BRD-A29082194_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

164 genes differentially expressed following the BRD-A29082194_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AKAP8L A kinase (PRKA) anchor protein 8-like
AKIRIN1 akirin 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANKRD10 ankyrin repeat domain 10
ANXA3 annexin A3
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AREG amphiregulin
ASS1 argininosuccinate synthase 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BRD4 bromodomain containing 4
BTG3 BTG family, member 3
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CKS1B CDC28 protein kinase regulatory subunit 1B
CPM carboxypeptidase M
CREB3L2 cAMP responsive element binding protein 3-like 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTGF connective tissue growth factor
CTSV cathepsin V
CWH43 cell wall biogenesis 43 C-terminal homolog (S. cerevisiae)
CXADR coxsackie virus and adenovirus receptor
CYBA cytochrome b-245, alpha polypeptide
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DNMBP dynamin binding protein
DUSP4 dual specificity phosphatase 4
EDN3 endothelin 3
EFNA1 ephrin-A1
EPCAM epithelial cell adhesion molecule
EPHA4 EPH receptor A4
EZR ezrin
FAIM Fas apoptotic inhibitory molecule
FAM46A family with sequence similarity 46, member A
FASN fatty acid synthase
FBXL12 F-box and leucine-rich repeat protein 12
FGFBP1 fibroblast growth factor binding protein 1
FHL1 four and a half LIM domains 1
GAL galanin/GMAP prepropeptide
GALC galactosylceramidase
GATA6 GATA binding protein 6
GPATCH8 G patch domain containing 8
GPRC5A G protein-coupled receptor, class C, group 5, member A
H1FX H1 histone family, member X
HDAC9 histone deacetylase 9
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2BG histone cluster 1, H2bg
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGHM immunoglobulin heavy constant mu
INSIG1 insulin induced gene 1
INSR insulin receptor
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA8 integrin, alpha 8
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
KLK5 kallikrein-related peptidase 5
KRT19 keratin 19, type I
KRT6B keratin 6B, type II
LTF lactotransferrin
MACF1 microtubule-actin crosslinking factor 1
MALL mal, T-cell differentiation protein-like
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP7 microtubule-associated protein 7
MT1E metallothionein 1E
MT1G metallothionein 1G
MYO6 myosin VI
NR2F2 nuclear receptor subfamily 2, group F, member 2
NT5E 5'-nucleotidase, ecto (CD73)
NUPL1 nucleoporin like 1
NXN nucleoredoxin
OSBPL10 oxysterol binding protein-like 10
PALLD palladin, cytoskeletal associated protein
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PRDX2 peroxiredoxin 2
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBP1 retinol binding protein 1, cellular
RERE arginine-glutamic acid dipeptide (RE) repeats
RGCC regulator of cell cycle
SC5D sterol-C5-desaturase
SDC2 syndecan 2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFRP1 secreted frizzled-related protein 1
SGPP1 sphingosine-1-phosphate phosphatase 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SNX13 sorting nexin 13
SOSTDC1 sclerostin domain containing 1
SOX4 SRY (sex determining region Y)-box 4
SPTBN1 spectrin, beta, non-erythrocytic 1
SSFA2 sperm specific antigen 2
STC1 stanniocalcin 1
STOM stomatin
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TSKU tsukushi, small leucine rich proteoglycan
TXNIP thioredoxin interacting protein
WEE1 WEE1 G2 checkpoint kinase
WISP2 WNT1 inducible signaling pathway protein 2
YAP1 Yes-associated protein 1

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA4 annexin A4
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
B3GNT1
CBR3 carbonyl reductase 3
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CSTA cystatin A (stefin A)
CTSH cathepsin H
DACH1 dachshund family transcription factor 1
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DPYSL2 dihydropyrimidinase-like 2
EFCAB14 EF-hand calcium binding domain 14
EIF5A eukaryotic translation initiation factor 5A
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
F12 coagulation factor XII (Hageman factor)
F13A1 coagulation factor XIII, A1 polypeptide
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GPRC5B G protein-coupled receptor, class C, group 5, member B
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
INTS3 integrator complex subunit 3
LGALS3 lectin, galactoside-binding, soluble, 3
MAPT microtubule-associated protein tau
MAT2A methionine adenosyltransferase II, alpha
MKNK1 MAP kinase interacting serine/threonine kinase 1
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NMRK1 nicotinamide riboside kinase 1
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NREP neuronal regeneration related protein
PCYOX1L prenylcysteine oxidase 1 like
PLAC8 placenta-specific 8
PLAT plasminogen activator, tissue
PLK2 polo-like kinase 2
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RPP40 ribonuclease P/MRP 40kDa subunit
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A2 S100 calcium binding protein A2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRGN serglycin
TBC1D31 TBC1 domain family, member 31
TCEA2 transcription elongation factor A (SII), 2
THYN1 thymocyte nuclear protein 1
TLR4 toll-like receptor 4
TMEM176B transmembrane protein 176B
TRIM14 tripartite motif containing 14
TSEN2 TSEN2 tRNA splicing endonuclease subunit
ZNF302 zinc finger protein 302