BRD-A30437061_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

224 genes differentially expressed following the BRD-A30437061_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ADD3 adducin 3 (gamma)
ADM adrenomedullin
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANOS1 anosmin 1
ANXA4 annexin A4
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
AUTS2 autism susceptibility candidate 2
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BEX4 brain expressed, X-linked 4
C4BPA complement component 4 binding protein, alpha
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CALML3 calmodulin-like 3
CAST calpastatin
CD44 CD44 molecule (Indian blood group)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKB creatine kinase, brain
CLC Charcot-Leyden crystal galectin
CLEC2B C-type lectin domain family 2, member B
CLNS1A chloride channel, nucleotide-sensitive, 1A
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL6A1 collagen, type VI, alpha 1
CPA3 carboxypeptidase A3 (mast cell)
CSTA cystatin A (stefin A)
CXADR coxsackie virus and adenovirus receptor
CYB5A cytochrome b5 type A (microsomal)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYSL3 dihydropyrimidinase-like 3
DSP desmoplakin
EGFR epidermal growth factor receptor
EMP1 epithelial membrane protein 1
ENO2 enolase 2 (gamma, neuronal)
EPAS1 endothelial PAS domain protein 1
EXPH5 exophilin 5
FBLN1 fibulin 1
FGFR3 fibroblast growth factor receptor 3
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXF1 forkhead box F1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GJA1 gap junction protein, alpha 1, 43kDa
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
GSTA4 glutathione S-transferase alpha 4
HCAR3 hydroxycarboxylic acid receptor 3
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFITM1 interferon induced transmembrane protein 1
IFITM3 interferon induced transmembrane protein 3
IGFBP7 insulin-like growth factor binding protein 7
INA internexin neuronal intermediate filament protein, alpha
INSM1 insulinoma-associated 1
JAG1 jagged 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KRT13 keratin 13, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
LAMP3 lysosomal-associated membrane protein 3
LAPTM4B lysosomal protein transmembrane 4 beta
LUM lumican
MAOA monoamine oxidase A
MEIS2 Meis homeobox 2
NDRG1 N-myc downstream regulated 1
NELL2 NEL-like 2 (chicken)
OLFM4 olfactomedin 4
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PDE4DIP phosphodiesterase 4D interacting protein
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RNF167 ring finger protein 167
S100A2 S100 calcium binding protein A2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCG2 secretogranin II
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCGB2A1 secretoglobin, family 2A, member 1
SDC2 syndecan 2
SEPP1 selenoprotein P, plasma, 1
SEPT10 septin 10
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFN stratifin
SFTPA2 surfactant protein A2
SFTPC surfactant protein C
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SPINK5 serine peptidase inhibitor, Kazal type 5
SST somatostatin
STC1 stanniocalcin 1
TMEM45A transmembrane protein 45A
TMSB15A thymosin beta 15a
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRDV3 T cell receptor delta variable 3
TTC3 tetratricopeptide repeat domain 3
UBE3B ubiquitin protein ligase E3B
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VTCN1 V-set domain containing T cell activation inhibitor 1
WNT5A wingless-type MMTV integration site family, member 5A
XCL1 chemokine (C motif) ligand 1
ZDHHC11 zinc finger, DHHC-type containing 11

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ACBD3 acyl-CoA binding domain containing 3
AGR2 anterior gradient 2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALG5 ALG5, dolichyl-phosphate beta-glucosyltransferase
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAG3 BCL2-associated athanogene 3
BASP1 brain abundant, membrane attached signal protein 1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
C2CD2 C2 calcium-dependent domain containing 2
C9ORF3 chromosome 9 open reading frame 3
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
COIL coilin
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CXCL12 chemokine (C-X-C motif) ligand 12
DHRS2 dehydrogenase/reductase (SDR family) member 2
E2F3 E2F transcription factor 3
EIF4B eukaryotic translation initiation factor 4B
ELF1 E74-like factor 1 (ets domain transcription factor)
ELOVL2 ELOVL fatty acid elongase 2
ERBB2 erb-b2 receptor tyrosine kinase 2
ESR1 estrogen receptor 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM111A family with sequence similarity 111, member A
FOXJ3 forkhead box J3
GABPB1 GA binding protein transcription factor, beta subunit 1
GATA3 GATA binding protein 3
GCH1 GTP cyclohydrolase 1
GOLGA8A golgin A8 family, member A
GREB1 growth regulation by estrogen in breast cancer 1
GRWD1 glutamate-rich WD repeat containing 1
GSPT1 G1 to S phase transition 1
GTPBP4 GTP binding protein 4
HN1 hematological and neurological expressed 1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HOXC6 homeobox C6
ICT1 immature colon carcinoma transcript 1
IGF1R insulin-like growth factor 1 receptor
IGFBP4 insulin-like growth factor binding protein 4
JMJD6 jumonji domain containing 6
KIAA1033 KIAA1033
KIF14 kinesin family member 14
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KYNU kynureninase
LUC7L3 LUC7-like 3 (S. cerevisiae)
MCM10 minichromosome maintenance complex component 10
MED13 mediator complex subunit 13
MGP matrix Gla protein
N4BP2L2 NEDD4 binding protein 2-like 2
NET1 neuroepithelial cell transforming 1
NFIB nuclear factor I/B
NNMT nicotinamide N-methyltransferase
NOL11 nucleolar protein 11
NOTCH2 notch 2
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
NUP85 nucleoporin 85kDa
NUPL1 nucleoporin like 1
OSR2 odd-skipped related transciption factor 2
PARP2 poly (ADP-ribose) polymerase 2
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PCDH9 protocadherin 9
PDS5B PDS5 cohesin associated factor B
PFKP phosphofructokinase, platelet
PLK1 polo-like kinase 1
PNN pinin, desmosome associated protein
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PSMG2 proteasome (prosome, macropain) assembly chaperone 2
PSPC1 paraspeckle component 1
RAD51C RAD51 paralog C
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
RFC3 replication factor C (activator 1) 3, 38kDa
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RNF6 ring finger protein (C3H2C3 type) 6
RPL36AL ribosomal protein L36a-like
RPS26 ribosomal protein S26
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUVBL1 RuvB-like AAA ATPase 1
SACS sacsin molecular chaperone
SAP30BP SAP30 binding protein
SFRP4 secreted frizzled-related protein 4
SIAH2 siah E3 ubiquitin protein ligase 2
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SPDEF SAM pointed domain containing ETS transcription factor
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TBP TATA box binding protein
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TEX10 testis expressed 10
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TRIM37 tripartite motif containing 37
TSC22D2 TSC22 domain family, member 2
TUBD1 tubulin, delta 1
USP22 ubiquitin specific peptidase 22
USP3 ubiquitin specific peptidase 3
XBP1 X-box binding protein 1
ZMYM2 zinc finger, MYM-type 2