon induced transmembrane protein 1
IL2RB interleukin 2 receptor, beta
JAG1 jagged 1
JUN jun proto-oncogene
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
LDLR low density lipoprotein receptor
LIF leukemia inhibitory factor
LIG1 ligase I, DNA, ATP-dependent
LTF lactotransferrin
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MARCKS myristoylated alanine-rich protein kinase C substrate
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MUC1 mucin 1, cell surface associated
MYC v-myc avian myelocytomatosis viral oncogene homolog
OLFM4 olfactomedin 4
OSBPL10 oxysterol binding protein-like 10
PAQR4 progestin and adipoQ receptor family member IV
PCNA proliferating cell nuclear antigen
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PNMA2 paraneoplastic Ma antigen 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PSPH phosphoserine phosphatase
PTPRD protein tyrosine phosphatase, receptor type, D
PXMP2 peroxisomal membrane protein 2, 22kDa
RAB31 RAB31, member RAS oncogene family
RAD51 RAD51 recombinase
RECQL RecQ helicase-like
REG1A regenerating islet-derived 1 alpha
RFC4 replication factor C (activator 1) 4, 37kDa
RGS4 regulator of G-protein signaling 4
RHOBTB3 Rho-related BTB domain containing 3
RRM2 ribonucleotide reductase M2
SATB2 SATB homeobox 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC43A3 solute carrier family 43, member 3
SNAI2 snail family zinc finger 2
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
STK17A serine/threonine kinase 17a
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBI transforming growth factor, beta-induced, 68kDa
TIAM1 T-cell lymphoma invasion and metastasis 1
TK1 thymidine kinase 1, soluble
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLR4 toll-like receptor 4
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNC tenascin C
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
TPI1 triosephosphate isomerase 1
TRIB2 tribbles pseudokinase 2
TSPAN8 tetraspanin 8
TYMS thymidylate synthetase
USP1 ubiquitin specific peptidase 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VIM vimentin
WEE1 WEE1 G2 checkpoint kinase
WSB2 WD repeat and SOCS box containing 2
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
ZEB2 zinc finger E-box binding homeobox 2
ZFPM2 zinc finger protein, FOG family member 2
ZWINT ZW10 interacting kinetochore protein