BRD-A36275421_MW-ras12_RMUGS_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

92 genes differentially expressed following the BRD-A36275421_MW-ras12_RMUGS_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ACP5 acid phosphatase 5, tartrate resistant
ADM adrenomedullin
ALDOA aldolase A, fructose-bisphosphate
AREG amphiregulin
ATF3 activating transcription factor 3
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CLU clusterin
COL2A1 collagen, type II, alpha 1
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP5 dual specificity phosphatase 5
E2F2 E2F transcription factor 2
ENO2 enolase 2 (gamma, neuronal)
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FGFR3 fibroblast growth factor receptor 3
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GLUL glutamate-ammonia ligase
HBEGF heparin-binding EGF-like growth factor
HK2 hexokinase 2
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
IER3 immediate early response 3
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KLF4 Kruppel-like factor 4 (gut)
KRT6A keratin 6A, type II
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MALL mal, T-cell differentiation protein-like
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MGP matrix Gla protein
MMP12 matrix metallopeptidase 12
MUC5B mucin 5B, oligomeric mucus/gel-forming
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX3-1 NK3 homeobox 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PEG3 paternally expressed 3
PENK proenkephalin
PER1 period circadian clock 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLAUR plasminogen activator, urokinase receptor
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RNMT RNA (guanine-7-) methyltransferase
RPS4Y1 ribosomal protein S4, Y-linked 1
SCRG1 stimulator of chondrogenesis 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SIK1 salt-inducible kinase 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
STC1 stanniocalcin 1
SYNJ2 synaptojanin 2
TNC tenascin C
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TXNRD1 thioredoxin reductase 1
UST uronyl-2-sulfotransferase
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
AIM1 absent in melanoma 1
C10ORF10 chromosome 10 open reading frame 10
CX3CR1 chemokine (C-X3-C motif) receptor 1
FABP4 fatty acid binding protein 4, adipocyte
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IQGAP1 IQ motif containing GTPase activating protein 1
LGALS4 lectin, galactoside-binding, soluble, 4
MECOM MDS1 and EVI1 complex locus
MEIS2 Meis homeobox 2
MRPL15 mitochondrial ribosomal protein L15
NUAK1 NUAK family, SNF1-like kinase, 1
RFTN1 raftlin, lipid raft linker 1
RIN2 Ras and Rab interactor 2
SCGB2A2 secretoglobin, family 2A, member 2
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
TSPAN12 tetraspanin 12
TUBA1A tubulin, alpha 1a
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
XIST X inactive specific transcript (non-protein coding)