BRD-A39268308_epibatidine (+/-)_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

76 genes differentially expressed following the BRD-A39268308_epibatidine (+/-)_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA2 actin, alpha 2, smooth muscle, aorta
ADAM10 ADAM metallopeptidase domain 10
AGR2 anterior gradient 2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
BCLAF1 BCL2-associated transcription factor 1
BGN biglycan
BTN3A2 butyrophilin, subfamily 3, member A2
CALD1 caldesmon 1
CD99 CD99 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CLEC11A C-type lectin domain family 11, member A
COL10A1 collagen, type X, alpha 1
COL5A2 collagen, type V, alpha 2
COMP cartilage oligomeric matrix protein
CYR61 cysteine-rich, angiogenic inducer, 61
DKK1 dickkopf WNT signaling pathway inhibitor 1
HOXC10 homeobox C10
HOXC6 homeobox C6
INHBA inhibin, beta A
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
MGP matrix Gla protein
NPR3 natriuretic peptide receptor 3
NRN1 neuritin 1
PLA2G16 phospholipase A2, group XVI
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
SORD sorbitol dehydrogenase
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRSF6 serine/arginine-rich splicing factor 6
SULF1 sulfatase 1
VCAN versican
ZNF185 zinc finger protein 185 (LIM domain)

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
AQP1 aquaporin 1 (Colton blood group)
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
CA2 carbonic anhydrase II
CD40 CD40 molecule, TNF receptor superfamily member 5
CLEC3B C-type lectin domain family 3, member B
CLIC2 chloride intracellular channel 2
CLIC5 chloride intracellular channel 5
CLU clusterin
COX5B cytochrome c oxidase subunit Vb
COX7B cytochrome c oxidase subunit VIIb
CXCL14 chemokine (C-X-C motif) ligand 14
CYCS cytochrome c, somatic
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FRZB frizzled-related protein
GRB7 growth factor receptor-bound protein 7
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IDO1 indoleamine 2,3-dioxygenase 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IL1R2 interleukin 1 receptor, type II
JCHAIN joining chain of multimeric IgA and IgM
LPAR6 lysophosphatidic acid receptor 6
MUC16 mucin 16, cell surface associated
NMU neuromedin U
PERP PERP, TP53 apoptosis effector
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PPOX protoporphyrinogen oxidase
PRCP prolylcarboxypeptidase (angiotensinase C)
PTPRO protein tyrosine phosphatase, receptor type, O
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPS5 ribosomal protein S5
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCGB2A1 secretoglobin, family 2A, member 1
SOX11 SRY (sex determining region Y)-box 11
TACSTD2 tumor-associated calcium signal transducer 2
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNNT1 troponin T type 1 (skeletal, slow)
TRIM2 tripartite motif containing 2
TSPAN7 tetraspanin 7
TUBB2A tubulin, beta 2A class IIa
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)