BRD-A30395175_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

103 genes differentially expressed following the BRD-A30395175_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADCK3 aarF domain containing kinase 3
ANKRD10 ankyrin repeat domain 10
ATHL1 ATH1, acid trehalase-like 1 (yeast)
CD59 CD59 molecule, complement regulatory protein
CHL1 cell adhesion molecule L1-like
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
ECI2 enoyl-CoA delta isomerase 2
EML3 echinoderm microtubule associated protein like 3
FAM46A family with sequence similarity 46, member A
FOLR1 folate receptor 1 (adult)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOPX HOP homeobox
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KIAA0125 KIAA0125
KLK11 kallikrein-related peptidase 11
KRT1 keratin 1, type II
LMO4 LIM domain only 4
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MMP7 matrix metallopeptidase 7
NT5DC2 5'-nucleotidase domain containing 2
PEBP1 phosphatidylethanolamine binding protein 1
RCAN1 regulator of calcineurin 1
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGS2 regulator of G-protein signaling 2
RUNX3 runt-related transcription factor 3
SESN1 sestrin 1
SFN stratifin
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SORD sorbitol dehydrogenase
SPRR2B small proline-rich protein 2B
TFF3 trefoil factor 3 (intestinal)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TSPAN13 tetraspanin 13
UBE2E1 ubiquitin-conjugating enzyme E2E 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGCG UDP-glucose ceramide glucosyltransferase

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ADM adrenomedullin
ANPEP alanyl (membrane) aminopeptidase
ARL4C ADP-ribosylation factor-like 4C
ASPN asporin
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2
CAV1 caveolin 1, caveolae protein, 22kDa
CD40 CD40 molecule, TNF receptor superfamily member 5
CD44 CD44 molecule (Indian blood group)
CD93 CD93 molecule
CES1 carboxylesterase 1
COL11A1 collagen, type XI, alpha 1
CXCL9 chemokine (C-X-C motif) ligand 9
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DHRS3 dehydrogenase/reductase (SDR family) member 3
EIF5 eukaryotic translation initiation factor 5
EPAS1 endothelial PAS domain protein 1
EREG epiregulin
FAM69A family with sequence similarity 69, member A
FBXL12 F-box and leucine-rich repeat protein 12
FGFR2 fibroblast growth factor receptor 2
FILIP1L filamin A interacting protein 1-like
GBP1 guanylate binding protein 1, interferon-inducible
GNAS GNAS complex locus
GSTA1 glutathione S-transferase alpha 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP7 insulin-like growth factor binding protein 7
IGL immunoglobulin lambda locus
IPO13 importin 13
JAG1 jagged 1
MFAP5 microfibrillar associated protein 5
MN1 meningioma (disrupted in balanced translocation) 1
MXRA5 matrix-remodelling associated 5
MYO1B myosin IB
NID1 nidogen 1
NT5E 5'-nucleotidase, ecto (CD73)
PLN phospholamban
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
RTN1 reticulon 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SHB Src homology 2 domain containing adaptor protein B
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SNAI2 snail family zinc finger 2
SNX13 sorting nexin 13
SOX11 SRY (sex determining region Y)-box 11
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SULF1 sulfatase 1
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM204 transmembrane protein 204
TMSB15A thymosin beta 15a
TRIM2 tripartite motif containing 2
ZNF395 zinc finger protein 395