BRD-A36630025_-666_MCF7_6.0_h_0.35_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

339 genes differentially expressed following the BRD-A36630025_-666_MCF7_6.0_h_0.35_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABHD4 abhydrolase domain containing 4
ACTA2 actin, alpha 2, smooth muscle, aorta
ADCK3 aarF domain containing kinase 3
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALDOC aldolase C, fructose-bisphosphate
ANKRD46 ankyrin repeat domain 46
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2
APMAP adipocyte plasma membrane associated protein
ARL4C ADP-ribosylation factor-like 4C
ASPN asporin
ATF3 activating transcription factor 3
BEX4 brain expressed, X-linked 4
BLCAP bladder cancer associated protein
BTG2 BTG family, member 2
C1ORF116 chromosome 1 open reading frame 116
CADM1 cell adhesion molecule 1
CCL5 chemokine (C-C motif) ligand 5
CCL8 chemokine (C-C motif) ligand 8
CCR1 chemokine (C-C motif) receptor 1
CD44 CD44 molecule (Indian blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CKB creatine kinase, brain
COL11A1 collagen, type XI, alpha 1
COL6A1 collagen, type VI, alpha 1
CSTA cystatin A (stefin A)
CXCL13 chemokine (C-X-C motif) ligand 13
DDIT4 DNA-damage-inducible transcript 4
DEGS1 delta(4)-desaturase, sphingolipid 1
DFNA5 deafness, autosomal dominant 5
DHRS1 dehydrogenase/reductase (SDR family) member 1
DMPK dystrophia myotonica-protein kinase
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DPYSL3 dihydropyrimidinase-like 3
DSP desmoplakin
EGR2 early growth response 2
EMP1 epithelial membrane protein 1
ENO2 enolase 2 (gamma, neuronal)
EPHA2 EPH receptor A2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETHE1 ethylmalonic encephalopathy 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FABP4 fatty acid binding protein 4, adipocyte
FAS Fas cell surface death receptor
FDXR ferredoxin reductase
FHOD3 formin homology 2 domain containing 3
FOSL1 FOS-like antigen 1
FUCA1 fucosidase, alpha-L- 1, tissue
FXYD3 FXYD domain containing ion transport regulator 3
GADD45A growth arrest and DNA-damage-inducible, alpha
GAS6 growth arrest-specific 6
GATA2 GATA binding protein 2
GATA6 GATA binding protein 6
GLS glutaminase
GRN granulin
GSTP1 glutathione S-transferase pi 1
HBB hemoglobin, beta
HBEGF heparin-binding EGF-like growth factor
HCAR3 hydroxycarboxylic acid receptor 3
HDAC4 histone deacetylase 4
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP5 insulin-like growth factor binding protein 5
IL1R2 interleukin 1 receptor, type II
INPP1 inositol polyphosphate-1-phosphatase
JAG1 jagged 1
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAMP3 lysosomal-associated membrane protein 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGMN legumain
LMNA lamin A/C
LY96 lymphocyte antigen 96
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAOA monoamine oxidase A
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MIR22HG MIR22 host gene
MMP12 matrix metallopeptidase 12
MMP24 matrix metallopeptidase 24 (membrane-inserted)
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
NDRG1 N-myc downstream regulated 1
NUPR1 nuclear protein, transcriptional regulator, 1
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PERP PERP, TP53 apoptosis effector
PLAU plasminogen activator, urokinase
PLD3 phospholipase D family, member 3
PLEK2 pleckstrin 2
PLK3 polo-like kinase 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNMA1 paraneoplastic Ma antigen 1
POLR1C polymerase (RNA) I polypeptide C, 30kDa
PPAP2A phosphatidic acid phosphatase type 2A
PRNP prion protein
PSAP prosaposin
PTCH1 patched 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTRF polymerase I and transcript release factor
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RALGDS ral guanine nucleotide dissociation stimulator
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RBP1 retinol binding protein 1, cellular
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
REG1A regenerating islet-derived 1 alpha
RETSAT retinol saturase (all-trans-retinol 13,14-reductase)
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
S100A2 S100 calcium binding protein A2
S100A8 S100 calcium binding protein A8
SAT1 spermidine/spermine N1-acetyltransferase 1
SCPEP1 serine carboxypeptidase 1
SDC4 syndecan 4
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SESN1 sestrin 1
SFN stratifin
SIK1 salt-inducible kinase 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SLPI secretory leukocyte peptidase inhibitor
SNAI2 snail family zinc finger 2
ST18 suppression of tumorigenicity 18, zinc finger
TIGAR TP53 induced glycolysis regulatory phosphatase
TM7SF2 transmembrane 7 superfamily member 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM45A transmembrane protein 45A
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIB2 tribbles pseudokinase 2
TRIM2 tripartite motif containing 2
TRIM22 tripartite motif containing 22
TRIM29 tripartite motif containing 29
TXNIP thioredoxin interacting protein
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
WT1 Wilms tumor 1
ZDHHC11 zinc finger, DHHC-type containing 11
ZMAT3 zinc finger, matrin-type 3
ZNF12 zinc finger protein 12
ZNF211 zinc finger protein 211
ZNF264 zinc finger protein 264

decreased expression

Symbol Name
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ADGRG6 adhesion G protein-coupled receptor G6
AGTR1 angiotensin II receptor, type 1
AKAP12 A kinase (PRKA) anchor protein 12
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ARMT1 acidic residue methyltransferase 1
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
BAMBI BMP and activin membrane-bound inhibitor
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BPTF bromodomain PHD finger transcription factor
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CA12 carbonic anhydrase XII
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CCNA2 cyclin A2
CCNB2 cyclin B2
CD58 CD58 molecule
CDC20 cell division cycle 20
CDK17 cyclin-dependent kinase 17
CENPA centromere protein A
CKS2 CDC28 protein kinase regulatory subunit 2
CNOT2 CCR4-NOT transcription complex, subunit 2
CNOT7 CCR4-NOT transcription complex, subunit 7
CP ceruloplasmin (ferroxidase)
CUX1 cut-like homeobox 1
CXCL5 chemokine (C-X-C motif) ligand 5
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
ECD ecdysoneless homolog (Drosophila)
ELF1 E74-like factor 1 (ets domain transcription factor)
ELOVL2 ELOVL fatty acid elongase 2
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ESR1 estrogen receptor 1
FAR2 fatty acyl CoA reductase 2
FNDC3B fibronectin type III domain containing 3B
FOXJ3 forkhead box J3
GABPB1 GA binding protein transcription factor, beta subunit 1
GATA3 GATA binding protein 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GPSM2 G-protein signaling modulator 2
GSPT1 G1 to S phase transition 1
GTSE1 G-2 and S-phase expressed 1
HMGB1 high mobility group box 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMMR hyaluronan-mediated motility receptor (RHAMM)
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HOXC10 homeobox C10
HOXC6 homeobox C6
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA8 heat shock 70kDa protein 8
IGF1R insulin-like growth factor 1 receptor
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
INTS3 integrator complex subunit 3
JMJD6 jumonji domain containing 6
KIAA0101 KIAA0101
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF23 kinesin family member 23
KLF6 Kruppel-like factor 6
KLHL7 kelch-like family member 7
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KPNB1 karyopherin (importin) beta 1
LARP1 La ribonucleoprotein domain family, member 1
LIMS1 LIM and senescent cell antigen-like domains 1
LPP LIM domain containing preferred translocation partner in lipoma
MAST2 microtubule associated serine/threonine kinase 2
MBNL1 muscleblind-like splicing regulator 1
MDK midkine (neurite growth-promoting factor 2)
MELK maternal embryonic leucine zipper kinase
MGLL monoglyceride lipase
MKI67 marker of proliferation Ki-67
MKL2 MKL/myocardin-like 2
MNAT1 MNAT CDK-activating kinase assembly factor 1
MSX1 msh homeobox 1
MYH10 myosin, heavy chain 10, non-muscle
MYO6 myosin VI
N4BP2L2 NEDD4 binding protein 2-like 2
NCAPG non-SMC condensin I complex, subunit G
NCAPH non-SMC condensin I complex, subunit H
NCK2 NCK adaptor protein 2
NCOA3 nuclear receptor coactivator 3
NFIB nuclear factor I/B
NIPBL Nipped-B homolog (Drosophila)
NNMT nicotinamide N-methyltransferase
NOTCH2 notch 2
NOTCH2NL notch 2 N-terminal like
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
NUP85 nucleoporin 85kDa
NUP88 nucleoporin 88kDa
NUP98 nucleoporin 98kDa
OSBPL9 oxysterol binding protein-like 9
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PAM peptidylglycine alpha-amidating monooxygenase
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBK PDZ binding kinase
PBX1 pre-B-cell leukemia homeobox 1
PCM1 pericentriolar material 1
PCSK1 proprotein convertase subtilisin/kexin type 1
PDCD6IP programmed cell death 6 interacting protein
PDLIM5 PDZ and LIM domain 5
PDS5A PDS5 cohesin associated factor A
PDS5B PDS5 cohesin associated factor B
PHACTR2 phosphatase and actin regulator 2
PKN2 protein kinase N2
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLIN2 perilipin 2
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PTK2 protein tyrosine kinase 2
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PWP1 PWP1 homolog (S. cerevisiae)
PXDN peroxidasin
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RBMX RNA binding motif protein, X-linked
RBPMS RNA binding protein with multiple splicing
RDX radixin
RPS11 ribosomal protein S11
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RREB1 ras responsive element binding protein 1
SEC14L1 SEC14-like 1 (S. cerevisiae)
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SETD5 SET domain containing 5
SFPQ splicing factor proline/glutamine-rich
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SMAD3 SMAD family member 3
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
SMC4 structural maintenance of chromosomes 4
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOS1 son of sevenless homolog 1 (Drosophila)
SPATS2L spermatogenesis associated, serine-rich 2-like
SPC25 SPC25, NDC80 kinetochore complex component
SPDEF SAM pointed domain containing ETS transcription factor
STK24 serine/threonine kinase 24
STK32B serine/threonine kinase 32B
SWAP70 SWAP switching B-cell complex 70kDa subunit
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
TAC1 tachykinin, precursor 1
TBL1X transducin (beta)-like 1X-linked
TCF4 transcription factor 4
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TIAM1 T-cell lymphoma invasion and metastasis 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM135 transmembrane protein 135
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TOP2B topoisomerase (DNA) II beta 180kDa
TPBG trophoblast glycoprotein
TPX2 TPX2, microtubule-associated
TRIM24 tripartite motif containing 24
TRIM33 tripartite motif containing 33
TRIO trio Rho guanine nucleotide exchange factor
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TTK TTK protein kinase
TUBD1 tubulin, delta 1
UBAP2 ubiquitin associated protein 2
UBE2K ubiquitin-conjugating enzyme E2K
UBE3C ubiquitin protein ligase E3C
UGCG UDP-glucose ceramide glucosyltransferase
USP34 ubiquitin specific peptidase 34
VRK2 vaccinia related kinase 2
WAPAL wings apart-like homolog (Drosophila)
XPO1 exportin 1
ZHX2 zinc fingers and homeoboxes 2
ZMYM2 zinc finger, MYM-type 2
ZMYND8 zinc finger, MYND-type containing 8
ZWILCH zwilch kinetochore protein