BRD-A34817987_itraconazole_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

133 genes differentially expressed following the BRD-A34817987_itraconazole_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTG2 actin, gamma 2, smooth muscle, enteric
AEBP1 AE binding protein 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ARG2 arginase 2
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BTG2 BTG family, member 2
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CADM1 cell adhesion molecule 1
CD24 CD24 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CFLAR CASP8 and FADD-like apoptosis regulator
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLEC2B C-type lectin domain family 2, member B
COL14A1 collagen, type XIV, alpha 1
COMP cartilage oligomeric matrix protein
CORO1A coronin, actin binding protein, 1A
CPE carboxypeptidase E
CTGF connective tissue growth factor
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DES desmin
ENOPH1 enolase-phosphatase 1
FABP4 fatty acid binding protein 4, adipocyte
FAM107A family with sequence similarity 107, member A
FBLN1 fibulin 1
FBN1 fibrillin 1
FBN2 fibrillin 2
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL1 four and a half LIM domains 1
FILIP1L filamin A interacting protein 1-like
FST follistatin
G0S2 G0/G1 switch 2
GPM6B glycoprotein M6B
HBB hemoglobin, beta
HTRA1 HtrA serine peptidase 1
IL1B interleukin 1, beta
JAM2 junctional adhesion molecule 2
KRT19 keratin 19, type I
LAMA2 laminin, alpha 2
LMO3 LIM domain only 3 (rhombotin-like 2)
LRRC17 leucine rich repeat containing 17
LRRC41 leucine rich repeat containing 41
LUM lumican
MATN2 matrilin 2
MECOM MDS1 and EVI1 complex locus
MFAP2 microfibrillar-associated protein 2
MFAP4 microfibrillar-associated protein 4
MFAP5 microfibrillar associated protein 5
MOXD1 monooxygenase, DBH-like 1
NDRG1 N-myc downstream regulated 1
NRCAM neuronal cell adhesion molecule
OGN osteoglycin
PDZD2 PDZ domain containing 2
PLN phospholamban
PODXL podocalyxin-like
PRELP proline/arginine-rich end leucine-rich repeat protein
PTN pleiotrophin
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RB1 retinoblastoma 1
RPS5 ribosomal protein S5
RTN2 reticulon 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP4 secreted frizzled-related protein 4
SGCE sarcoglycan, epsilon
SLIT2 slit homolog 2 (Drosophila)
SNAI2 snail family zinc finger 2
SNX7 sorting nexin 7
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPINK1 serine peptidase inhibitor, Kazal type 1
SRPX sushi-repeat containing protein, X-linked
SST somatostatin
STON1 stonin 1
TCF21 transcription factor 21
TGFB3 transforming growth factor, beta 3
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
THBS2 thrombospondin 2
THBS4 thrombospondin 4
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM30B transmembrane protein 30B
TMEM97 transmembrane protein 97
TPSAB1 tryptase alpha/beta 1
VAMP8 vesicle-associated membrane protein 8
ZHX2 zinc fingers and homeoboxes 2
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AMACR alpha-methylacyl-CoA racemase
ANXA1 annexin A1
ARPP19 cAMP-regulated phosphoprotein, 19kDa
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCNE2 cyclin E2
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRIP1 cysteine-rich protein 1 (intestinal)
CST3 cystatin C
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DMXL2 Dmx-like 2
EMP3 epithelial membrane protein 3
GRB14 growth factor receptor-bound protein 14
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
KIAA1598
KLF4 Kruppel-like factor 4 (gut)
KLK6 kallikrein-related peptidase 6
KYNU kynureninase
LY75 lymphocyte antigen 75
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAPK6 mitogen-activated protein kinase 6
MARCKSL1 MARCKS-like 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MUC5B mucin 5B, oligomeric mucus/gel-forming
NPDC1 neural proliferation, differentiation and control, 1
NR1H2 nuclear receptor subfamily 1, group H, member 2
PON2 paraoxonase 2
PRKCB protein kinase C, beta
RAB31 RAB31, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
SCML1 sex comb on midleg-like 1 (Drosophila)
STAT1 signal transducer and activator of transcription 1, 91kDa
TCTN1 tectonic family member 1
TGFBI transforming growth factor, beta-induced, 68kDa
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TOX3 TOX high mobility group box family member 3
TXNL4B thioredoxin-like 4B
ZBTB18 zinc finger and BTB domain containing 18
ZMYM2 zinc finger, MYM-type 2