BRD-A32595718_CVF-CSC-7 BRD-A32595718_A375_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

203 genes differentially expressed following the BRD-A32595718_CVF-CSC-7 BRD-A32595718_A375_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALB albumin
APOB apolipoprotein B
ARG2 arginase 2
AUTS2 autism susceptibility candidate 2
AZU1 azurocidin 1
BLK BLK proto-oncogene, Src family tyrosine kinase
BPHL biphenyl hydrolase-like (serine hydrolase)
CA2 carbonic anhydrase II
CALR calreticulin
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CLC Charcot-Leyden crystal galectin
COLEC12 collectin sub-family member 12
CPE carboxypeptidase E
CPQ carboxypeptidase Q
CRABP2 cellular retinoic acid binding protein 2
DCHS1 dachsous cadherin-related 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLK1 delta-like 1 homolog (Drosophila)
EPS8L1 EPS8-like 1
FBN2 fibrillin 2
FST follistatin
HIST2H2BE histone cluster 2, H2be
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-G major histocompatibility complex, class I, G
HOMER3 homer scaffolding protein 3
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IL13RA1 interleukin 13 receptor, alpha 1
IL1B interleukin 1, beta
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLF6 Kruppel-like factor 6
KLK5 kallikrein-related peptidase 5
KRT23 keratin 23, type I
MAN2A1 mannosidase, alpha, class 2A, member 1
MAOA monoamine oxidase A
MKNK1 MAP kinase interacting serine/threonine kinase 1
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
NCAM1 neural cell adhesion molecule 1
NPIPB3 nuclear pore complex interacting protein family, member B3
OBSL1 obscurin-like 1
PBX3 pre-B-cell leukemia homeobox 3
PDZK1IP1 PDZK1 interacting protein 1
PEG3 paternally expressed 3
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PRTN3 proteinase 3
PTK2B protein tyrosine kinase 2 beta
PTN pleiotrophin
RAB25 RAB25, member RAS oncogene family
RBP1 retinol binding protein 1, cellular
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SDC2 syndecan 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFRP1 secreted frizzled-related protein 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
STAR steroidogenic acute regulatory protein
SUSD4 sushi domain containing 4
TCF4 transcription factor 4
TFF3 trefoil factor 3 (intestinal)
THY1 Thy-1 cell surface antigen
TNNT1 troponin T type 1 (skeletal, slow)
TP53I3 tumor protein p53 inducible protein 3
TRIB2 tribbles pseudokinase 2
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
ACOT9 acyl-CoA thioesterase 9
ACTN1 actinin, alpha 1
ADGRG6 adhesion G protein-coupled receptor G6
ADI1 acireductone dioxygenase 1
AHR aryl hydrocarbon receptor
AKR1C3 aldo-keto reductase family 1, member C3
ALCAM activated leukocyte cell adhesion molecule
AMD1 adenosylmethionine decarboxylase 1
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
APOD apolipoprotein D
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATF1 activating transcription factor 1
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
BAG3 BCL2-associated athanogene 3
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C6ORF62 chromosome 6 open reading frame 62
C8ORF4 chromosome 8 open reading frame 4
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2
CD47 CD47 molecule
CDH19 cadherin 19, type 2
CDK4 cyclin-dependent kinase 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CENPA centromere protein A
CHMP4A charged multivesicular body protein 4A
CHSY1 chondroitin sulfate synthase 1
CLIC4 chloride intracellular channel 4
CORO1C coronin, actin binding protein, 1C
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSRP1 cysteine and glycine-rich protein 1
CTGF connective tissue growth factor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL9 chemokine (C-X-C motif) ligand 9
DCK deoxycytidine kinase
DCN decorin
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DLD dihydrolipoamide dehydrogenase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DYNLT3 dynein, light chain, Tctex-type 3
EBNA1BP2 EBNA1 binding protein 2
EPB41L2 erythrocyte membrane protein band 4.1-like 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ETNK1 ethanolamine kinase 1
FASTKD5 FAST kinase domains 5
FXYD2 FXYD domain containing ion transport regulator 2
GOLPH3 golgi phosphoprotein 3 (coat-protein)
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRSF1 G-rich RNA sequence binding factor 1
GSPT2 G1 to S phase transition 2
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA1A heat shock 70kDa protein 1A
HSPB11 heat shock protein family B (small), member 11
HSPH1 heat shock 105kDa/110kDa protein 1
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IL13RA2 interleukin 13 receptor, alpha 2
IL18 interleukin 18
ITGB5 integrin, beta 5
KIF14 kinesin family member 14
KIF2C kinesin family member 2C
KRT14 keratin 14, type I
KYNU kynureninase
LACTB2 lactamase, beta 2
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LUM lumican
LXN latexin
MAP7 microtubule-associated protein 7
MBNL2 muscleblind-like splicing regulator 2
MET MET proto-oncogene, receptor tyrosine kinase
MORC4 MORC family CW-type zinc finger 4
MPZL1 myelin protein zero-like 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYO6 myosin VI
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NFIB nuclear factor I/B
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
OAT ornithine aminotransferase
OLFM4 olfactomedin 4
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PHF20 PHD finger protein 20
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLS3 plastin 3
PNMAL1 paraneoplastic Ma antigen family-like 1
PPA1 pyrophosphatase (inorganic) 1
PRPF4 pre-mRNA processing factor 4
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTP4A1 protein tyrosine phosphatase type IVA, member 1
QDPR quinoid dihydropteridine reductase
RABGAP1 RAB GTPase activating protein 1
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RFK riboflavin kinase
RPP25 ribonuclease P/MRP 25kDa subunit
RPS11 ribosomal protein S11
SACS sacsin molecular chaperone
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC31A1 solute carrier family 31 (copper transporter), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SMS spermine synthase
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SNX10 sorting nexin 10
SOAT1 sterol O-acyltransferase 1
SRGN serglycin
STAT1 signal transducer and activator of transcription 1, 91kDa
STOM stomatin
TFAM transcription factor A, mitochondrial
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
TM4SF1 transmembrane 4 L six family member 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TPD52L1 tumor protein D52-like 1
TSC22D1 TSC22 domain family, member 1
TSNAX translin-associated factor X
TSPAN13 tetraspanin 13
TSPAN4 tetraspanin 4
TXNDC9 thioredoxin domain containing 9
USP1 ubiquitin specific peptidase 1
XPO1 exportin 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon