BRD-A35588707_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

301 genes differentially expressed following the BRD-A35588707_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ACTA2 actin, alpha 2, smooth muscle, aorta
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA4 annexin A4
ARL14 ADP-ribosylation factor-like 14
ARL4C ADP-ribosylation factor-like 4C
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BANK1 B-cell scaffold protein with ankyrin repeats 1
BCL2L1 BCL2-like 1
BEX4 brain expressed, X-linked 4
BTG2 BTG family, member 2
C1ORF106 chromosome 1 open reading frame 106
CCDC92 coiled-coil domain containing 92
CCL5 chemokine (C-C motif) ligand 5
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CKB creatine kinase, brain
COL6A2 collagen, type VI, alpha 2
CPA3 carboxypeptidase A3 (mast cell)
CXCL13 chemokine (C-X-C motif) ligand 13
CXCR4 chemokine (C-X-C motif) receptor 4
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EPHA2 EPH receptor A2
ERBB2 erb-b2 receptor tyrosine kinase 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FBXO2 F-box protein 2
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA6 GATA binding protein 6
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GPR87 G protein-coupled receptor 87
GPX2 glutathione peroxidase 2
GSN gelsolin
GULP1 GULP, engulfment adaptor PTB domain containing 1
HIST1H2AC histone cluster 1, H2ac
HIST2H2BE histone cluster 2, H2be
HOPX HOP homeobox
IDS iduronate 2-sulfatase
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IGFBP3 insulin-like growth factor binding protein 3
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
JAG1 jagged 1
JUNB jun B proto-oncogene
KDM6A lysine (K)-specific demethylase 6A
KDM6B lysine (K)-specific demethylase 6B
KLHL24 kelch-like family member 24
LAMB3 laminin, beta 3
LGALS4 lectin, galactoside-binding, soluble, 4
MAP1B microtubule-associated protein 1B
NDRG1 N-myc downstream regulated 1
NEFL neurofilament, light polypeptide
PDGFA platelet-derived growth factor alpha polypeptide
PHLDA3 pleckstrin homology-like domain, family A, member 3
PNRC1 proline-rich nuclear receptor coactivator 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHOB ras homolog family member B
RNASET2 ribonuclease T2
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RRAGD Ras-related GTP binding D
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SESN1 sestrin 1
SLC38A2 solute carrier family 38, member 2
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SMAD3 SMAD family member 3
SPATA20 spermatogenesis associated 20
SPINT1 serine peptidase inhibitor, Kunitz type 1
SST somatostatin
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TMEM59 transmembrane protein 59
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TP53TG1 TP53 target 1 (non-protein coding)
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIM22 tripartite motif containing 22
TSC22D3 TSC22 domain family, member 3
YPEL5 yippee-like 5 (Drosophila)
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ARMT1 acidic residue methyltransferase 1
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
BARD1 BRCA1 associated RING domain 1
BCLAF1 BCL2-associated transcription factor 1
BIRC5 baculoviral IAP repeat containing 5
BLM Bloom syndrome, RecQ helicase-like
BLMH bleomycin hydrolase
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C1ORF112 chromosome 1 open reading frame 112
C3 complement component 3
CA12 carbonic anhydrase XII
CBX5 chromobox homolog 5
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CD320 CD320 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC25C cell division cycle 25C
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDKN3 cyclin-dependent kinase inhibitor 3
CDT1 chromatin licensing and DNA replication factor 1
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPM centromere protein M
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CFI complement factor I
CHEK2 checkpoint kinase 2
CIT citron rho-interacting serine/threonine kinase
CKAP5 cytoskeleton associated protein 5
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CXCL12 chemokine (C-X-C motif) ligand 12
DBF4 DBF4 zinc finger
DEPDC1 DEP domain containing 1
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
EBP emopamil binding protein (sterol isomerase)
ECT2 epithelial cell transforming 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF4B eukaryotic translation initiation factor 4B
ELOVL6 ELOVL fatty acid elongase 6
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
ESR1 estrogen receptor 1
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM64A family with sequence similarity 64, member A
FANCI Fanconi anemia, complementation group I
FBXO5 F-box protein 5
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
GABPB1 GA binding protein transcription factor, beta subunit 1
GATA3 GATA binding protein 3
GGCT gamma-glutamylcyclotransferase
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GINS3 GINS complex subunit 3 (Psf3 homolog)
GTSE1 G-2 and S-phase expressed 1
H2AFV H2A histone family, member V
H2AFZ H2A histone family, member Z
HADH hydroxyacyl-CoA dehydrogenase
HIST1H4C histone cluster 1, H4c
HJURP Holliday junction recognition protein
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HPRT1 hypoxanthine phosphoribosyltransferase 1
IFITM2 interferon induced transmembrane protein 2
IGF1R insulin-like growth factor 1 receptor
ITGB3BP integrin beta 3 binding protein (beta3-endonexin)
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18A kinesin family member 18A
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
KIF4A kinesin family member 4A
KIFC1 kinesin family member C1
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LAPTM4B lysosomal protein transmembrane 4 beta
LBR lamin B receptor
LMNB1 lamin B1
LMNB2 lamin B2
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM7 minichromosome maintenance complex component 7
MIS18A MIS18 kinetochore protein A
MKI67 marker of proliferation Ki-67
MYB v-myb avian myeloblastosis viral oncogene homolog
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NDC1 NDC1 transmembrane nucleoporin
NDC80 NDC80 kinetochore complex component
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEK2 NIMA-related kinase 2
NOTCH2 notch 2
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
NUP205 nucleoporin 205kDa
NUP210 nucleoporin 210kDa
NUP85 nucleoporin 85kDa
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase
PHGDH phosphoglycerate dehydrogenase
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PPIH peptidylprolyl isomerase H (cyclophilin H)
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PTTG1 pituitary tumor-transforming 1
RACGAP1 Rac GTPase activating protein 1
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RAD51C RAD51 paralog C
RAD54L RAD54-like (S. cerevisiae)
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RHOBTB3 Rho-related BTB domain containing 3
RNASEH2A ribonuclease H2, subunit A
RPIA ribose 5-phosphate isomerase A
RPS4Y1 ribosomal protein S4, Y-linked 1
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SCARB1 scavenger receptor class B, member 1
SDC2 syndecan 2
SEPHS1 selenophosphate synthetase 1
SEPT11 septin 11
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
SFRP1 secreted frizzled-related protein 1
SHCBP1 SHC SH2-domain binding protein 1
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SKA1 spindle and kinetochore associated complex subunit 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SPAG5 sperm associated antigen 5
SPC25 SPC25, NDC80 kinetochore complex component
SPDL1 spindle apparatus coiled-coil protein 1
SRP72 signal recognition particle 72kDa
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TDP1 tyrosyl-DNA phosphodiesterase 1
TFF3 trefoil factor 3 (intestinal)
THBS1 thrombospondin 1
TIMELESS timeless circadian clock
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TK1 thymidine kinase 1, soluble
TMEM109 transmembrane protein 109
TMEM194A transmembrane protein 194A
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPBG trophoblast glycoprotein
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TROAP trophinin associated protein
TRPS1 trichorhinophalangeal syndrome I
TTK TTK protein kinase
TUBB tubulin, beta class I
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
USP1 ubiquitin specific peptidase 1
VRK1 vaccinia related kinase 1
WFDC2 WAP four-disulfide core domain 2
WHSC1 Wolf-Hirschhorn syndrome candidate 1
ZWILCH zwilch kinetochore protein
ZWINT ZW10 interacting kinetochore protein