BRD-A38425832_NCGC00229596-01_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

165 genes differentially expressed following the BRD-A38425832_NCGC00229596-01_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG1 adhesion G protein-coupled receptor G1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ASNS asparagine synthetase (glutamine-hydrolyzing)
BEX1 brain expressed, X-linked 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLEC11A C-type lectin domain family 11, member A
COL3A1 collagen, type III, alpha 1
COL9A3 collagen, type IX, alpha 3
CTSG cathepsin G
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EFNA1 ephrin-A1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELANE elastase, neutrophil expressed
EMX2 empty spiracles homeobox 2
ENPEP glutamyl aminopeptidase (aminopeptidase A)
FADS1 fatty acid desaturase 1
FAM117A family with sequence similarity 117, member A
FOXJ3 forkhead box J3
GDF15 growth differentiation factor 15
GREB1 growth regulation by estrogen in breast cancer 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
HIP1R huntingtin interacting protein 1 related
HOXC6 homeobox C6
HSPB8 heat shock 22kDa protein 8
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
KDM4B lysine (K)-specific demethylase 4B
KDM5D lysine (K)-specific demethylase 5D
KLHL21 kelch-like family member 21
LAMP1 lysosomal-associated membrane protein 1
LAMP5 lysosomal-associated membrane protein family, member 5
LOC100505650 uncharacterized LOC100505650
MAOA monoamine oxidase A
MGP matrix Gla protein
MMP7 matrix metallopeptidase 7
MSX1 msh homeobox 1
MUC1 mucin 1, cell surface associated
MYO6 myosin VI
NPIPB3 nuclear pore complex interacting protein family, member B3
NPY1R neuropeptide Y receptor Y1
P3H2 prolyl 3-hydroxylase 2
PDZK1 PDZ domain containing 1
PDZK1IP1 PDZK1 interacting protein 1
PFKP phosphofructokinase, platelet
PRUNE2 prune homolog 2 (Drosophila)
PSAT1 phosphoserine aminotransferase 1
PTGER3 prostaglandin E receptor 3 (subtype EP3)
RAB11FIP2 RAB11 family interacting protein 2 (class I)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RPS4Y1 ribosomal protein S4, Y-linked 1
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SIAH2 siah E3 ubiquitin protein ligase 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SORBS2 sorbin and SH3 domain containing 2
SYT1 synaptotagmin I
TACSTD2 tumor-associated calcium signal transducer 2
TARP TCR gamma alternate reading frame protein
TBL1X transducin (beta)-like 1X-linked
TESC tescalcin
TGFA transforming growth factor, alpha
TLK2 tousled-like kinase 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TUBB2A tubulin, beta 2A class IIa
TXNIP thioredoxin interacting protein
YARS tyrosyl-tRNA synthetase
ZBTB20 zinc finger and BTB domain containing 20

decreased expression

Symbol Name
ARL4C ADP-ribosylation factor-like 4C
ATF1 activating transcription factor 1
C6ORF62 chromosome 6 open reading frame 62
CCL19 chemokine (C-C motif) ligand 19
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CD52 CD52 molecule
CD53 CD53 molecule
CHEK1 checkpoint kinase 1
CLEC2B C-type lectin domain family 2, member B
CLNS1A chloride channel, nucleotide-sensitive, 1A
CNN3 calponin 3, acidic
COCH cochlin
CPB1 carboxypeptidase B1 (tissue)
CYCS cytochrome c, somatic
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DLD dihydrolipoamide dehydrogenase
DPYD dihydropyrimidine dehydrogenase
DSG2 desmoglein 2
DSP desmoplakin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EIF5A eukaryotic translation initiation factor 5A
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EVI2A ecotropic viral integration site 2A
FHL1 four and a half LIM domains 1
G0S2 G0/G1 switch 2
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GMNN geminin, DNA replication inhibitor
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GOLT1B golgi transport 1B
GREM1 gremlin 1, DAN family BMP antagonist
HDGFRP3 hepatoma-derived growth factor, related protein 3
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOXD1 homeobox D1
HSBP1 heat shock factor binding protein 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IL13RA2 interleukin 13 receptor, alpha 2
INSIG1 insulin induced gene 1
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
LPXN leupaxin
LYPLA1 lysophospholipase I
MAGEA1 melanoma antigen family A1
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAN1A1 mannosidase, alpha, class 1A, member 1
MDFIC MyoD family inhibitor domain containing
MECOM MDS1 and EVI1 complex locus
MRPL15 mitochondrial ribosomal protein L15
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRIP1 nuclear receptor interacting protein 1
OXA1L oxidase (cytochrome c) assembly 1-like
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PAPD7 PAP associated domain containing 7
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBK PDZ binding kinase
PEG10 paternally expressed 10
PIP prolactin-induced protein
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLS3 plastin 3
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
PRKCI protein kinase C, iota
PRRX1 paired related homeobox 1
RECQL RecQ helicase-like
REEP5 receptor accessory protein 5
RFTN1 raftlin, lipid raft linker 1
S100A13 S100 calcium binding protein A13
SCAND1 SCAN domain containing 1
SDC2 syndecan 2
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SGK1 serum/glucocorticoid regulated kinase 1
SMC1A structural maintenance of chromosomes 1A
SNX2 sorting nexin 2
SNX7 sorting nexin 7
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit
TFPI2 tissue factor pathway inhibitor 2
TFRC transferrin receptor
TOP2A topoisomerase (DNA) II alpha 170kDa
TRPS1 trichorhinophalangeal syndrome I
TSPAN13 tetraspanin 13
UFM1 ubiquitin-fold modifier 1
WIPF1 WAS/WASL interacting protein family, member 1
ZNF331 zinc finger protein 331