BRD-A39996500_radicicol_BT20_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

291 genes differentially expressed following the BRD-A39996500_radicicol_BT20_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACSL1 acyl-CoA synthetase long-chain family member 1
ADD3 adducin 3 (gamma)
ADGRG2 adhesion G protein-coupled receptor G2
ADRB2 adrenoceptor beta 2, surface
AKAP8L A kinase (PRKA) anchor protein 8-like
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ARMCX1 armadillo repeat containing, X-linked 1
ATF5 activating transcription factor 5
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
B3GNT1
BAG3 BCL2-associated athanogene 3
BANK1 B-cell scaffold protein with ankyrin repeats 1
BEX1 brain expressed, X-linked 1
BLNK B-cell linker
BRD2 bromodomain containing 2
C1ORF54 chromosome 1 open reading frame 54
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CA12 carbonic anhydrase XII
CBR3 carbonyl reductase 3
CDK19 cyclin-dependent kinase 19
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHN1 chimerin 1
CLIC2 chloride intracellular channel 2
CLU clusterin
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL6A3 collagen, type VI, alpha 3
CPE carboxypeptidase E
CRYAB crystallin, alpha B
CST3 cystatin C
CTSL cathepsin L
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DEFB1 defensin, beta 1
DENND1B DENN/MADD domain containing 1B
DLK1 delta-like 1 homolog (Drosophila)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
EGF epidermal growth factor
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
EPCAM epithelial cell adhesion molecule
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAM162A family with sequence similarity 162, member A
FAM20B family with sequence similarity 20, member B
FASTKD5 FAST kinase domains 5
FGF13 fibroblast growth factor 13
FOLR1 folate receptor 1 (adult)
FTH1 ferritin, heavy polypeptide 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GALC galactosylceramidase
GCLC glutamate-cysteine ligase, catalytic subunit
GDF15 growth differentiation factor 15
GHITM growth hormone inducible transmembrane protein
GLUL glutamate-ammonia ligase
GOLGA7 golgin A7
GPC3 glypican 3
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GPX2 glutathione peroxidase 2
GPX3 glutathione peroxidase 3
GPX7 glutathione peroxidase 7
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IDS iduronate 2-sulfatase
IL1RN interleukin 1 receptor antagonist
JMJD6 jumonji domain containing 6
KAT6A K(lysine) acetyltransferase 6A
KDM3A lysine (K)-specific demethylase 3A
KLHDC10 kelch domain containing 10
MBP myelin basic protein
MFAP3L microfibrillar-associated protein 3-like
MME membrane metallo-endopeptidase
MXRA7 matrix-remodelling associated 7
NAP1L2 nucleosome assembly protein 1-like 2
NMT1 N-myristoyltransferase 1
NPTX2 neuronal pentraxin II
NRIP3 nuclear receptor interacting protein 3
NT5DC2 5'-nucleotidase domain containing 2
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PDZD8 PDZ domain containing 8
PER2 period circadian clock 2
PLIN2 perilipin 2
PLK1 polo-like kinase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNMAL1 paraneoplastic Ma antigen family-like 1
PPAP2B phosphatidic acid phosphatase type 2B
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTN pleiotrophin
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RYBP RING1 and YY1 binding protein
S100A8 S100 calcium binding protein A8
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SEPP1 selenoprotein P, plasma, 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SIK1 salt-inducible kinase 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLIT2 slit homolog 2 (Drosophila)
SMAD3 SMAD family member 3
SPARCL1 SPARC-like 1 (hevin)
STK17A serine/threonine kinase 17a
STK39 serine threonine kinase 39
TARP TCR gamma alternate reading frame protein
THUMPD1 THUMP domain containing 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMCO1 transmembrane and coiled-coil domains 1
TMEM45A transmembrane protein 45A
TOB1 transducer of ERBB2, 1
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TRAK2 trafficking protein, kinesin binding 2
TUFT1 tuftelin 1
TWIST1 twist family bHLH transcription factor 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UFM1 ubiquitin-fold modifier 1
UGDH UDP-glucose 6-dehydrogenase
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
VCAM1 vascular cell adhesion molecule 1
XIST X inactive specific transcript (non-protein coding)
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ACD adrenocortical dysplasia homolog (mouse)
ACOT9 acyl-CoA thioesterase 9
ACTN1 actinin, alpha 1
ADGRG1 adhesion G protein-coupled receptor G1
ADGRG6 adhesion G protein-coupled receptor G6
AEBP1 AE binding protein 1
AGR2 anterior gradient 2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMDHD2 amidohydrolase domain containing 2
ANXA3 annexin A3
AREG amphiregulin
C3 complement component 3
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CAPN1 calpain 1, (mu/I) large subunit
CD200 CD200 molecule
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD9 CD9 molecule
CDC45 cell division cycle 45
CDK4 cyclin-dependent kinase 4
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHGB chromogranin B
COL9A3 collagen, type IX, alpha 3
CTGF connective tissue growth factor
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DAAM1 dishevelled associated activator of morphogenesis 1
DHFR dihydrofolate reductase
DMD dystrophin
DPYSL3 dihydropyrimidinase-like 3
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
EGFR epidermal growth factor receptor
ETHE1 ethylmalonic encephalopathy 1
FABP4 fatty acid binding protein 4, adipocyte
FAM216A family with sequence similarity 216, member A
FHL2 four and a half LIM domains 2
FLNA filamin A, alpha
FOXF2 forkhead box F2
FXYD5 FXYD domain containing ion transport regulator 5
GADD45A growth arrest and DNA-damage-inducible, alpha
GALE UDP-galactose-4-epimerase
GATA3 GATA binding protein 3
GFOD1 glucose-fructose oxidoreductase domain containing 1
GSN gelsolin
HDAC9 histone deacetylase 9
HEG1 heart development protein with EGF-like domains 1
HMOX1 heme oxygenase 1
HN1 hematological and neurological expressed 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGFBP6 insulin-like growth factor binding protein 6
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
INHBA inhibin, beta A
ISG15 ISG15 ubiquitin-like modifier
ITGA6 integrin, alpha 6
ITGB4 integrin, beta 4
ITM2A integral membrane protein 2A
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KCTD12 potassium channel tetramerization domain containing 12
KIAA0125 KIAA0125
KRT19 keratin 19, type I
L1CAM L1 cell adhesion molecule
LGALS3 lectin, galactoside-binding, soluble, 3
LMCD1 LIM and cysteine-rich domains 1
LPL lipoprotein lipase
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MARCKSL1 MARCKS-like 1
MBNL2 muscleblind-like splicing regulator 2
MCM4 minichromosome maintenance complex component 4
MCM6 minichromosome maintenance complex component 6
MGP matrix Gla protein
MSRA methionine sulfoxide reductase A
MTUS1 microtubule associated tumor suppressor 1
MVP major vault protein
MX1 MX dynamin-like GTPase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH11 myosin, heavy chain 11, smooth muscle
MYOF myoferlin
NES nestin
NFIB nuclear factor I/B
NID1 nidogen 1
NRIP1 nuclear receptor interacting protein 1
NRN1 neuritin 1
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OAT ornithine aminotransferase
OLFML2A olfactomedin-like 2A
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PALLD palladin, cytoskeletal associated protein
PIEZO1 piezo-type mechanosensitive ion channel component 1
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLS3 plastin 3
PMEPA1 prostate transmembrane protein, androgen induced 1
PNP purine nucleoside phosphorylase
PPARG peroxisome proliferator-activated receptor gamma
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCD protein kinase C, delta
PRSS2 protease, serine, 2 (trypsin 2)
PSIP1 PC4 and SFRS1 interacting protein 1
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PSPH phosphoserine phosphatase
PTRF polymerase I and transcript release factor
RAB31 RAB31, member RAS oncogene family
RBPMS RNA binding protein with multiple splicing
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RHOB ras homolog family member B
RRAS2 related RAS viral (r-ras) oncogene homolog 2
S100A11 S100 calcium binding protein A11
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP4 secreted frizzled-related protein 4
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SNAI2 snail family zinc finger 2
SRI sorcin
SRSF1 serine/arginine-rich splicing factor 1
SVIL supervillin
TARBP1 TAR (HIV-1) RNA binding protein 1
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKTL1 transketolase-like 1
TM4SF1 transmembrane 4 L six family member 1
TOX3 TOX high mobility group box family member 3
TP53I3 tumor protein p53 inducible protein 3
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TRIM2 tripartite motif containing 2
TUBB6 tubulin, beta 6 class V
UNG uracil-DNA glycosylase
VCAN versican
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
ZEB2 zinc finger E-box binding homeobox 2
ZFPM2 zinc finger protein, FOG family member 2