BRD-A39646320_H7270_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

265 genes differentially expressed following the BRD-A39646320_H7270_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ACTG2 actin, gamma 2, smooth muscle, enteric
ALDOA aldolase A, fructose-bisphosphate
ALDOB aldolase B, fructose-bisphosphate
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18
ATF3 activating transcription factor 3
ATP10D ATPase, class V, type 10D
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1
BLNK B-cell linker
BMP2 bone morphogenetic protein 2
BTG2 BTG family, member 2
BZW2 basic leucine zipper and W2 domains 2
C14ORF132 chromosome 14 open reading frame 132
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CCDC28A coiled-coil domain containing 28A
CCND3 cyclin D3
CD163 CD163 molecule
CD24 CD24 molecule
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHGB chromogranin B
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLIC3 chloride intracellular channel 3
COL21A1 collagen, type XXI, alpha 1
CPE carboxypeptidase E
CSRP1 cysteine and glycine-rich protein 1
DDIT4 DNA-damage-inducible transcript 4
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP6 dual specificity phosphatase 6
EDN3 endothelin 3
EDNRB endothelin receptor type B
EPAS1 endothelial PAS domain protein 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GAGE3 G antigen 3
GATA6 GATA binding protein 6
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLUL glutamate-ammonia ligase
GPM6B glycoprotein M6B
GSDMB gasdermin B
GSN gelsolin
GSTA1 glutathione S-transferase alpha 1
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST1H4H histone cluster 1, H4h
HIST2H2BE histone cluster 2, H2be
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI6 interferon, alpha-inducible protein 6
IGFBP5 insulin-like growth factor binding protein 5
INA internexin neuronal intermediate filament protein, alpha
INSR insulin receptor
ISG15 ISG15 ubiquitin-like modifier
JUND jun D proto-oncogene
KLHL24 kelch-like family member 24
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MCOLN1 mucolipin 1
MT1E metallothionein 1E
MYO1D myosin ID
NCAM1 neural cell adhesion molecule 1
NCF2 neutrophil cytosolic factor 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEU1 sialidase 1 (lysosomal sialidase)
NFIL3 nuclear factor, interleukin 3 regulated
NLRP2 NLR family, pyrin domain containing 2
NPIPB3 nuclear pore complex interacting protein family, member B3
OLFM4 olfactomedin 4
PALLD palladin, cytoskeletal associated protein
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCSK1 proprotein convertase subtilisin/kexin type 1
PDLIM3 PDZ and LIM domain 3
PEG10 paternally expressed 10
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POLR1D polymerase (RNA) I polypeptide D, 16kDa
POR P450 (cytochrome) oxidoreductase
POU2AF1 POU class 2 associating factor 1
PSAP prosaposin
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAD9A RAD9 homolog A (S. pombe)
RHOB ras homolog family member B
SCPEP1 serine carboxypeptidase 1
SEPP1 selenoprotein P, plasma, 1
SERINC5 serine incorporator 5
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SQSTM1 sequestosome 1
STAT1 signal transducer and activator of transcription 1, 91kDa
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TAGLN transgelin
THEMIS2 thymocyte selection associated family member 2
TOX thymocyte selection-associated high mobility group box
TRD T cell receptor delta locus
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
WIPI1 WD repeat domain, phosphoinositide interacting 1
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ACSL5 acyl-CoA synthetase long-chain family member 5
ADI1 acireductone dioxygenase 1
AHNAK2 AHNAK nucleoprotein 2
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANXA1 annexin A1
ANXA3 annexin A3
ANXA7 annexin A7
AQP3 aquaporin 3 (Gill blood group)
ATF5 activating transcription factor 5
AURKA aurora kinase A
BASP1 brain abundant, membrane attached signal protein 1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BIN1 bridging integrator 1
BIRC5 baculoviral IAP repeat containing 5
BZW1 basic leucine zipper and W2 domains 1
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNB2 cyclin B2
CCND1 cyclin D1
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDCA3 cell division cycle associated 3
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CENPA centromere protein A
CEP55 centrosomal protein 55kDa
COL6A2 collagen, type VI, alpha 2
CTSH cathepsin H
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
DCTD dCMP deaminase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DUSP4 dual specificity phosphatase 4
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP3 epithelial membrane protein 3
EPCAM epithelial cell adhesion molecule
ESR1 estrogen receptor 1
F12 coagulation factor XII (Hageman factor)
FAM129A family with sequence similarity 129, member A
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
FSTL1 follistatin-like 1
G0S2 G0/G1 switch 2
GBE1 glucan (1,4-alpha-), branching enzyme 1
GPX1 glutathione peroxidase 1
H2AFZ H2A histone family, member Z
HMGA2 high mobility group AT-hook 2
HMGB2 high mobility group box 2
HOXA10 homeobox A10
HOXB7 homeobox B7
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IGFBP4 insulin-like growth factor binding protein 4
IGFBP6 insulin-like growth factor binding protein 6
IRAK1 interleukin-1 receptor-associated kinase 1
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KLK10 kallikrein-related peptidase 10
KPNB1 karyopherin (importin) beta 1
LAPTM4B lysosomal protein transmembrane 4 beta
LMNB1 lamin B1
LOXL1 lysyl oxidase-like 1
LTBP3 latent transforming growth factor beta binding protein 3
LY6E lymphocyte antigen 6 complex, locus E
MALL mal, T-cell differentiation protein-like
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MBNL1 muscleblind-like splicing regulator 1
MDK midkine (neurite growth-promoting factor 2)
MGST2 microsomal glutathione S-transferase 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MLPH melanophilin
MRPL23 mitochondrial ribosomal protein L23
MZT2B mitotic spindle organizing protein 2B
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NKX3-1 NK3 homeobox 1
NME1 NME/NM23 nucleoside diphosphate kinase 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NRIP1 nuclear receptor interacting protein 1
NT5E 5'-nucleotidase, ecto (CD73)
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PBK PDZ binding kinase
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PDGFC platelet derived growth factor C
PGM1 phosphoglucomutase 1
PLK1 polo-like kinase 1
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PPAP2C phosphatidic acid phosphatase type 2C
PRC1 protein regulator of cytokinesis 1
PRNP prion protein
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
RAB25 RAB25, member RAS oncogene family
RCN1 reticulocalbin 1, EF-hand calcium binding domain
S100A10 S100 calcium binding protein A10
S100A2 S100 calcium binding protein A2
SCEL sciellin
SCP2 sterol carrier protein 2
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SHCBP1 SHC SH2-domain binding protein 1
SLC35F2 solute carrier family 35, member F2
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLC43A3 solute carrier family 43, member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAGP small cell adhesion glycoprotein
SMC4 structural maintenance of chromosomes 4
SORBS3 sorbin and SH3 domain containing 3
SORD sorbitol dehydrogenase
SPDEF SAM pointed domain containing ETS transcription factor
SPINT2 serine peptidase inhibitor, Kunitz type, 2
STAG2 stromal antigen 2
STEAP1 six transmembrane epithelial antigen of the prostate 1
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
TACC3 transforming, acidic coiled-coil containing protein 3
TACSTD2 tumor-associated calcium signal transducer 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TLK1 tousled-like kinase 1
TM4SF1 transmembrane 4 L six family member 1
TMEM109 transmembrane protein 109
TMF1 TATA element modulatory factor 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TPBG trophoblast glycoprotein
TPX2 TPX2, microtubule-associated
TSPAN4 tetraspanin 4
TSPAN8 tetraspanin 8
TYMS thymidylate synthetase
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2C ubiquitin-conjugating enzyme E2C
UBE2E3 ubiquitin-conjugating enzyme E2E 3
WDR82 WD repeat domain 82
WHSC1 Wolf-Hirschhorn syndrome candidate 1
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF217 zinc finger protein 217
ZNF532 zinc finger protein 532
ZWINT ZW10 interacting kinetochore protein