BRD-A36630025_-666_SW620_6.0_h_0.35_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

339 genes differentially expressed following the BRD-A36630025_-666_SW620_6.0_h_0.35_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ALDOB aldolase B, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
ANKRD10 ankyrin repeat domain 10
ASPN asporin
ATF3 activating transcription factor 3
ATF5 activating transcription factor 5
ATMIN ATM interactor
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX4 brain expressed, X-linked 4
BHLHE41 basic helix-loop-helix family, member e41
BTG2 BTG family, member 2
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL5 chemokine (C-C motif) ligand 5
CCL8 chemokine (C-C motif) ligand 8
CCNE2 cyclin E2
CCR1 chemokine (C-C motif) receptor 1
CD14 CD14 molecule
CD163 CD163 molecule
CD24 CD24 molecule
CD48 CD48 molecule
CD52 CD52 molecule
CD59 CD59 molecule, complement regulatory protein
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CECR1 cat eye syndrome chromosome region, candidate 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLEC2B C-type lectin domain family 2, member B
CLGN calmegin
CPM carboxypeptidase M
CRIP1 cysteine-rich protein 1 (intestinal)
CSTA cystatin A (stefin A)
CTSV cathepsin V
CXADR coxsackie virus and adenovirus receptor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
CYCS cytochrome c, somatic
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
DEPTOR DEP domain containing MTOR-interacting protein
DLD dihydrolipoamide dehydrogenase
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSP desmoplakin
DST dystonin
DUSP1 dual specificity phosphatase 1
EGR2 early growth response 2
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
FASTKD5 FAST kinase domains 5
FBP1 fructose-1,6-bisphosphatase 1
FOXO4 forkhead box O4
FXYD2 FXYD domain containing ion transport regulator 2
FXYD3 FXYD domain containing ion transport regulator 3
GADD45B growth arrest and DNA-damage-inducible, beta
GAS1 growth arrest-specific 1
GATA2 GATA binding protein 2
GCH1 GTP cyclohydrolase 1
GIMAP6 GTPase, IMAP family member 6
GLUL glutamate-ammonia ligase
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
GSPT2 G1 to S phase transition 2
GSTM3 glutathione S-transferase mu 3 (brain)
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HEXIM1 hexamethylene bis-acetamide inducible 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGN5 high mobility group nucleosome binding domain 5
HOXA10 homeobox A10
HOXA5 homeobox A5
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
IGFBP7 insulin-like growth factor binding protein 7
ISG15 ISG15 ubiquitin-like modifier
KCTD12 potassium channel tetramerization domain containing 12
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT19 keratin 19, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAMP3 lysosomal-associated membrane protein 3
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LGALS3 lectin, galactoside-binding, soluble, 3
LUM lumican
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP9 microtubule-associated protein 9
MARCKSL1 MARCKS-like 1
MICB MHC class I polypeptide-related sequence B
MIR22HG MIR22 host gene
MMP7 matrix metallopeptidase 7
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
NDRG1 N-myc downstream regulated 1
NEU1 sialidase 1 (lysosomal sialidase)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX3-1 NK3 homeobox 1
NRBF2 nuclear receptor binding factor 2
NRIP3 nuclear receptor interacting protein 3
OAT ornithine aminotransferase
P2RY13 purinergic receptor P2Y, G-protein coupled, 13
PAEP progestagen-associated endometrial protein
PERP PERP, TP53 apoptosis effector
PGK1 phosphoglycerate kinase 1
PI3 peptidase inhibitor 3, skin-derived
PLA2G16 phospholipase A2, group XVI
PLAU plasminogen activator, urokinase
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNMAL1 paraneoplastic Ma antigen family-like 1
PPIF peptidylprolyl isomerase F
PRNP prion protein
PSAP prosaposin
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTN pleiotrophin
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RGS2 regulator of G-protein signaling 2
RP2 retinitis pigmentosa 2 (X-linked recessive)
S100A10 S100 calcium binding protein A10
S100A13 S100 calcium binding protein A13
S100A2 S100 calcium binding protein A2
S100A8 S100 calcium binding protein A8
SCGB2A2 secretoglobin, family 2A, member 2
SCPEP1 serine carboxypeptidase 1
SDC4 syndecan 4
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SLPI secretory leukocyte peptidase inhibitor
SNAI2 snail family zinc finger 2
SNX10 sorting nexin 10
SOX4 SRY (sex determining region Y)-box 4
SPATA20 spermatogenesis associated 20
STC2 stanniocalcin 2
TACSTD2 tumor-associated calcium signal transducer 2
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFPI2 tissue factor pathway inhibitor 2
TMEM45A transmembrane protein 45A
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOB1 transducer of ERBB2, 1
TP63 tumor protein p63
TREM1 triggering receptor expressed on myeloid cells 1
TRIM29 tripartite motif containing 29
VTCN1 V-set domain containing T cell activation inhibitor 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF12 zinc finger protein 12
ZNF304 zinc finger protein 304
ZNF331 zinc finger protein 331
ZNF468 zinc finger protein 468

decreased expression

Symbol Name
AARS alanyl-tRNA synthetase
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ACACA acetyl-CoA carboxylase alpha
ADAM10 ADAM metallopeptidase domain 10
ADGRG1 adhesion G protein-coupled receptor G1
AKAP13 A kinase (PRKA) anchor protein 13
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANKRD28 ankyrin repeat domain 28
ARID1A AT rich interactive domain 1A (SWI-like)
ASCC3 activating signal cointegrator 1 complex subunit 3
ASXL2 additional sex combs like transcriptional regulator 2
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BRCA1 breast cancer 1, early onset
CAB39 calcium binding protein 39
CCNB2 cyclin B2
CCNC cyclin C
CCND2 cyclin D2
CD200 CD200 molecule
CDK6 cyclin-dependent kinase 6
CEMIP cell migration inducing protein, hyaluronan binding
CENPF centromere protein F, 350/400kDa
CHD7 chromodomain helicase DNA binding protein 7
CHD9 chromodomain helicase DNA binding protein 9
COL2A1 collagen, type II, alpha 1
COL9A3 collagen, type IX, alpha 3
CREB3L2 cAMP responsive element binding protein 3-like 2
CREBBP CREB binding protein
CUL1 cullin 1
CUX1 cut-like homeobox 1
DAPK1 death-associated protein kinase 1
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DEFA5 defensin, alpha 5, Paneth cell-specific
DLC1 DLC1 Rho GTPase activating protein
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
ECD ecdysoneless homolog (Drosophila)
EPHB2 EPH receptor B2
EPS15 epidermal growth factor receptor pathway substrate 15
EPS8 epidermal growth factor receptor pathway substrate 8
ERBB2IP erbb2 interacting protein
EREG epiregulin
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FNDC3B fibronectin type III domain containing 3B
FOXJ3 forkhead box J3
FRYL FRY-like
FYN FYN proto-oncogene, Src family tyrosine kinase
GABPB1 GA binding protein transcription factor, beta subunit 1
GAREM GRB2 associated, regulator of MAPK1
GOLGA4 golgin A4
GTF2IRD1 GTF2I repeat domain containing 1
H1F0 H1 histone family, member 0
HELLS helicase, lymphoid-specific
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HOXC6 homeobox C6
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IARS isoleucyl-tRNA synthetase
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
ITGA6 integrin, alpha 6
JARID2 jumonji, AT rich interactive domain 2
KAT6A K(lysine) acetyltransferase 6A
KIAA0485 uncharacterized LOC57235
KIF14 kinesin family member 14
KLF6 Kruppel-like factor 6
LEF1 lymphoid enhancer-binding factor 1
LOC100272216 uncharacterized LOC100272216
LRP4 low density lipoprotein receptor-related protein 4
LRRC16A leucine rich repeat containing 16A
MAN2A1 mannosidase, alpha, class 2A, member 1
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MAST2 microtubule associated serine/threonine kinase 2
MBNL1 muscleblind-like splicing regulator 1
MCM3 minichromosome maintenance complex component 3
MCM6 minichromosome maintenance complex component 6
MDFIC MyoD family inhibitor domain containing
MDN1 MDN1, midasin homolog (yeast)
MED13 mediator complex subunit 13
MED13L mediator complex subunit 13-like
MELK maternal embryonic leucine zipper kinase
MGLL monoglyceride lipase
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase
MYH10 myosin, heavy chain 10, non-muscle
MYO10 myosin X
N4BP2L2 NEDD4 binding protein 2-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NF1 neurofibromin 1
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NIPBL Nipped-B homolog (Drosophila)
NOTCH2NL notch 2 N-terminal like
NPIPB3 nuclear pore complex interacting protein family, member B3
NR2F2 nuclear receptor subfamily 2, group F, member 2
NSF N-ethylmaleimide-sensitive factor
NUDCD3 NudC domain containing 3
PCM1 pericentriolar material 1
PDGFA platelet-derived growth factor alpha polypeptide
PDS5A PDS5 cohesin associated factor A
PHIP pleckstrin homology domain interacting protein
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIAS1 protein inhibitor of activated STAT, 1
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPARG peroxisome proliferator-activated receptor gamma
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRC1 protein regulator of cytokinesis 1
PROM1 prominin 1
PRRC2C proline-rich coiled-coil 2C
PRSS2 protease, serine, 2 (trypsin 2)
PSD3 pleckstrin and Sec7 domain containing 3
PSME4 proteasome (prosome, macropain) activator subunit 4
PTBP2 polypyrimidine tract binding protein 2
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PXDN peroxidasin
QKI QKI, KH domain containing, RNA binding
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RASA1 RAS p21 protein activator (GTPase activating protein) 1
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
RFTN1 raftlin, lipid raft linker 1
RGS1 regulator of G-protein signaling 1
RHOBTB3 Rho-related BTB domain containing 3
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RREB1 ras responsive element binding protein 1
SASH1 SAM and SH3 domain containing 1
SENP6 SUMO1/sentrin specific peptidase 6
SETD5 SET domain containing 5
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SPAG9 sperm associated antigen 9
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
ST7 suppression of tumorigenicity 7
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
SYT1 synaptotagmin I
TBL1X transducin (beta)-like 1X-linked
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TCF12 transcription factor 12
TCF4 transcription factor 4
TCL1A T-cell leukemia/lymphoma 1A
TFF3 trefoil factor 3 (intestinal)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMP3 TIMP metallopeptidase inhibitor 3
TLK1 tousled-like kinase 1
TMEM131 transmembrane protein 131
TMEM2 transmembrane protein 2
TMEM87A transmembrane protein 87A
TNS3 tensin 3
TOP2B topoisomerase (DNA) II beta 180kDa
TRAF5 TNF receptor-associated factor 5
TRIM33 tripartite motif containing 33
TRIP12 thyroid hormone receptor interactor 12
TSC22D2 TSC22 domain family, member 2
UBAP2 ubiquitin associated protein 2
UBE3C ubiquitin protein ligase E3C
UBR4 ubiquitin protein ligase E3 component n-recognin 4
UCK2 uridine-cytidine kinase 2
UGGT1 UDP-glucose glycoprotein glucosyltransferase 1
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
USP3 ubiquitin specific peptidase 3
USP34 ubiquitin specific peptidase 34
USP9X ubiquitin specific peptidase 9, X-linked
WNT5A wingless-type MMTV integration site family, member 5A
WSB1 WD repeat and SOCS box containing 1
ZFAND6 zinc finger, AN1-type domain 6
ZHX2 zinc fingers and homeoboxes 2
ZMIZ1 zinc finger, MIZ-type containing 1
ZMYM2 zinc finger, MYM-type 2
ZMYND8 zinc finger, MYND-type containing 8