BRD-A38030642_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

216 genes differentially expressed following the BRD-A38030642_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ANXA1 annexin A1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX2 armadillo repeat containing, X-linked 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BTG1 B-cell translocation gene 1, anti-proliferative
CANX calnexin
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD93 CD93 molecule
CDH5 cadherin 5, type 2 (vascular endothelium)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHGB chromogranin B
CREB3L2 cAMP responsive element binding protein 3-like 2
CTSL cathepsin L
DARS aspartyl-tRNA synthetase
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EFNA1 ephrin-A1
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERP44 endoplasmic reticulum protein 44
FABP4 fatty acid binding protein 4, adipocyte
FAM129A family with sequence similarity 129, member A
FBN2 fibrillin 2
FNDC3B fibronectin type III domain containing 3B
FST follistatin
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST2H2BE histone cluster 2, H2be
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HYOU1 hypoxia up-regulated 1
IFRD1 interferon-related developmental regulator 1
KLF6 Kruppel-like factor 6
KRT23 keratin 23, type I
LAMP3 lysosomal-associated membrane protein 3
LY96 lymphocyte antigen 96
LYZ lysozyme
MAN2A1 mannosidase, alpha, class 2A, member 1
MFAP5 microfibrillar associated protein 5
MGP matrix Gla protein
MMP7 matrix metallopeptidase 7
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
PEG3 paternally expressed 3
PHGDH phosphoglycerate dehydrogenase
PPAP2A phosphatidic acid phosphatase type 2A
RAP1GAP RAP1 GTPase activating protein
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SIK1 salt-inducible kinase 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SRGN serglycin
THBD thrombomodulin
TIMP1 TIMP metallopeptidase inhibitor 1
TNS1 tensin 1
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
VAT1 vesicle amine transport 1
VEGFA vascular endothelial growth factor A
VSIG4 V-set and immunoglobulin domain containing 4
WARS tryptophanyl-tRNA synthetase
WDR45 WD repeat domain 45
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ACOT7 acyl-CoA thioesterase 7
AKT1 v-akt murine thymoma viral oncogene homolog 1
AMDHD2 amidohydrolase domain containing 2
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CA12 carbonic anhydrase XII
CBX1 chromobox homolog 1
CCNA2 cyclin A2
CCND1 cyclin D1
CCNF cyclin F
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPM centromere protein M
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHAF1A chromatin assembly factor 1, subunit A (p150)
CHEK2 checkpoint kinase 2
DHFR dihydrofolate reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EPB41L2 erythrocyte membrane protein band 4.1-like 2
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EVL Enah/Vasp-like
EXO1 exonuclease 1
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NCAPD3 non-SMC condensin II complex, subunit D3
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NEK2 NIMA-related kinase 2
NME4 NME/NM23 nucleoside diphosphate kinase 4
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
NUP210 nucleoporin 210kDa
NUTF2 nuclear transport factor 2
OIP5 Opa interacting protein 5
ORC6 origin recognition complex, subunit 6
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PLK1 polo-like kinase 1
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PPIF peptidylprolyl isomerase F
PRC1 protein regulator of cytokinesis 1
PTTG1 pituitary tumor-transforming 1
RACGAP1 Rac GTPase activating protein 1
RAD51 RAD51 recombinase
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SEPW1 selenoprotein W, 1
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLBP stem-loop binding protein
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SNRPA1 small nuclear ribonucleoprotein polypeptide A'
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SPAG5 sperm associated antigen 5
SPC25 SPC25, NDC80 kinetochore complex component
SPDL1 spindle apparatus coiled-coil protein 1
SRSF2 serine/arginine-rich splicing factor 2
STMN1 stathmin 1
STRA13 stimulated by retinoic acid 13
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TIMELESS timeless circadian clock
TK1 thymidine kinase 1, soluble
TMEM106C transmembrane protein 106C
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TUBB tubulin, beta class I
TUBB4B tubulin, beta 4B class IVb
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UNG uracil-DNA glycosylase
VRK1 vaccinia related kinase 1
ZWINT ZW10 interacting kinetochore protein